[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100635864":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":28,"centralContacts":33,"locations":38,"responsibleParty":59,"collaborators":24,"id":61,"slug":62,"hasResults":63,"nctId":64,"briefTitle":65,"officialTitle":66,"acronym":67,"eligibilityCriteria":68,"healthyVolunteers":63,"sex":69,"minAge":70,"maxAge":24,"enrollmentInfo":71,"targetDuration":24,"studyType":74,"phases":75,"briefSummary":77,"conditions":78,"keywords":82,"overallStatus":40,"whyStopped":24,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":98},{"fullName":5,"class":6},"Fundacio Puigvert","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Multimodal anesthesia","ACTIVE_COMPARATOR","Multimodal anesthesia Balanced general anesthesia.\n\nStandardized multimodal analgesia:\n\nParacetamol iv NSAID or COX-2 (if not contraindicated) Magnesium sulfate iv Lidocaine iv Ketamine iv Methadone iv at the beginning surgical incision at low doses TAP block with local anesthetic: Bupivacaine 0.25% 10ml Surgical wound infiltration with local anesthetic: bupivacaine 0.25% 2ml per to knock",[13],"Drug: Multimodal anesthesia",{"label":15,"type":10,"description":16,"interventionNames":17},"Conventional anesthesia","Balanced general anesthesia.\n\nStandardized conventional analgesia:\n\nParacetamol IV NSAID or COX-2 (if not contraindicated) Analgesia based mainly on systemic opioids. Absence of protocolized regional blocking.",[18],"Drug: Conventional anesthesia",[20,25],{"type":21,"name":9,"description":22,"armGroupLabels":23,"otherNames":24},"DRUG","Administration of multimodal anesthesia in patients randomized to this arm and undergoing oncological robotic nephrectomies according to usual practice.\n\nPremedication:\n\nMidazolam: 1-2mg Ondansetron: 4-8mg IV Dexamethasone: 4-8mg IV\n\n+\u002F-Scopolamine (patients high risk PONV) iv Magnesi Sulfate: 30-50mg\u002FKg iv\n\nInduction:\n\nFentanyl: 1mcg\u002Fkg iv Propofol: 1-2mg\u002FKg iv Rocuroni: 0.3mg\u002Fkg iv Lidocaine: 1.1.5mg\u002FKg iv bolus Ketamine: 0.25-0.5mg\u002FKg Methadone: 0.5-0.1mg\u002Fkg IV at the beginning of the surgical incision (single dose).\n\nMaintenance:\n\nPropofol\u002Fsevorane Rocuroni: 0.3mg\u002Fkg\u002Fh iv Lidocaine: 1-2 mg\u002FKg\u002Fh Ketamine: 0.1-0.2 mg\u002Fkg\u002Fh\n\nPostoperative:\n\nParacetamol: 1g\u002F8h IV Metamizole: 1g\u002F8h iv Rescue opioids if VAS\\>4: Adolonta or Morphine",[9],null,{"type":21,"name":15,"description":26,"armGroupLabels":27,"otherNames":24},"Administration of conventional anesthesia in patients randomized to this arm and undergoing oncological robotic nephrectomies according to usual practice.\n\nPremedication:\n\nMidazolam: 1-2mg Ondansetron: 4-8 mg IV Dexamethasone: 4-8 mg IV\n\n+\u002F-Scopolamine (patients high risk PONV) iv\n\nInduction:\n\nFentanyl: 1mcg\u002Fkg iv Propofol: 1-2mg\u002Fkg iv Rocuroni: 0.3mg\u002Fkg iv\n\nMaintenance:\n\nPropofol\u002Fsevorane Rocuroni: 0.3mg\u002Fkg\u002Fh iv Remifentanil: 0.05-0.2 mcg\u002FKg\u002Fh Methadone: 1-1.5mg\u002Fkg IV at the end of surgery\n\nPostoperative:\n\nParacetamol: 1g\u002F8h IV Metamizole: 1g\u002F8h iv Rescue opioids if VAS\\>4: Adolonta or Morphine.",[15],[29],{"name":30,"affiliation":31,"role":32},"DIANA VERNETTA, MD","FUNDACIO PUIGVERT IUNA","PRINCIPAL_INVESTIGATOR",[34],{"name":30,"role":35,"phone":36,"phoneExt":24,"email":37},"CONTACT","0034934169700","dvernetta@fundacio-puigvert.es",[39],{"facility":5,"status":40,"city":41,"state":42,"zip":43,"country":44,"countryCode":45,"cosmosGeoPoint":46,"geoPoint":51,"contacts":52},"RECRUITING","Barcelona","BARCELONA","08025","Spain","ES",{"type":47,"coordinates":48},"Point",[49,50],2.15899,41.38879,{"lat":50,"lon":49},[53,54,58],{"name":30,"role":35,"phone":36,"phoneExt":24,"email":37},{"name":55,"role":35,"phone":56,"phoneExt":24,"email":57},"Silvia Mateu, MD","0034 934169700","smateu@fundacio-puigvert.es",{"name":30,"role":32,"phone":24,"phoneExt":24,"email":24},{"type":60,"investigatorFullName":24,"investigatorTitle":24,"investigatorAffiliation":24,"oldNameTitle":24,"oldOrganization":24},"SPONSOR","100635864","multimodal-anesthesia-in-robotic-laparoscopic-nephrectomy-100635864",false,"NCT07558226","Multimodal Anesthesia in Robotic Laparoscopic Nephrectomy","Efficacy of Multimodal Anesthesia in Robotic Laparoscopic Nephrectomy: Impact on Recovery and Early Hospital Discharge.","MANTRA","Inclusion Criteria:\n\n* Patients ≥18 years.\n* Indication for elective oncological robotic partial or radical nephrectomy.\n* ASA classification I-III.\n* Candidates for short-stay surgery according to institutional protocol.\n* Signed informed consent.\n\nExclusion Criteria:\n\n* Chronic opioid use. Defined as continuous opioid use during the 3 months prior to surgery\n* Uncontrolled chronic pain. Defined as chronic pain not adequately controlled with usual treatment during the 3 months prior to surgery.\n* Contraindications to NSAIDs, regional anesthesia, or drugs of the multimodal protocol.\n* Advanced renal failure (GFR \\\u003C30 ml\u002Fmin) at the preanesthetic visit.","ALL","18 Years",{"count":72,"type":73},80,"ESTIMATED","INTERVENTIONAL",[76],"NA","It is a prospective, randomized, controlled and superiority clinical trial, with the objective of comparing the effectiveness of multimodal anesthesia versus conventional anesthesia in patients undergoing oncological robotic nephrectomy within a short-stay surgery program (SSA). The effect of no specific drug will be evaluated, but rather the anesthetic approach ologies of surgical patients. The clinical trial will be carried out in a third-level university hospital, between the first half of 2026 and the second half of 2027 and, after approval by the corresponding Clinical Research Ethics Committee.",[79,80,81],"Anesthesia","Anesthesia and Procedure Related Time Intervals","Nephrectomy \u002F Methods",[83,84,85,79,86,87,88],"laparoscopic nephrectomy robotic","multimodal anesthesia","early hospital discharge","Multimodal","Nephrectomy","Robotic","2026-06-29",{"date":91,"type":92},"2026-07-01","ACTUAL",{"date":94,"type":92},"2026-05-02",{"date":96,"type":73},"2027-11-30",{"name":5,"class":6},1]