[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100628708":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":18,"centralContacts":27,"locations":37,"responsibleParty":60,"collaborators":63,"id":66,"slug":67,"hasResults":68,"nctId":69,"briefTitle":70,"officialTitle":71,"acronym":18,"eligibilityCriteria":72,"healthyVolunteers":68,"sex":73,"minAge":74,"maxAge":18,"enrollmentInfo":75,"targetDuration":18,"studyType":78,"phases":79,"briefSummary":81,"conditions":82,"keywords":86,"overallStatus":40,"whyStopped":18,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":101},{"fullName":5,"class":6},"University of Iceland","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Prehabilitation group","EXPERIMENTAL","This arm will undergo the intervention (multimodal prehabilitation).",[13],"Other: Multimodal Prehabilitation",{"label":15,"type":16,"description":17,"interventionNames":18},"Control group","NO_INTERVENTION","This arm will be the control group and will not undergo the intervention (prehabilitation). The standard of care for patients undergoing elective prosthesis surgery who present at the perioperative services prior to surgery includes a preoperative appointment with a physiotherapist to guide postoperative recovery and the use of assistive devices, a consultation with a nurse to review preoperative hygiene measures such as showering, and a telephone consultation with an anesthetist for preoperative evaluation, risk assessment, and review of routine laboratory tests (e.g., blood work). As part of this process, medications, including blood thinners and anticoagulants, are adjusted as needed. In addition, patients receive education regarding perioperative management and anesthesia, with further work-up performed on an as-needed basis. Usually, patients present within 1-4 weeks before surgery.",null,[20],{"type":6,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"Multimodal Prehabilitation","The intervention will begin ≥2 months before planned surgery and consists of a multimodal prehabilitation program. Participants will undergo geriatric assessment with frailty evaluation, medication review, and optimization of comorbidities as needed. Patients at risk of malnutrition will receive nutritional assessment, counseling, and supplementation when indicated.\n\nAll participants will receive individualized physiotherapy based on the Otago Exercise Programme, including strength, balance, and walking exercises. Patients will attend an initial physiotherapy session with follow-up visits and will be encouraged to perform exercises at home multiple times per week at moderate intensity.",[9],[25,26],"Prehabilitation","Preoperative Optimization",[28,33],{"name":29,"role":30,"phone":31,"phoneExt":18,"email":32},"Martin I Sigurdsson, MD, PhD","CONTACT","+354-824-8282","mingi@hi.is",{"name":34,"role":30,"phone":35,"phoneExt":18,"email":36},"Luis G Rabelo, MD","+3548203587","lgr2@hi.is",[38],{"facility":39,"status":40,"city":41,"state":18,"zip":42,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"Landspitali University hospital","RECRUITING","Reykjavik","101","Iceland","IS",{"type":46,"coordinates":47},"Point",[48,49],-21.89541,64.13548,{"lat":49,"lon":48},[52,55,58],{"name":34,"role":30,"phone":53,"phoneExt":54,"email":36},"8203587","+354",{"name":29,"role":30,"phone":56,"phoneExt":54,"email":57},"8248282","martin@landspitali.is",{"name":29,"role":59,"phone":18,"phoneExt":18,"email":18},"PRINCIPAL_INVESTIGATOR",{"type":59,"investigatorFullName":61,"investigatorTitle":62,"investigatorAffiliation":5,"oldNameTitle":18,"oldOrganization":18},"Martin Ingi Sigurdsson","Professor in Anesthesiology and Intensive Care",[64],{"name":65,"class":6},"Landspitali University Hospital","100628708","multimodal-prehabilitation-of-frail-patients-undergoing-elective-knee-or-hip-replacement-100628708",false,"NCT07465159","Multimodal Prehabilitation of Frail Patients Undergoing Elective Knee or Hip Replacement","Multimodal Prehabilitation of Frail Patients 70 Years and Older Undergoing Elective Knee or Hip Replacement: A Pilot Randomized Controlled Trial","Inclusion Criteria:\n\n* Patients aged 70 years or older assigned to undergo hip\u002Fknee replacement at Landspítali University Hospital.\n* Inclusion will be offered to patients who have previously presented at the outpatient orthopedic department and been scheduled for an elective (with a waiting period ≥2 months before surgery) hip\u002Fknee replacement.\n* Patients who are willing to participate and sign informed consent and are willing to be randomized to the control or intervention arm.\n\nExclusion Criteria:\n\n* Patients who screen negative for all frailty tools will be excluded from the study.\n* Patients who are already in active physiotherapy, meeting with a physiotherapist \\>1 every month, will also be excluded.\n* In addition, those who do not undergo planned surgery, are undergoing redo hip\u002Fknee prosthesis replacement will be excluded","ALL","70 Years",{"count":76,"type":77},50,"ESTIMATED","INTERVENTIONAL",[80],"NA","Background: Frailty is a geriatric syndrome of reduced physiologic reserve that increases surgical risk and is common among older adults undergoing hip or knee replacement. While prehabilitation has shown promise in enhancing outcomes, evidence from randomized controlled trials (RCTs) in frail orthopedic patients is limited.\n\nObjective: This study aims to evaluate the feasibility and preliminary data on the effectiveness of a multimodal prehabilitation program for frail patients undergoing elective hip or knee arthroplasty.\n\nMethods: A pilot RCT will be conducted at Landspítali-University Hospital. Patients ≥70 years scheduled for surgery with ≥2 months waiting time will be screened for frailty using PRISMA-7, the Clock Drawing Test, and Timed Up \\& Go. Patients screening positive for any of the three screening tools will be randomized to multimodal prehabilitation or standard of care. The intervention includes comprehensive geriatric assessment, medication review, tailored physiotherapy using the Otago Exercise Programme, and nutritional counseling if at risk of malnutrition. We will conduct an external pilot for feasibility measures (overall enrollment, recruitment, retention, adherence). Secondary outcomes include physical performance, postoperative complications, patient-reported health status (WOMAC scale) and quality of life (EQ-5D-5L ), length of primary hospital stay, discharge location, falls postoperatively, 180-day readmission and 180-day mortality.\n\nSignificance: This trial may aid in the design of larger RCT study and provide a signal of the role of multimodal prehabilitation on outcomes, including quality of life and health status among frail arthroplasty patients.",[83,25,84,85],"Frailty Syndrome","Arthroplasties, Knee Replacement","Arthroplasties, Hip Replacement",[87,88,25,89,90,91],"Frailty","Arthroplasty","Multimodal prehabilitation","Knee replacement","Hip replacement","2026-04-01",{"date":94,"type":95},"2026-04-07","ACTUAL",{"date":97,"type":95},"2026-03-20",{"date":99,"type":77},"2027-12-31",{"name":5,"class":6},1]