[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100558219":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":10,"centralContacts":20,"locations":30,"responsibleParty":53,"collaborators":10,"id":55,"slug":56,"hasResults":57,"nctId":58,"briefTitle":59,"officialTitle":59,"acronym":10,"eligibilityCriteria":60,"healthyVolunteers":57,"sex":61,"minAge":62,"maxAge":10,"enrollmentInfo":63,"targetDuration":66,"studyType":67,"phases":10,"briefSummary":68,"conditions":69,"keywords":72,"overallStatus":32,"whyStopped":10,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":85},{"fullName":5,"class":6},"Jinan Central Hospital","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Patients with acute ischemic stroke and atrial fibrillation",null,"Adult patients with an acute ischemic stroke and atrial fibrillation will undergo a baseline work-up and cardiologic work-up. Baseline work-up includes admission 12-lead ECG，blood analysis, brain CT\u002FMRI, brain CTA\u002FMRA\u002Fvessel ultrasound. Cardiologic work-up includes prolonged ECG monitoring, echocardiography and cardiac CTA. Treatment will follow the current guidelines.",[13],"Diagnostic Test: Cardiologic work-up",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":10},"DIAGNOSTIC_TEST","Cardiologic work-up","Noninvasive prolonged ECG monitoring with a duration of 7 days measuring AF burden； Echocardiography measuring LA volume or volume index, LA diameter or diameter index； Cardiac CTA measuring LAA morphologies, cardiac thrombus.",[9],[21,26],{"name":22,"role":23,"phone":24,"phoneExt":10,"email":25},"Liqun Jiao","CONTACT","13911224991","liqunjiao@sina.cn",{"name":27,"role":23,"phone":28,"phoneExt":10,"email":29},"Guohai Su","19953193319","suguohai1@126.com",[31],{"facility":5,"status":32,"city":33,"state":34,"zip":35,"country":36,"countryCode":37,"cosmosGeoPoint":38,"geoPoint":43,"contacts":44},"RECRUITING","Jinan","Shandong","250013","China","CN",{"type":39,"coordinates":40},"Point",[41,42],116.99722,36.66833,{"lat":42,"lon":41},[45,49],{"name":46,"role":23,"phone":47,"phoneExt":10,"email":48},"Yanxin Zhao","+86 13370582882","13370582882@163.com",{"name":50,"role":23,"phone":51,"phoneExt":10,"email":52},"Wencheng Kong","+86 15614656050","kongwencheng@163.com",{"type":54,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100558219","multimodal-prognostic-assessment-of-acute-ischemic-stroke-patients-with-atrial-fibrillation-a-prospective-multicenter-observational-study-iat-closure-100558219",false,"NCT06548269","Multimodal Prognostic Assessment of Acute Ischemic Stroke Patients With Atrial Fibrillation: a Prospective, Multicenter, Observational Study (IAT-CLOSURE)","Inclusion Criteria:\n\n1. Age \\> 18 years old；\n2. Acute ischemic stroke with onset ≤ 14 days；\n3. Previously or during this hospitalization diagnosed with non-valvular atrial fibrillation;\n4. Informed consent obtained from the patient or his\u002Fher legal representative；\n\nExclusion Criteria:\n\n1. Pacemaker, implantable cardioverter defibrillator or implantable cardiac monitor;\n2. Left atrial appendage has been removed or post occlusion device implantation;\n3. Transient AF secondary to other reversible disorders；\n4. Life expectancy less than 1 year;\n5. Patients that cannot complete subsequent follow-up (e.g. no fixed residence, overseas patients, etc.);\n6. Females who are pregnant or in lactation;\n7. Participating in other clinical trials that could confound the evaluation of the study;\n8. Other circumstances that the investigator considers inappropriate for participation or may pose a significant risk to patients.","ALL","18 Years",{"count":64,"type":65},1000,"ESTIMATED","3 Years","OBSERVATIONAL","The main purpose of this study is to investigate the safety and outcomes of different treatment strategies, including best medical therapy (OAC \\[oral anticoagulation\\], antiplatelet \\[APT\\]) and left atrial appendage closure \\[LAAC\\] in acute ischemic stroke (AIS) patients with atrial fibrillation (AF) based on multimodal assessment from combined brain and cardiologic work-up, and to optimize secondary prevention.",[70,71],"Acute Ischemic Stroke","Atrial Fibrillation",[70,73,74,75],"Atrial fibrillation","AF burden","Left atrial appendage closure","2025-05-19",{"date":78,"type":79},"2025-05-22","ACTUAL",{"date":81,"type":79},"2024-11-15",{"date":83,"type":65},"2029-05-31",{"name":5,"class":6},1]