[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100629062":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":25,"centralContacts":30,"locations":36,"responsibleParty":54,"collaborators":25,"id":58,"slug":59,"hasResults":60,"nctId":61,"briefTitle":62,"officialTitle":62,"acronym":63,"eligibilityCriteria":64,"healthyVolunteers":60,"sex":65,"minAge":66,"maxAge":25,"enrollmentInfo":67,"targetDuration":25,"studyType":70,"phases":71,"briefSummary":73,"conditions":74,"keywords":82,"overallStatus":39,"whyStopped":25,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":95},{"fullName":5,"class":6},"Fondazione IRCCS Istituto Nazionale dei Tumori, Milano","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Structured interventions tailored to PROMs cut-off","EXPERIMENTAL","• Experimental group, which will follow a structured palliative care pathway (specific intervention defined in the protocol) based on the frailties identified at baseline PROMs (defined by cut-off).",[13],"Other: Structured Palliative Care",{"label":15,"type":16,"description":17,"interventionNames":18},"Classic Palliative Car interventions","ACTIVE_COMPARATOR","• Control group, which will undergo standard unstructured palliative care (based on PROMs as usual, but without cut-off or interventions' checklists)",[19],"Other: Classical Palliative Care",[21,26],{"type":6,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"Structured Palliative Care","Symptoms\u002Fneeds domains are defined according to protocol-specified cut-offs, followed by the activation of a tailored intervention based on structured checklists targeting the reported symptoms\u002Fneeds.",[9],null,{"type":6,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Classical Palliative Care","Multidisciplinary palliative care interventions are delivered according to usual clinical practice, without activation based on predefined cut-offs or structured algorithms.",[15],[31],{"name":32,"role":33,"phone":34,"phoneExt":25,"email":35},"Giacomo Massa, Dr","CONTACT","+39 0223903279\u002F3272","giacomo.massa@Istitutotumori.mi.it",[37],{"facility":38,"status":39,"city":40,"state":41,"zip":42,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"IRCCS Istituto Nazionale dei Tumori, Via Venezian n1","RECRUITING","Milan","Lombardy","20133","Italy","IT",{"type":46,"coordinates":47},"Point",[48,49],9.18951,45.46427,{"lat":49,"lon":48},[52],{"name":32,"role":33,"phone":34,"phoneExt":25,"email":53},"giacomo.massa@istitutotumori.mi.it",{"type":55,"investigatorFullName":56,"investigatorTitle":57,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"SPONSOR_INVESTIGATOR","Augusto Caraceni","Professor","100629062","multidisciplinary-care-pathway-tailored-on-frailty-in-cancer-patients-referred-to-outpatient-palliative-care-100629062",false,"NCT07469761","MultidISciplinary Care paThway tailoRed on frAilty in Cancer Patients Referred to Outpatient paLliative Care","MISTRAL","Inclusion Criteria:\n\n* diagnosis of advanced\u002Fmetastatic cancer\n* age \\> 18\n* Eastern Cooperative Oncology Group (ECOG) performance status ≥2\n* prognostic clinical prediction \\>1 month.\n\nExclusion Criteria:\n\n* Serious medical or psychiatric illness that can interfere with informed consent and participation in this clinical study\n* any condition that is unstable or could jeopardize the safety of the patient and their compliance in the study.","ALL","18 Years",{"count":68,"type":69},120,"ESTIMATED","INTERVENTIONAL",[72],"NA","The goal of this clinical trial is to learn whether a structured, Patient-Reported Outcome Measures (PROMs)-tailored palliative care pathway improves clinical outcomes and care experience in adults with advanced cancer referred to outpatient palliative care.\n\nPatients with advanced cancer often experience multiple symptoms and complex needs. Standard outpatient palliative care is usually guided by clinical judgment on patient-reported questionnaires. In this study, researchers aim to test whether a more structured approach, based on predefined cut-offs from PROMs, can improve symptom control, satisfaction with care, and use of healthcare resources. The main questions the study aims to answer are:\n\nDoes a structured, PROM-driven palliative care pathway reduce symptom burden and psychological distress compared with usual care? And through this, to improve patients' and caregivers' satisfaction with care or reduce emergency room visits, hospital admissions, healthcare costs, and aggressive treatments near the end of life?\n\nResearchers will compare two groups:\n\nControl group: Participants will receive standard outpatient palliative care. PROMs are collected as usual, but without predefined cut-offs or structured intervention checklists.\n\nExperimental group: Participants will receive a structured palliative care pathway tailored to symptoms\u002Fneeds identified at baseline using PROM cut-offs. Specific multidisciplinary interventions are activated according to identified needs.",[75,76,77,78,79,80,81],"Palliative Care","Palliative Care, Health Services","Patient Reported Outcome (PRO)","Patient Reported Outcome Measurements","Frailty","Cancer","Outpatient",[83,81,75,84,79,85],"Patient Reported Outcome Measurements (PROMs)","Advanced cancer","Palliative Care intervention","2026-03-09",{"date":88,"type":89},"2026-03-13","ACTUAL",{"date":91,"type":89},"2025-11-02",{"date":93,"type":69},"2027-02-28",{"name":56,"class":6},1]