[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100625675":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":30,"centralContacts":44,"locations":52,"responsibleParty":105,"collaborators":25,"id":108,"slug":109,"hasResults":110,"nctId":111,"briefTitle":112,"officialTitle":113,"acronym":25,"eligibilityCriteria":114,"healthyVolunteers":110,"sex":115,"minAge":116,"maxAge":117,"enrollmentInfo":118,"targetDuration":25,"studyType":121,"phases":122,"briefSummary":124,"conditions":125,"keywords":25,"overallStatus":128,"whyStopped":25,"lastUpdateSubmitDate":129,"lastUpdatePostDateStruct":130,"startDateStruct":133,"completionDateStruct":135,"leadSponsor":137,"locationsCount":138},{"fullName":5,"class":6},"Shanghai High Myopia Study Group","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"TMS","EXPERIMENTAL","The TMS group will receive theta burst stimulation targeting bilateral occipital visual cortex, with five consecutive daily sessions.",[13],"Procedure: Transcranial magnetic stimulation targeting occipital visual cortex",{"label":15,"type":16,"description":17,"interventionNames":18},"Control","SHAM_COMPARATOR","The control group will undergo identical procedures using a sham coil without effective magnetic field output.",[19],"Procedure: Sham stimulation",[21,26],{"type":22,"name":23,"description":23,"armGroupLabels":24,"otherNames":25},"PROCEDURE","Transcranial magnetic stimulation targeting occipital visual cortex",[9],null,{"type":22,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Sham stimulation","identical procedure using a sham coil without effective magnetic field output",[15],[31,35,38,41],{"name":32,"affiliation":33,"role":34},"Xiangjia Zhu, PhD, MD","Eye and Ear, Nose, Throat Hospital of Fudan University","PRINCIPAL_INVESTIGATOR",{"name":36,"affiliation":37,"role":34},"Mingguang He","The Hong Kong Polytechnic University",{"name":39,"affiliation":40,"role":34},"Rong Wu","Huadong Hospital of Fudan University",{"name":42,"affiliation":43,"role":34},"Bo Ma","Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University",[45,49],{"name":32,"role":46,"phone":47,"phoneExt":25,"email":48},"CONTACT","+0086-02164377134","zhuxiangjia1982@126.com",{"name":50,"role":46,"phone":25,"phoneExt":25,"email":51},"Jiaqi Meng, MD","jqmeng22@163.com",[53,69,84,94],{"facility":54,"status":25,"city":55,"state":25,"zip":25,"country":56,"countryCode":57,"cosmosGeoPoint":58,"geoPoint":63,"contacts":64},"Hong Kong Polytechnic University","Hong Kong","China","CN",{"type":59,"coordinates":60},"Point",[61,62],114.17469,22.27832,{"lat":62,"lon":61},[65,67],{"name":50,"role":46,"phone":66,"phoneExt":25,"email":51},"+0086-15221915385",{"name":68,"role":34,"phone":25,"phoneExt":25,"email":25},"Mingguang He, PhD",{"facility":33,"status":25,"city":70,"state":25,"zip":71,"country":56,"countryCode":57,"cosmosGeoPoint":72,"geoPoint":76,"contacts":77},"Shanghai","200031",{"type":59,"coordinates":73},[74,75],121.45806,31.22222,{"lat":75,"lon":74},[78,79,81,82],{"name":50,"role":46,"phone":47,"phoneExt":25,"email":51},{"name":50,"role":80,"phone":25,"phoneExt":25,"email":25},"SUB_INVESTIGATOR",{"name":32,"role":34,"phone":25,"phoneExt":25,"email":25},{"name":83,"role":80,"phone":25,"phoneExt":25,"email":25},"Wenwen He, MD",{"facility":40,"status":25,"city":70,"state":25,"zip":25,"country":56,"countryCode":57,"cosmosGeoPoint":85,"geoPoint":87,"contacts":88},{"type":59,"coordinates":86},[74,75],{"lat":75,"lon":74},[89,93],{"name":90,"role":46,"phone":91,"phoneExt":25,"email":92},"Rong Wu, MD","+0086-13636624399","alicewen@139.com",{"name":90,"role":34,"phone":25,"phoneExt":25,"email":25},{"facility":95,"status":25,"city":70,"state":25,"zip":25,"country":56,"countryCode":57,"cosmosGeoPoint":96,"geoPoint":98,"contacts":99},"Shanghai Ninth People's Hospital",{"type":59,"coordinates":97},[74,75],{"lat":75,"lon":74},[100,104],{"name":101,"role":46,"phone":102,"phoneExt":25,"email":103},"Bo Ma, MD","+0086-13701749192","boma1983@hotmail.com",{"name":101,"role":34,"phone":25,"phoneExt":25,"email":25},{"type":34,"investigatorFullName":106,"investigatorTitle":107,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"Xiangjia Zhu","PhD, MD","100625675","multicenter-study-of-transcranial-magnetic-stimulation-on-vision-restoration-100625675",false,"NCT07425717","Multicenter Study of Transcranial Magnetic Stimulation on Vision Restoration","Effectiveness of TMS for Visual Restoration: a Multicenter Randomized Controlled Trial","Inclusion Criteria:\n\n* between 45 and 70 years old\n* bilateral severe MMD (META-PM grades ≥ 3)\n* no prior TMS history or contraindications to TMS\n\nExclusion Criteria:\n\n* other significant ocular diseases, such as refractive media opacity, glaucoma, uveitis, ocular trauma, untreated retinal detachment, or lens dislocation\n* received anti-vascular endothelial growth factor treatment or other ocular surgeries within 3 months\n* history of epilepsy or family history of epilepsy, intracranial metal implants, or severe cerebrovascular diseases\n* mental illness, cognitive impairment (MMSE score \\\u003C 24), unable to communicate effectively\n* severe heart disease, liver or kidney dysfunction, or coagulation disorders\n* pregnant or lactating women\n* currently participating in other clinical trials.","ALL","45 Years","70 Years",{"count":119,"type":120},136,"ESTIMATED","INTERVENTIONAL",[123],"NA","The goal of this clinical trial is to learn if transcranial magnetic stimulation (TMS) works to restore vision in adults with severe retinal degeneration. It will also learn about the safety of TMS treatment. The main questions it aims to answer are:\n\n1. Does TMS treatment improve the visual function of participants?\n2. What medical problems do participants have when receiving TMS treatment? Researchers will compare TMS treatment to a sham stimulation (identical procedures using a sham coil without effective magnetic field output) to see if TMS treatment works to restore their vision.\n\nParticipants will:\n\nUndergoTMS treatment to a sham stimulation for consecutive 5 days Visit the clinic at 5 days, 4 weeks, 3 months, 6 months, 12 months after start of the treatment for checkups and tests",[126,127],"Retinal Degeneration","Vision Impairment and Blindness","NOT_YET_RECRUITING","2026-02-20",{"date":131,"type":132},"2026-02-23","ACTUAL",{"date":134,"type":120},"2026-06-01",{"date":136,"type":120},"2029-05-31",{"name":5,"class":6},4]