[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100629267":3},{"organization":4,"armGroups":7,"interventions":15,"overallOfficials":10,"centralContacts":25,"locations":10,"responsibleParty":31,"collaborators":10,"id":35,"slug":36,"hasResults":37,"nctId":38,"briefTitle":39,"officialTitle":40,"acronym":41,"eligibilityCriteria":42,"healthyVolunteers":37,"sex":43,"minAge":44,"maxAge":10,"enrollmentInfo":45,"targetDuration":10,"studyType":48,"phases":10,"briefSummary":49,"conditions":50,"keywords":55,"overallStatus":60,"whyStopped":10,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":10},{"fullName":5,"class":6},"Ankara Etlik City Hospital","OTHER_GOV",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Sepsis ICU Cohort",null,"Adult patients (≥ 18 years of age) who are admitted to the intensive care unit with sepsis or who are diagnosed with sepsis during their admission and for whom bedside renal Doppler ultrasonography is feasible will be included in the study. Participants' Renal Resistive Index (RRI) measurements will be evaluated immediately after sepsis diagnosis (T0), at 24 hours (T24), and at 48 hours (T48). Urinary \\[TIMP-2\\]\\*\\[IGFBP-7\\] measurements will be taken immediately after sepsis diagnosis (T0) and at 24 hours (T24). Clinical and laboratory data of the patients included in the study will be recorded for up to 72 hours after sepsis diagnosis. No treatment will be administered to the patients by the researchers; all medical care will be provided according to standard practice.",[13,14],"Diagnostic Test: Renal Resistive Index (RRI) Doppler Ultrasound","Diagnostic Test: Urinary TIMP-2 and IGFBP-7 biomarkers",[16,21],{"type":17,"name":18,"description":19,"armGroupLabels":20,"otherNames":10},"DIAGNOSTIC_TEST","Renal Resistive Index (RRI) Doppler Ultrasound","Doppler ultrasonography will measure RRI immediately after sepsis diagnosis (T0), at 24 hours (T24), and at 48 hours (T48).",[9],{"type":17,"name":22,"description":23,"armGroupLabels":24,"otherNames":10},"Urinary TIMP-2 and IGFBP-7 biomarkers","Urine samples for \\[TIMP-2\\]\\*\\[IGFBP-7\\] biomarker measurement will be collected immediately after sepsis diagnosis (T0) and 24 hours later (T24).",[9],[26],{"name":27,"role":28,"phone":29,"phoneExt":10,"email":30},"Eda Macit Aydın, M.D., M.D.","CONTACT","+90 312 797 00 00","edamct@hotmail.com",{"type":32,"investigatorFullName":33,"investigatorTitle":34,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Eda Macit Aydın","Intensive Care Specialist, M.D.","100629267","multimodal-approach-in-the-diagnosis-of-septic-aki-100629267",false,"NCT07472452","MULTIMODAL APPROACH IN THE DIAGNOSIS OF SEPTIC AKI","A MULTIMODAL APPROACH TO PREDICTING SEPSIS-RELATED ACUTE RENAL INJURY: A PROSPECTIVE COHORT STUDY","SEPTIC AKI","Inclusion Criteria:\n\n* Adults ≥18 years\n* Diagnosis of sepsis (per Sepsis-3 clinical criteria)\n* RRI measurement feasible at bedside\n* Informed consent from participant or legally authorized representative\n\nExclusion Criteria:\n\n* End-stage kidney disease (chronic dialysis) or baseline eGFR \\\u003C15mL\u002Fmin\u002F1.73 m²\n* Kidney transplant recipient\n* Anatomic\u002Ftechnical barrier precluding reliable renal Doppler (RRI) assessment\n* Pregnancy","ALL","18 Years",{"count":46,"type":47},130,"ESTIMATED","OBSERVATIONAL","In recent studies, it has been reported that the renal resistance index is effective in detecting sepsis-related acute renal failure (SA-AKI) in the early period. Similarly, urinary biomarkers \\[TIMP-2\\]\\*\\[IGFBP-7\\], released in response to tubular epithelial cell stress, have been reported to indicate the presence of acute renal injury (AKI) early on, before functional loss occurs (increased creatinine). This observational study aims to evaluate the renal resistance index and urinary biomarker variation in patients diagnosed with sepsis and to investigate their usefulness in the early detection of renal dysfunction that may develop after sepsis.",[51,52,53,54],"Acute Kidney Injury","Sepsis","Critical Illness","Renal Resistive Index",[56,57,58,52,59],"Renal Resistive Index (RRI)","Cell Cycle Arrest Biomarkers","Intensive Care Units","Sepsis-Associated AKI","NOT_YET_RECRUITING","2026-03-13",{"date":63,"type":64},"2026-03-16","ACTUAL",{"date":66,"type":47},"2026-03-30",{"date":68,"type":47},"2027-01-30",{"name":5,"class":6}]