[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100550611":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":30,"locations":36,"responsibleParty":66,"collaborators":68,"id":72,"slug":73,"hasResults":74,"nctId":75,"briefTitle":76,"officialTitle":76,"acronym":77,"eligibilityCriteria":78,"healthyVolunteers":74,"sex":79,"minAge":80,"maxAge":81,"enrollmentInfo":82,"targetDuration":26,"studyType":85,"phases":86,"briefSummary":88,"conditions":89,"keywords":26,"overallStatus":39,"whyStopped":26,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":100},{"fullName":5,"class":6},"University of New Mexico","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Active iTBS","ACTIVE_COMPARATOR","Participants in this arm will undergo 50 sessions of active accelerated (10x\u002Fday, five days) image-guided iTBS.",[13],"Device: Active Intermittent theta burst stimulation",{"label":15,"type":16,"description":17,"interventionNames":18},"Sham iTBS","SHAM_COMPARATOR","Participants in this arm will undergo 50 sessions of sham accelerated (10x\u002Fday, five days) image-guided iTBS.",[19],"Device: Sham Intermittent theta burst stimulation",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DEVICE","Active Intermittent theta burst stimulation","Intermittent theta burst stimulation (iTBS) is an efficient form of transcranial magnetic stimulation that allows up to 10x more pulses to be delivered in a given timeframe compared to conventional stimulation patterns.",[9],null,{"type":22,"name":28,"description":24,"armGroupLabels":29,"otherNames":26},"Sham Intermittent theta burst stimulation",[15],[31],{"name":32,"role":33,"phone":34,"phoneExt":26,"email":35},"Davin Quinn, MD","CONTACT","505-272-9494","dquinn@salud.unm.edu",[37,55],{"facility":38,"status":39,"city":40,"state":41,"zip":42,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"UNM Center for Psychiatric Research","RECRUITING","Albuquerque","New Mexico","87106","United States","US",{"type":46,"coordinates":47},"Point",[48,49],-106.65114,35.08449,{"lat":49,"lon":48},[52,53],{"name":32,"role":33,"phone":34,"phoneExt":26,"email":35},{"name":32,"role":54,"phone":26,"phoneExt":26,"email":26},"PRINCIPAL_INVESTIGATOR",{"facility":56,"status":39,"city":40,"state":41,"zip":57,"country":43,"countryCode":44,"cosmosGeoPoint":58,"geoPoint":60,"contacts":61},"New Mexico VA Health Care System","87108",{"type":46,"coordinates":59},[48,49],{"lat":49,"lon":48},[62],{"name":63,"role":33,"phone":64,"phoneExt":65,"email":26},"Tiana Maple","505-265-1711","4935",{"type":67,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR",[69],{"name":70,"class":71},"New Mexico VA Healthcare System","FED","100550611","multimodal-image-analysis-and-guidance-of-neuromodulation-for-trauma-related-symptoms-100550611",false,"NCT06449326","Multimodal Image Analysis and Guidance of Neuromodulation for Trauma-Related Symptoms","MAGNETS","Inclusion Criteria:\n\n* Veterans will be enrolled in this study if they:\n\n  1. are aged 18-80;\n  2. have a documented diagnosis of PTSD with evidence of ongoing symptoms as demonstrated by score of \"31\" or higher on the PCL-5, a measure of posttraumatic stress symptoms;\n  3. are fluent in English (as the neuropsychological testing tools used are only available in English) and\n  4. have been on stable doses of psychotropic medications for the past month.\n\nExclusion Criteria:\n\n* Veterans will be excluded from participation in this study if there is:\n\n  1. a prior history of other neurological disease beyond mild TBI, as determined by VA\u002FDoD criteria for TBI severity;\n  2. any history of seizures beyond immediate posttraumatic seizure or childhood febrile seizure, so as to reduce risk of exacerbation of epilepsy or other neurological symptoms;\n  3. history of a psychotic disorder, such as schizophrenia or bipolar disorder, so as to reduce risk of psychiatric decompensation;\n  4. active substance\u002Falcohol dependence without ongoing treatment, to reduce confounding effects on diagnosis and brain imaging;\n  5. presence of any implanted electrical device (e.g., pacemaker), to reduce risk of device malfunction from rTMS;\n  6. recent medical hospitalization (within four weeks), to reduce risk of medical decompensation during the study;\n  7. any condition that would prevent the subject from completing the protocol;\n  8. appointment of a legal representative or inability to provide informed consent, to avoid coercion of a vulnerable population;\n  9. any ongoing litigation related to PTSD, TBI, disability determination, or service connection, to prevent interference with legal proceedings;\n  10. any contraindication to MRI;\n  11. pregnant women, so as to prevent complications;\n  12. membership in an identified vulnerable population, including minors and prisoners, so as to prevent coercion;\n  13. Cognitively impaired adults who lack capacity to consent.","ALL","18 Years","80 Years",{"count":83,"type":84},64,"ESTIMATED","INTERVENTIONAL",[87],"NA","MAGNETS is a prospective, randomized, parallel-design, sham-controlled clinical trial of accelerated, functional magnetic resonance imaging (fMRI)-guided intermittent theta burst stimulation (iTBS) to the right dorsolateral prefrontal cortex (dlPFC) for chronic symptoms of posttraumatic stress disorder (PTSD) in a comorbid Veteran population.",[90],"Posttraumatic Stress Disorder","2025-07-01",{"date":93,"type":94},"2025-07-02","ACTUAL",{"date":96,"type":94},"2024-06-01",{"date":98,"type":84},"2027-10-01",{"name":5,"class":6},2]