[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100620111":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":32,"centralContacts":39,"locations":48,"responsibleParty":65,"collaborators":26,"id":67,"slug":68,"hasResults":69,"nctId":70,"briefTitle":71,"officialTitle":72,"acronym":73,"eligibilityCriteria":74,"healthyVolunteers":69,"sex":75,"minAge":76,"maxAge":26,"enrollmentInfo":77,"targetDuration":26,"studyType":80,"phases":81,"briefSummary":83,"conditions":84,"keywords":90,"overallStatus":92,"whyStopped":26,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":102},{"fullName":5,"class":6},"Xuanwu Hospital, Beijing","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Multidimensional Exercise+Standard Oral Medication","EXPERIMENTAL","Participants receive a 6-week multidimensional exercise intervention (including aerobic, strength, balance, and flexibility training) combined with standard oral NSAIDs (e.g., ibuprofen or celecoxib) for 4 weeks",[13],"Behavioral: Multidimensional exercise intervention",{"label":15,"type":16,"description":17,"interventionNames":18},"Standard Oral Medication Only","ACTIVE_COMPARATOR","Active ComparatorArm Description: Participants receive standard oral NSAIDs (e.g., ibuprofen or celecoxib) for 4 weeks without any structured exercise intervention.",[19],"Drug: Oral NSAIDs",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"BEHAVIORAL","Multidimensional exercise intervention","Patients deemed by clinicians as not requiring surgical intervention and who consent to participate in the study will undergo an initial evaluation at the outpatient follow-up clinic. A multidimensional exercise intervention program and oral medication therapy (4 weeks) will be implemented based on the evaluation results.",[9],null,{"type":28,"name":29,"description":30,"armGroupLabels":31,"otherNames":26},"DRUG","Oral NSAIDs","Participants receive the same 4-week oral NSAID regimen without structured exercise intervention",[15],[33,36],{"name":34,"affiliation":5,"role":35},"Shibao Lu, MD","STUDY_CHAIR",{"name":37,"affiliation":5,"role":38},"Xiaolong Chen, MD","STUDY_DIRECTOR",[40,44],{"name":37,"role":41,"phone":42,"phoneExt":26,"email":43},"CONTACT","+8613811839409","chensmalldragon@163.com",{"name":45,"role":41,"phone":46,"phoneExt":26,"email":47},"Dongfan Wang, MD","+8618210728213","wdfdoctor@126.com",[49],{"facility":50,"status":26,"city":51,"state":52,"zip":53,"country":54,"countryCode":55,"cosmosGeoPoint":56,"geoPoint":61,"contacts":62},"Xuanwu Hospital,Capital Medical University","Beijing","Beijing Municipality","100053","China","CN",{"type":57,"coordinates":58},"Point",[59,60],116.39723,39.9075,{"lat":60,"lon":59},[63],{"name":64,"role":41,"phone":46,"phoneExt":26,"email":47},"Dongfan WANG, MD",{"type":66,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100620111","multimodal-exercise-therapy-for-non-surgical-intervention-of-nonspecific-low-back-pain-100620111",false,"NCT07353372","Multimodal Exercise Therapy for Non-Surgical Intervention of Nonspecific Low Back Pain.","Interventional Study on Paraspinal Muscle Degeneration Leading to Lumbar Degenerative Diseases","METNLBP","Inclusion Criteria:\n\n1. Age ≥ 60 years\n2. Chronic low-back pain for \\> 3 months (no surgical indication)\n3. Planned to receive conservative treatment\n4. Willing to participate and able to provide written informed consent\n\nExclusion Criteria:\n\n1. Specific low-back pain due to infection, tumour, fracture, ankylosing spondylitis, scoliosis, or other structural spinal disorders\n2. Previous lumbar surgery or current surgical indication for lumbar disease 3.Severe cardiopulmonary, hepatic or renal insufficiency that precludes exercise or drug therapy\n\n4.Severe cognitive impairment or psychiatric disorder preventing cooperation 5.Marked exercise limitations or physical disability precluding rehabilitation training 6.Participation in another clinical trial that could interfere with outcomes 7.Known hypersensitivity to any study medication","ALL","60 Years",{"count":78,"type":79},314,"ESTIMATED","INTERVENTIONAL",[82],"NA","This multicenter, assessor-blinded, two-arm parallel randomized controlled trial (N = 314) will compare the efficacy and safety of a 6-week multidimensional exercise program plus usual pharmacological care (experimental arm) versus usual pharmacological care alone (control arm) in adults ≥ 60 years with chronic non-specific low-back pain (LBP) and imaging evidence of paraspinal muscle degeneration. The primary endpoint is change in Oswestry Disability Index (ODI) at 12 months. Secondary endpoints include pain VAS, JOA score, recurrence rate, and patient satisfaction measured repeatedly to 12 months. Advanced MRI radiomics and machine-learning algorithms will be used to build a \"paraspinal muscle imaging-function-prognosis\" prediction model and an open-access web tool for risk stratification. The study will generate a standardized, evidence-based non-operative care pathway for chronic LBP driven by paraspinal muscle degeneration",[85,86,87,88,89],"Paraspinal Muscles","Low Back Pain","Machine Learning","Radiomics","Non-surgical Treatment",[91,23],"Nonsteroidal anti-inflammatory drugs","NOT_YET_RECRUITING","2026-01-19",{"date":95,"type":96},"2026-01-20","ACTUAL",{"date":98,"type":79},"2026-01-01",{"date":100,"type":79},"2028-09-01",{"name":5,"class":6},1]