[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100636645":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":10,"centralContacts":37,"locations":44,"responsibleParty":60,"collaborators":62,"id":65,"slug":66,"hasResults":67,"nctId":68,"briefTitle":69,"officialTitle":69,"acronym":30,"eligibilityCriteria":70,"healthyVolunteers":71,"sex":72,"minAge":73,"maxAge":10,"enrollmentInfo":74,"targetDuration":77,"studyType":78,"phases":10,"briefSummary":79,"conditions":80,"keywords":82,"overallStatus":89,"whyStopped":10,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":99},{"fullName":5,"class":6},"University of Deusto","OTHER",[8,16],{"label":9,"type":10,"description":11,"interventionNames":12},"COPD Patients",null,"Participants diagnosed with moderate-to-severe chronic obstructive pulmonary disease (GOLD stages 2-4) will undergo multidimensional assessment of dyspnea at rest and during exertion. The protocol includes induced dyspnea using inspiratory muscle loading, neurophysiological monitoring (fNIRS), somatosensory testing (QST), placebo intervention with high-flow nasal cannula (HFNC), and immersive virtual reality scenarios.",[13,14,15],"Other: Induced Dyspnea via Inspiratory Muscle Loading","Other: Virtual Reality Sensory Immersion","Other: Placebo and Active Conditions",{"label":17,"type":10,"description":18,"interventionNames":19},"Healthy Controls","Age-, sex-, and BMI-matched healthy participants without respiratory disease will undergo the same experimental protocol, including induced dyspnea, neurophysiological measurements, somatosensory testing, placebo HFNC condition, and immersive virtual reality exposure.",[13,14,15],[21,25,31],{"type":6,"name":22,"description":23,"armGroupLabels":24,"otherNames":10},"Induced Dyspnea via Inspiratory Muscle Loading","Dyspnea will be experimentally induced using an inspiratory muscle training device (PowerBreathe) set at 40% of maximal inspiratory pressure (PImax). Participants will perform repeated breathing efforts until reaching a dyspnea intensity of 4-6 on the modified Borg scale.",[9,17],{"type":6,"name":26,"description":27,"armGroupLabels":28,"otherNames":29},"Virtual Reality Sensory Immersion","Participants will perform cycling exercise while immersed in a virtual reality environment simulating terrain with varying gradients. The visual slope will be experimentally dissociated from the actual resistance applied to the cycle ergometer to investigate expectation-driven modulation of dyspnea.",[9,17],[30],"DisVir",{"type":6,"name":32,"description":33,"armGroupLabels":34,"otherNames":35},"Placebo and Active Conditions","Participants will be exposed to three conditions: no support, placebo HFNC (simulated device without effective airflow), and active HFNC delivering room air at 30 L\u002Fmin. The intervention aims to evaluate placebo effects and expectation-related modulation of dyspnea.",[9,17],[36],"Placebo Effects",[38],{"name":39,"role":40,"phone":41,"phoneExt":42,"email":43},"Amaia Amaia Lizaso Ceciaga","CONTACT","+34-943326600","5288","amaia.lizaso@deusto.es",[45],{"facility":46,"status":10,"city":47,"state":10,"zip":48,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"Univesity of Deusto","San Sebastián","20012","Spain","ES",{"type":52,"coordinates":53},"Point",[54,55],-5.9,43.56667,{"lat":55,"lon":54},[58],{"name":39,"role":40,"phone":59,"phoneExt":42,"email":43},"34-943326600",{"type":61,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[63],{"name":64,"class":6},"Osakidetza","100636645","multidimensional-study-of-dyspnea-at-rest-during-exertion-self-induced-through-a-virtual-reality-scenario-and-its-placebo-effect-in-patients-with-copd-and-control-subjects-100636645",false,"NCT07568379","Multidimensional Study of Dyspnea at Rest, During Exertion, Self-induced Through a Virtual Reality Scenario, and Its Placebo Effect in Patients With COPD and Control Subjects.","Inclusion Criteria:\n\nCOPD:\n\n* Diagnosed COPD (FEV1\u002FFVC \\\u003C 0.7 post-bronchodilator)\n* GOLD stage 2-4\n* Clinically stable\n* Signed informed consent\n\nHealthy subjects:\n\n* Normal pulmonary function\n* No chronic diseases\n* Non-smoker or long-term ex-smoker\n\nExclusion Criteria:\n\nCOPD patients:\n\n* Severe cardiac, neurological, or psychiatric disease\n* Other respiratory diseases\n* Recent exacerbation\n* Use of ventilatory support (except CPAP)\n\nHeatlhy subjects:\n\n* Respiratory symptoms\n* Recent infections\n* Medication affecting respiratory function\n* Substance abuse",true,"ALL","18 Years",{"count":75,"type":76},80,"ESTIMATED","5 Days","OBSERVATIONAL","This quasi-experimental laboratory study aims to describe and compare the multidimensional experience of dyspnea at rest and during exertion in patients with chronic obstructive pulmonary disease (COPD) and healthy controls. The study integrates neurophysiological, somatosensory, and psychological assessments, including prefrontal cortex activity (fNIRS), quantitative sensory testing (QST), and immersive virtual reality (VR) scenarios.\n\nAdditionally, the study evaluates the modulation of dyspnea perception through expectation mechanisms and placebo intervention using high-flow nasal cannula (HFNC). The ultimate goal is to better understand the multidimensional and neurocognitive mechanisms underlying dyspnea.",[81],"COPD (Chronic Obstructive Pulmonary Disease)",[83,84,85,86,87,88],"COPD","Dyspnea","Virtual reality","fNRIS","QST","Respiratory function","NOT_YET_RECRUITING","2026-04-30",{"date":92,"type":93},"2026-05-05","ACTUAL",{"date":95,"type":76},"2026-04",{"date":97,"type":76},"2028-01",{"name":5,"class":6},1]