[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100630559":3},{"organization":4,"armGroups":7,"interventions":22,"overallOfficials":10,"centralContacts":33,"locations":39,"responsibleParty":58,"collaborators":10,"id":62,"slug":63,"hasResults":64,"nctId":65,"briefTitle":66,"officialTitle":67,"acronym":10,"eligibilityCriteria":68,"healthyVolunteers":69,"sex":70,"minAge":71,"maxAge":72,"enrollmentInfo":73,"targetDuration":10,"studyType":76,"phases":10,"briefSummary":77,"conditions":78,"keywords":81,"overallStatus":41,"whyStopped":10,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":89,"completionDateStruct":90,"leadSponsor":92,"locationsCount":93},{"fullName":5,"class":6},"Kayseri City Hospital","OTHER_GOV",[8,14,18],{"label":9,"type":10,"description":11,"interventionNames":12},"Lymphedema Group",null,"Patients clinically diagnosed with lower extremity lymphedema. Participants in this group will undergo a non-invasive multimodal ultrasound assessment (including B-mode, strain elastography, power Doppler, and ImageJ analysis) to evaluate tissue characteristics.",[13],"Diagnostic Test: Multimodal Ultrasound Assessment",{"label":15,"type":10,"description":16,"interventionNames":17},"Lipedema Group","Patients clinically diagnosed with lipedema of the lower extremities. Participants in this group will undergo the identical non-invasive multimodal ultrasound assessment protocol to evaluate tissue echogenicity, thickness, and stiffness.",[13],{"label":19,"type":10,"description":20,"interventionNames":21},"Healthy Control Group","Healthy volunteers with no history or clinical signs of chronic lower extremity edema, lymphedema, or lipedema. This group will undergo the same multimodal ultrasound assessment to establish baseline normative values for comparison.",[13],[23],{"type":24,"name":25,"description":26,"armGroupLabels":27,"otherNames":28},"DIAGNOSTIC_TEST","Multimodal Ultrasound Assessment","A comprehensive, non-invasive ultrasonographic evaluation of the lower extremities. The protocol includes B-mode ultrasound for measuring dermis and subcutaneous tissue thickness, strain elastography for assessing tissue biomechanical stiffness, and Power Doppler for evaluating local microvascularity. Additionally, quantitative echogenicity of the tissues will be analyzed using ImageJ software.",[19,15,9],[29,30,31,32],"B-mode Ultrasonography","Strain Elastography","Power Doppler","ImageJ Analysis",[34],{"name":35,"role":36,"phone":37,"phoneExt":10,"email":38},"Abdullah Goktug Yazar","CONTACT","+905309731140","abdullahgoktug.yazar@sbu.edu.tr",[40],{"facility":5,"status":41,"city":42,"state":43,"zip":44,"country":45,"countryCode":10,"cosmosGeoPoint":46,"geoPoint":51,"contacts":52},"RECRUITING","Kayseri","Kocasinan","38080","Turkey (Türkiye)",{"type":47,"coordinates":48},"Point",[49,50],35.48528,38.73222,{"lat":50,"lon":49},[53,55],{"name":54,"role":36,"phone":37,"phoneExt":10,"email":38},"Abdullah Goktug Yazar, MD",{"name":56,"role":57,"phone":10,"phoneExt":10,"email":10},"Ayse Guc, MD","SUB_INVESTIGATOR",{"type":59,"investigatorFullName":60,"investigatorTitle":61,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Ayse Guc","Uz. Dr.","100630559","multimodal-ultrasound-for-differentiating-lymphedema-and-lipedema-100630559",false,"NCT07489248","Multimodal Ultrasound for Differentiating Lymphedema and Lipedema","ULTRASONOGRAPHIC EVALUATION OF LOWER EXTREMITY SKIN AND SUBCUTANEOUS TISSUE WITH QUANTITATIVE ECHOGENICITY AND ELASTOGRAPHY IN LYMPHEDEMA, LIPEDEMA, AND HEALTHY CONTROL GROUPS: A CONTROLLED CLINICAL STUDY","Inclusion Criteria:\n\nIndividuals aged 18 to 75 years.\n\nClinical diagnosis of lower extremity lymphedema (for the lymphedema group).\n\nClinical diagnosis of lower extremity lipedema (for the lipedema group).\n\nHealthy individuals with no history or clinical signs of chronic lower extremity edema (for the control group).\n\nExclusion Criteria:\n\nPresence of active local infections, such as cellulitis or erysipelas, in the lower extremities.\n\nHistory of deep vein thrombosis (DVT) or severe chronic venous insufficiency.\n\nSystemic conditions that can cause secondary edema, including congestive heart failure, chronic kidney disease, or severe hepatic impairment.\n\nPrevious surgical interventions on the affected lower extremities, including liposuction, lymphatic reconstructive surgery, or major orthopedic surgeries.\n\nActive malignancy or currently undergoing radiotherapy\u002Fchemotherapy.\n\nPregnancy or lactation.",true,"FEMALE","18 Years","75 Years",{"count":74,"type":75},75,"ESTIMATED","OBSERVATIONAL","The aim of this observational study is to evaluate the diagnostic value of multimodal ultrasonography in differentiating between lymphedema and lipedema. Differentiating these two chronic conditions based solely on clinical examination can be challenging due to overlapping symptoms. This study will utilize various non-invasive ultrasound techniques-including B-mode ultrasound, strain elastography, power Doppler, and quantitative ImageJ analysis-to compare tissue characteristics among patients with lymphedema, patients with lipedema, and healthy controls. The goal is to identify reliable, non-invasive imaging biomarkers that can facilitate early and accurate diagnosis, thereby optimizing patient management.",[79,80],"Lymphedema","Lipedema",[82,30,83,31,32,84],"Multimodal Ultrasonography","Differential Diagnosis","Subcutaneous Tissue","2026-03-19",{"date":87,"type":88},"2026-03-24","ACTUAL",{"date":85,"type":88},{"date":91,"type":75},"2026-09-15",{"name":5,"class":6},1]