[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100550883":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":24,"centralContacts":28,"locations":33,"responsibleParty":51,"collaborators":10,"id":54,"slug":55,"hasResults":56,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":10,"eligibilityCriteria":60,"healthyVolunteers":61,"sex":62,"minAge":63,"maxAge":64,"enrollmentInfo":65,"targetDuration":10,"studyType":68,"phases":10,"briefSummary":69,"conditions":70,"keywords":72,"overallStatus":35,"whyStopped":10,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":84},{"fullName":5,"class":6},"Shengjing Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"DKD Patients",null,"Participants with diagnosed Diabetic Kidney Disease (DKD) will undergo the same MRI protocol as the Healthy Volunteers, including Blood Oxygen Level Dependence (BOLD), Intravoxel Incoherent Motion (IVIM), Arterial Spin Labeling (ASL), T1\\&T2-mapping imaging, and Magnetic Resonance Elastography (MRE). In addition to the imaging, these participants will have their blood creatinine, cystatin C, blood pressure, and urine albumin-to-creatinine ratio (UACR) measured within 3 days before and after the MRE. A renal biopsy will be performed in a subset of these participants as part of their clinical assessment to evaluate the extent of kidney damage.",[13],"Diagnostic Test: Magnetic Resonance Imaging",{"label":15,"type":10,"description":16,"interventionNames":17},"Healthy Volunteers","Age-matched healthy individuals with no known kidney disease will be recruited. They will undergo the same MRI protocols as the DKD group, including Blood Oxygen Level Dependence (BOLD), Intravoxel Incoherent Motion (IVIM), Arterial Spin Labeling (ASL), T1\\&T2-mapping imaging and Magnetic Resonance Elastography (MRE), to establish baseline viscoelasticity parameters for comparison with the Diabetics.",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":10},"DIAGNOSTIC_TEST","Magnetic Resonance Imaging","Both Diabetic Kidney Disease (DKD) patients and Healthy Volunteers will undergo MRI protocols including Blood Oxygen Level Dependence (BOLD), Intravoxel Incoherent Motion (IVIM), Arterial Spin Labeling (ASL), T1\\&T2-mapping imaging and Magnetic Resonance Elastography (MRE). For Diabetics, blood tests for creatinine and cystatin C, urine test for albumin-to-creatinine ratio (UACR), along with blood pressure measurements, will be taken within a three-day window surrounding the MRE test. Additionally, Diabetics will undergo a renal biopsy to assess the extent of kidney damage.",[9,15],[25],{"name":26,"affiliation":5,"role":27},"Yu Shi, M.D.","PRINCIPAL_INVESTIGATOR",[29],{"name":26,"role":30,"phone":31,"phoneExt":10,"email":32},"CONTACT","18940259980","18940259980@163.com",[34],{"facility":5,"status":35,"city":36,"state":37,"zip":38,"country":39,"countryCode":40,"cosmosGeoPoint":41,"geoPoint":46,"contacts":47},"RECRUITING","Shenyang","Liaoning","110004","China","CN",{"type":42,"coordinates":43},"Point",[44,45],123.43278,41.79222,{"lat":45,"lon":44},[48],{"name":49,"role":30,"phone":50,"phoneExt":10,"email":32},"Yu Shi, docter","+8618940259980",{"type":27,"investigatorFullName":52,"investigatorTitle":53,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Yu Shi","Deputy director of department of radiology","100550883","multimodal-magnetic-resonance-imaging-in-evaluation-of-diabetic-kidney-disease-100550883",false,"NCT06452862","Multimodal Magnetic Resonance Imaging in Evaluation of Diabetic Kidney Disease","the Value of Multimodal Magnetic Resonance Imaging in the Diagnosis and Treatment Monitoring of Diabetic Kidney Disease","Inclusion Criteria:\n\n* Clinically diagnosed diabetic kidney disease (DKD)\n* Age 18-80 years\n\nExclusion Criteria:\n\n* Malignant tumor, active infection, or life expectancy \\\u003C1 year\n* Pregnancy or lactation\n* MRE contraindications (metal implants, claustrophobia, severe arrhythmia) or poor image quality\n* eGFR \\\u003C15 mL\u002Fmin\u002F1.73m² or receiving renal replacement therapy\n* Other primary kidney diseases or systemic diseases affecting renal function",true,"ALL","18 Years","80 Years",{"count":66,"type":67},150,"ESTIMATED","OBSERVATIONAL","The goal of this study is to investigate the value of noninvasive evaluation of multimodal magnetic resonance imaging in diagnosis and treatment of diabetic kidney disease (DKD). We aim to explore the feasibility of multimodal magnetic resonance imaging in the staging diagnosis of DKD, and establish a non-invasive method for evaluating the progression of DKD disease by combining imaging and biochemical indicators. Multimodal magnetic resonance examinations will be performed on diabetic patients with different stages as well as regular follow-up during treatment, in order to investigate the relationship between imaging findings and pathophysiological changes of the kidneys.",[71],"Diabetic Kidney Disease",[71,21,73,74],"Magnetic Resonance Elastography","Diabetes","2026-04-06",{"date":77,"type":78},"2026-04-13","ACTUAL",{"date":80,"type":78},"2024-06-06",{"date":82,"type":67},"2028-06-06",{"name":5,"class":6},1]