[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100603202":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":12,"centralContacts":16,"locations":21,"responsibleParty":40,"collaborators":10,"id":43,"slug":44,"hasResults":45,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":10,"eligibilityCriteria":49,"healthyVolunteers":45,"sex":50,"minAge":51,"maxAge":10,"enrollmentInfo":52,"targetDuration":10,"studyType":55,"phases":10,"briefSummary":56,"conditions":57,"keywords":59,"overallStatus":65,"whyStopped":10,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":75},{"fullName":5,"class":6},"Shanghai Jiao Tong University Affiliated Sixth People's Hospital","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":10},"Patients with moderate to severe stenosis (stenosis degree: 70% ~ 99%) in both intracranial and extr",null,"Patients with moderate to severe stenosis (stenosis degree: 70% \\~ 99%) in both intracranial and extracranial arteries were considered for enrollment in this study.",[13],{"name":14,"affiliation":5,"role":15},"Yueqi Zhu, MD","PRINCIPAL_INVESTIGATOR",[17],{"name":14,"role":18,"phone":19,"phoneExt":10,"email":20},"CONTACT","0086-21-64844183","zhuyueqi@hotmail.com",[22],{"facility":23,"status":10,"city":24,"state":10,"zip":25,"country":26,"countryCode":27,"cosmosGeoPoint":28,"geoPoint":33,"contacts":34},"Shanghai 6th People's Hospital","Shanghai","200023","China","CN",{"type":29,"coordinates":30},"Point",[31,32],121.45806,31.22222,{"lat":32,"lon":31},[35,39],{"name":36,"role":18,"phone":37,"phoneExt":10,"email":38},"Yue-Qi Zhu, MD","0086-021-64844183","zyq1111@126.com",{"name":36,"role":15,"phone":10,"phoneExt":10,"email":10},{"type":15,"investigatorFullName":41,"investigatorTitle":42,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Yueqi Zhu","Professor","100603202","multimodal-imaging-evaluation-of-vulnerability-of-atherosclerotic-plaques-a-comparison-of-hr-vwi-oct-and-rws-100603202",false,"NCT07133451","Multimodal Imaging Evaluation of Vulnerability of Atherosclerotic Plaques: A Comparison of HR-VWI, OCT, and RWS","Prospective Cohort Registry Study on Multimodal Imaging Evaluation of Vulnerability of Intracranial and Extracranial Atherosclerotic Plaques: A Comparison of HR-VWI, OCT, and RWS","Inclusion Criteria:\n\n* At least 18 years old;\n* Severe stenosis of intracranial arteries (stenosis degree: 70% \\~ 99%, traditional angiography is required to confirm the degree of stenosis according to the criteria of Warfarin-Aspirin Symptomatic Intracranial Disease (WASID) study);\n* Carry out cerebral angiography and OCT within one week after HR-VWI examination;\n* The patient or the legal representative of the patient is able and willing to sign an informed consent form.\n\nExclusion Criteria:\n\n* Non-atherosclerotic intracranial and extracranial artery stenosis, such as dissection, smoke disease, etc.;\n* There are contraindications to MRI, such as claustrophobia, metal implants, etc.; Renal insufficiency, elevated serum creatinine (more than twice the upper limit of normal);\n* Patients with severe cardiopulmonary diseases were considered unsuitable for this study;\n* Allergy to iodine or gadolinium contrast agent;\n* Participants who were unable to complete the study due to mental illness, cognitive or emotional disorder.","ALL","18 Years",{"count":53,"type":54},561,"ESTIMATED","OBSERVATIONAL","The primary objective of this study is to evaluate the vulnerability of intracranial and extracranial atherosclerotic plaques using HR-VWI, OCT, and RWS technologies, while exploring correlations among these three imaging techniques. Secondary objectives include: 1) Investigating the relationship between RWS and plaque progression and identifying optimal RWS predictors; 2) Further evaluating the clinical value of RWS and HR-VWI in stroke prediction through two-year clinical and HR-VWI follow-up evaluations.",[58],"Intracranial Atherosclerotic Stenosis",[60,61,62,63,64],"high resolution magnetic resonance imaging","intracranial atherosclerotic stenosis","atherosclerotic Plaques","radial Wall Strain","optical Coherence Tomography","NOT_YET_RECRUITING","2025-08-13",{"date":68,"type":69},"2025-08-21","ACTUAL",{"date":71,"type":54},"2025-08-10",{"date":73,"type":54},"2030-06-30",{"name":5,"class":6},1]