[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100555061":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":24,"centralContacts":28,"locations":37,"responsibleParty":68,"collaborators":70,"id":74,"slug":75,"hasResults":76,"nctId":77,"briefTitle":78,"officialTitle":79,"acronym":80,"eligibilityCriteria":81,"healthyVolunteers":82,"sex":83,"minAge":84,"maxAge":23,"enrollmentInfo":85,"targetDuration":23,"studyType":88,"phases":89,"briefSummary":91,"conditions":92,"keywords":23,"overallStatus":39,"whyStopped":23,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":104},{"fullName":5,"class":6},"Florida Institute for Human and Machine Cognition","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Phase I (12 weeks)","EXPERIMENTAL","In Interrogation, all participants will exercise train using an exercise prescription that is in accordance with current public health recommendations. At the end of Phase I participants will be classified into one of four categories: (1) CRF-\u002FfMQ-, 2) CRF-\u002FfMQ+, 3) CRF+\u002FfMQ- and 4) CRF+\u002FfMQ+).",[13],"Other: Combined endurance and resistance training",{"label":15,"type":10,"description":16,"interventionNames":17},"Phase II (10 weeks)","Based on the Phase I categories of responsiveness, exercise training will be boosted in the three groups that are non-responsive in one or both outcomes. CRF-\u002FfMQ+ will receive boosted ET, CRF+\u002FfMQ- will receive boosted RT, and CRF-\u002FfMQ- will receive boosting in both. All three of these classifications will also receive education on wearable device data and other free-living recommendations. Participants classified as CRF+\u002FfMQ+ at the end of Phase I will be randomized to either continue the supervised exercise training or to free-living.",[13],[19],{"type":6,"name":20,"description":21,"armGroupLabels":22,"otherNames":23},"Combined endurance and resistance training","ET will consist of 3x\u002Fwk training (MWF) with MF being steady state cycling, treadmill, or elliptical at 70-75% HRR for 30 min and the W session being a 20 min high intensity interval session on a cycle ergometer (1 min on\u002Foff; 10 cycles) targeting 85-90% HRR. The treadmill and elliptical on M or F will be provided for variety but the mainstay will be cycle ergometry. On MF participants will complete 3 sets x 8-12 repetitions for leg press, knee extension, hamstring curl, chest press, seated row, overhead press, lat pulldown, triceps push-down, and biceps curl in superset fashion \\[i.e., alternate between opposing muscle groups without rest (chest press followed by seated row)\\] with a 60 s rest between supersets. Sets will be performed with load progression to ensure volitional fatigue in the 8-12 rep range. Core exercises (trunk flexion and extension) will also be included using bodyweight only for 3 sets.",[9,15],null,[25],{"name":26,"affiliation":5,"role":27},"Marcas Bamman","PRINCIPAL_INVESTIGATOR",[29,34],{"name":30,"role":31,"phone":32,"phoneExt":23,"email":33},"Craig Tuggle","CONTACT","205-352-6036","ctuggle@ihmc.org",{"name":35,"role":31,"phone":23,"phoneExt":23,"email":36},"Marcas Bamman, PHD","mbamman@ihmc.org",[38,53],{"facility":5,"status":39,"city":40,"state":41,"zip":42,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"RECRUITING","Pensacola","Florida","32502","United States","US",{"type":46,"coordinates":47},"Point",[48,49],-87.21691,30.42131,{"lat":49,"lon":48},[52],{"name":30,"role":31,"phone":32,"phoneExt":23,"email":33},{"facility":54,"status":39,"city":55,"state":56,"zip":57,"country":43,"countryCode":44,"cosmosGeoPoint":58,"geoPoint":62,"contacts":63},"Oklahoma Medical Research Foundation","Oklahoma City","Oklahoma","73104",{"type":46,"coordinates":59},[60,61],-97.51643,35.46756,{"lat":61,"lon":60},[64],{"name":65,"role":31,"phone":66,"phoneExt":23,"email":67},"Ben Miller, PHD","405-271-7767","Benjamin-Miller@omrf.org",{"type":69,"investigatorFullName":23,"investigatorTitle":23,"investigatorAffiliation":23,"oldNameTitle":23,"oldOrganization":23},"SPONSOR",[71,73],{"name":72,"class":6},"University of Florida",{"name":54,"class":6},"100555061","multidimensional-predictive-modeling-to-understand-mechanisms-of-exercise-response-heterogeneity-in-older-adults-m3ax-100555061",false,"NCT06507189","Multidimensional Predictive Modeling to Understand Mechanisms of Exercise Response Heterogeneity in Older Adults (M3AX)","Multidimensional Predictive Modeling to Understand Mechanisms of Exercise Response Heterogeneity in Older Adults","M3AX","Inclusion Criteria:\n\n1. Male or female aged 60 or above\n2. Free of chronic disease\n3. No structured exercise program (2 or more bouts\u002Fwk) within previous 12 months\n4. Cognitively capable of providing informed consent\n\nExclusion Criteria:\n\n1. Neuromuscular or musculoskeletal disorder that would limit ability to perform the exercise and\u002For testing bouts\n2. Cardiopulmonary disorders or reduced breathing capacity\n3. Metabolic diseases including markers of liver disease (ALT \\> 52 U\u002Fl) and type 2 diabetes (HbA1C ≥ 6.5, fasting blood glucose ≥ 126 mg\u002Fdl)\n4. Any other disease or disorder that would influence exercise response (e.g., chronic kidney disease, dementia, current cancer diagnosis or within 2 yr remission, cerebrovascular disease)\n5. History of chemotherapy within 5 years\n6. Any current infectious disease\n7. Life expectancy \\\u003C 1 year\n8. Insulin sensitizing\u002Fblood glucose lowering agents such as metformin\n9. High dose statin (dose equivalent to ≥40 mg\u002Fd simvastatin)\n10. Lidocaine allergy\n11. Regular tobacco use and\u002For vaping\n12. Excessive alcohol consumption (3 drinks\u002Fd or 7 drinks\u002Fwk for females; 4 drinks\u002Fd or 14 drinks\u002Fwk for males)\n13. BMI \\\u003C 35.0 kg\u002Fm2\n14. Unable to commit to \\~6 months required to complete the study",true,"ALL","60 Years",{"count":86,"type":87},250,"ESTIMATED","INTERVENTIONAL",[90],"NA","Aging-related functional declines are thought to be caused by hallmark biological processes that ultimately manifest in physical, mental, and metabolic impairments that compromise healthspan and quality of life. Exercise is a multipotent treatment with promise to mitigate most aging hallmarks, but there is substantial variability in exercisƒe responsiveness. Combining endurance and resistance training in alignment with public health guidelines will be used to better understand variable exercise responsiveness in older adults with the ultimate goal of improving each older adult's capacity to attain the many health benefits of exercise.",[93,94],"Aging","Aging Well","2026-04-17",{"date":97,"type":98},"2026-04-22","ACTUAL",{"date":100,"type":98},"2025-01-27",{"date":102,"type":87},"2029-08-31",{"name":5,"class":6},2]