[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100531625":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":30,"centralContacts":34,"locations":39,"responsibleParty":58,"collaborators":10,"id":61,"slug":62,"hasResults":63,"nctId":64,"briefTitle":65,"officialTitle":66,"acronym":10,"eligibilityCriteria":67,"healthyVolunteers":68,"sex":69,"minAge":70,"maxAge":71,"enrollmentInfo":72,"targetDuration":10,"studyType":75,"phases":10,"briefSummary":76,"conditions":77,"keywords":79,"overallStatus":42,"whyStopped":10,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":91},{"fullName":5,"class":6},"Shengjing Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"CKD Patients",null,"Participants with diagnosed Chronic Kidney Disease will undergo the same MRI protocol as the Healthy Volunteers, including T1-weighted imaging, T2-weighted imaging, MR Elastography (MRE), Intravoxel Incoherent Motion (IVIM), Arterial Spin Labeling (ASL), T1 mapping, Blood Oxygen Level Dependent (BOLD), and Diffusion Weighted Imaging (DWI). The renal MRI will be performed within 7 days of the renal biopsy. In addition to the imaging, these participants will have their blood creatinine, cystatin C, blood pressure etc., measured.",[13],"Diagnostic Test: Magnetic Resonance Imaging",{"label":15,"type":10,"description":16,"interventionNames":17},"Healthy Volunteers","Age-matched healthy individuals with no known kidney disease will be recruited. They will undergo the same MRI protocols as the CKD patient group, to establish baseline viscoelasticity parameters for comparison with the CKD patients.",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"DIAGNOSTIC_TEST","Magnetic Resonance Imaging","Both CKD patients and healthy volunteers will undergo a comprehensive MRI protocol, including T1-weighted imaging, T2-weighted imaging, Magnetic Resonance Elastography (MRE), Intravoxel Incoherent Motion (IVIM), Arterial Spin Labeling (ASL), T1 mapping, Blood Oxygen Level Dependent (BOLD), and Diffusion-Weighted Imaging (DWI) to evaluate liver and renal characteristics.\n\nFor CKD patients, renal MRI will be performed within 7 days of the renal biopsy . Additionally, blood tests for creatinine and cystatin C, along with blood pressure measurements, will be collected.",[9,15],[25,26,27,28,29],"MR elastography","Intravoxel Incoherent Motion","Arterial Spin Labeling","T1 mapping","Blood Oxygen Level Dependent",[31],{"name":32,"affiliation":5,"role":33},"yu shi, MD","PRINCIPAL_INVESTIGATOR",[35],{"name":32,"role":36,"phone":37,"phoneExt":10,"email":38},"CONTACT","189 4025 9980","18940259980@163.com",[40],{"facility":41,"status":42,"city":43,"state":44,"zip":45,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":54},"Shengjing Hospital of China Medical University","RECRUITING","Shenyang","Liaoning","110004","China","CN",{"type":49,"coordinates":50},"Point",[51,52],123.43278,41.79222,{"lat":52,"lon":51},[55],{"name":56,"role":36,"phone":57,"phoneExt":10,"email":38},"Yu Shi, MD","+8618940259980",{"type":33,"investigatorFullName":59,"investigatorTitle":60,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Yu Shi","Deputy director of department of radology","100531625","multifrequency-mre-in-evaluation-of-chronic-kidney-diseases-100531625",false,"NCT06202235","Multifrequency MRE in Evaluation of Chronic Kidney Diseases","Multifrequency Renal MR Elastography in Evaluation of Chronic Kidney Diseases: Can Shear Stiffness Evaluate Renal Fibrosis in GFR-normal Patients?","Inclusion Criteria:\n\n(1) adults with CKD defined according to the 2024 KDIGO guidelines, with either elevated SCr or abnormal proteinuria ; and (2) renal MRI was performed within 7 days of the renal biopsy.\n\nExclusion criteria:\n\n(1) genitourinary malignancy, polycystic kidney disease, renal transplantation, or acute renal failure; (2) contraindications for MRI examination; (3) poor image quality; (4) kidney deformity or severe hydronephrosis on MRI; and (5) poorly defined corticomedullary demarcation.",true,"ALL","18 Years","65 Years",{"count":73,"type":74},200,"ESTIMATED","OBSERVATIONAL","Chronic Kidney Disease (CKD) is a major public health issue, leading to high mortality and the necessity for renal replacement therapy. Kidney fibrosis, resulting from chronic damage to kidney tissue, significantly determines CKD outcomes. Kidney biopsy, the gold standard for assessing fibrosis, is invasive and limited in its ability to reflect the heterogeneous nature of fibrosis. Consequently, there is growing interest in noninvasive methods, particularly Magnetic Resonance Elastography (MRE). MRE, which evaluates tissue stiffness, has shown potential for assessing kidney fibrosis. This study aims to use multifrequency MRE to assess renal fibrosis, focusing particularly on the early stages of CKD, to enhance understanding of its progression and relationship to clinical outcomes.",[78],"Chronic Kidney Disease (CKD)",[80,81,25],"chronic kidney disease","kidney fibrosis","2026-02-07",{"date":84,"type":85},"2026-02-10","ACTUAL",{"date":87,"type":85},"2022-10-10",{"date":89,"type":74},"2027-06-08",{"name":5,"class":6},1]