[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100629359":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":30,"centralContacts":39,"locations":45,"responsibleParty":62,"collaborators":30,"id":66,"slug":67,"hasResults":68,"nctId":69,"briefTitle":70,"officialTitle":70,"acronym":30,"eligibilityCriteria":71,"healthyVolunteers":72,"sex":73,"minAge":74,"maxAge":75,"enrollmentInfo":76,"targetDuration":30,"studyType":79,"phases":80,"briefSummary":82,"conditions":83,"keywords":85,"overallStatus":48,"whyStopped":30,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":100},{"fullName":5,"class":6},"The Second Hospital of Anhui Medical University","OTHER",[8,15,20],{"label":9,"type":10,"description":11,"interventionNames":12},"Electroconvulsive Therapy (ECT) Group","EXPERIMENTAL","Participants with Major Depressive Disorder(MDD) receive active Electroconvulsive Therapy (ECT) according to the study protocol, in addition to their ongoing standardized pharmacotherapy. This group assesses the efficacy and cognitive effects of ECT.",[13,14],"Device: Electroconvulsive Therapy","Other: Cognitive and Behavioral Assessment",{"label":16,"type":10,"description":17,"interventionNames":18},"Magnetic Seizure Therapy (MST) Group","Participants with Major Depressive Disorder (MDD) receive active Magnetic Seizure Therapy (MST) according to the study protocol, in addition to their ongoing standardized pharmacotherapy. This group assesses the efficacy and cognitive effects of MST, allowing for comparison with ECT.",[19,14],"Device: Magnetic Seizure Therapy",{"label":21,"type":6,"description":22,"interventionNames":23},"Healthy Control Group","Healthy volunteers with no history of major neuropsychiatric disorders. They do not receive any neuromodulation intervention (ECT or MST) or study-related pharmacotherapy. They undergo the same cognitive and behavioral assessments at matched time points to provide normative baseline data for comparison.",[14],[25,31,35],{"type":26,"name":27,"description":28,"armGroupLabels":29,"otherNames":30},"DEVICE","Electroconvulsive Therapy","Electroconvulsive therapy will be administered two to four times a week according to a standardized protocol. Stimulation parameters (including intensity, target location, session number, and duration) will be individualized for each participant based on prior research to ensure targeted and safe delivery within established safety limits. Treatment will continue until the participant meets the protocol-defined response criteria or completes a maximum of 10 sessions.",[9],null,{"type":26,"name":32,"description":33,"armGroupLabels":34,"otherNames":30},"Magnetic Seizure Therapy","Magnetic seizure therapy will be administered two to four times a week according to a standardized protocol. Stimulation parameters (including intensity, target location, session number, and duration) will be individualized for each participant based on prior research to ensure targeted and safe delivery within established safety limits. Treatment will continue until the participant meets the protocol-defined response criteria or completes a maximum of 10 sessions.",[16],{"type":6,"name":36,"description":37,"armGroupLabels":38,"otherNames":30},"Cognitive and Behavioral Assessment","Participants will undergo a series of standardized cognitive tests (e.g., MCCB) and behavioral assessments (e.g., clinical rating scales) at specified time points. This does not constitute a therapeutic intervention but is for the purpose of data collection to establish normative baseline performance.",[9,21,16],[40],{"name":41,"role":42,"phone":43,"phoneExt":30,"email":44},"Yanghua Tian PhD","CONTACT","0551 6599 7278","zylykd@163.com",[46],{"facility":47,"status":48,"city":49,"state":50,"zip":30,"country":51,"countryCode":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":59},"Anhui Medical University","RECRUITING","Hefei","Anhui","China","CN",{"type":54,"coordinates":55},"Point",[56,57],117.28083,31.86389,{"lat":57,"lon":56},[60],{"name":41,"role":42,"phone":43,"phoneExt":30,"email":61},"ayfytyh@126.com",{"type":63,"investigatorFullName":64,"investigatorTitle":65,"investigatorAffiliation":5,"oldNameTitle":30,"oldOrganization":30},"PRINCIPAL_INVESTIGATOR","Yanghua Tian","Vice President of Anhui Medical University","100629359","multimodal-clinical-study-of-electroconvulsive-therapy-and-magnetic-seizure-therapy-100629359",false,"NCT07473648","Multimodal Clinical Study of Electroconvulsive Therapy and Magnetic Seizure Therapy","Patients Inclusion Criteria:\n\nAged 12-80 years; Diagnosis confirmed by two psychiatrists per DSM-5; Stable medication regimen pre-enrollment; Indicated for neuromodulation OR with visual field defects.\n\nPatients Exclusion Criteria:\n\nMajor systemic diseases; Prior neuromodulation within 3 months; Pregnancy or potential pregnancy; Metal implants or claustrophobia.\n\nHealthy Control Inclusion Criteria:\n\nAged 12-80 years; No history of neuropsychiatric disorders; No significant systemic diseases; Normal or corrected vision.\n\nHealthy Control Exclusion Criteria:\n\nMetal implants or claustrophobia; Ocular diseases or surgery history.",true,"ALL","12 Years","80 Years",{"count":77,"type":78},200,"ESTIMATED","INTERVENTIONAL",[81],"NA","To compare the efficacy and tolerability of Electroconvulsive Therapy (ECT) and Magnetic Seizure Therapy (MST) in patients with major depressive disorder (MDD).",[27,84,32],"Major Depressive Disorder",[86,87,88,89,90],"Electroconvulsive Therapy (ECT)","Magnetic Seizure Therapy(MST)","Major Depressive Disorder(MDD)","Electroencephalography(EEG)","Resting-state Functional MRI (fMRI)","2026-03-10",{"date":93,"type":94},"2026-03-16","ACTUAL",{"date":96,"type":94},"2025-09-01",{"date":98,"type":78},"2028-01",{"name":5,"class":6},1]