[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100474379":3},{"organization":4,"armGroups":7,"interventions":15,"overallOfficials":27,"centralContacts":31,"locations":41,"responsibleParty":61,"collaborators":21,"id":64,"slug":65,"hasResults":66,"nctId":67,"briefTitle":68,"officialTitle":69,"acronym":21,"eligibilityCriteria":70,"healthyVolunteers":66,"sex":71,"minAge":72,"maxAge":73,"enrollmentInfo":74,"targetDuration":21,"studyType":77,"phases":78,"briefSummary":80,"conditions":81,"keywords":83,"overallStatus":44,"whyStopped":21,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":96},{"fullName":5,"class":6},"Rady Pediatric Genomics & Systems Medicine Institute","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Enrollees - WGS","EXPERIMENTAL","These participants will be subject to whole genome sequencing and Phage ImmunoPrecipiation sequencing (PhIP-Seq) to identify genetic changes and novel antibodies associated with psychosis.",[13,14],"Genetic: Genetic: Genomic sequencing and molecular diagnostic results, if any.","Diagnostic Test: Phage display ImmunoPrecipiation Sequencing (PhIP-Seq)",[16,22],{"type":17,"name":18,"description":19,"armGroupLabels":20,"otherNames":21},"GENETIC","Genetic: Genomic sequencing and molecular diagnostic results, if any.","Genomic sequencing results may be used for diagnosis and treatment of participants.",[9],null,{"type":23,"name":24,"description":25,"armGroupLabels":26,"otherNames":21},"DIAGNOSTIC_TEST","Phage display ImmunoPrecipiation Sequencing (PhIP-Seq)","Whole Proteome programmable phage display immunoprecipitation sequencing will be used to diagnose known and novel autoantibodies.",[9],[28],{"name":29,"affiliation":5,"role":30},"Aaron Besterman, MD","PRINCIPAL_INVESTIGATOR",[32,37],{"name":29,"role":33,"phone":34,"phoneExt":35,"email":36},"CONTACT","858-576-1700","221633","abesterman@health.ucsd.edu",{"name":38,"role":33,"phone":34,"phoneExt":39,"email":40},"Corrine Blucher, BS","221632","cblucher@rchsd.org",[42],{"facility":43,"status":44,"city":45,"state":46,"zip":47,"country":48,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":56},"Rady Children's Hospital San Diego","RECRUITING","San Diego","California","92123","United States","US",{"type":51,"coordinates":52},"Point",[53,54],-117.16472,32.71571,{"lat":54,"lon":53},[57,59],{"name":58,"role":33,"phone":34,"phoneExt":35,"email":36},"Aaron Besterman, MD, MD",{"name":38,"role":33,"phone":60,"phoneExt":39,"email":40},"8585761700",{"type":30,"investigatorFullName":62,"investigatorTitle":63,"investigatorAffiliation":5,"oldNameTitle":21,"oldOrganization":21},"Aaron Besterman","Psychiatrist, Clinical Investigator","100474379","multiomic-diagnostics-in-youth-with-psychosis-100474379",false,"NCT05457140","Multiomic Diagnostics in Youth With Psychosis","Multiomic Diagnostics in Child and Adolescent Psychosis","Inclusion Criteria:\n\nIndividual in whom one of the following criteria is met:\n\n1. Child\u002Fadolescent admitted to the Rady Children's CAPS with symptoms of first break psychosis\n\n   OR\n2. Biological parents of child\u002Fadolescent enrolled in this study for the purposes of reflex testing. Family members are eligible for participation in this study if they are presumed genetically related to a patient participant.\n\nExclusion Criteria:\n\nChild\u002FAdolescent patients who do not meet any of the inclusion criteria, or those who:\n\n1. Already received any prior whole genome sequencing or exome sequencing.\n2. Unable to approach the family or patient for enrollment.\n3. Unable to obtain informed consent.\n4. Family members are ineligible for participation in this study if:\n\n   1. They are known to not be genetically related to the child\u002Fadolescent patient participant\n   2. They are a member of a protected research population","ALL","7 Years","17 Years",{"count":75,"type":76},15,"ESTIMATED","INTERVENTIONAL",[79],"NA","Rady Children's Institute for Genomic Medicine seeks to understand the genomes and immune systems in 15 children and adolescents who are admitted to Rady Children's Hospital Child and Adolescent Psychiatry Service with psychotic symptoms or schizophrenia. Cutting-edge genome and protein sequencing technology will be used to better understand how immunological and genetic assessments may improve our ability to identify the cause of psychosis and impact care. The investigator also hopes to identify new genetic and\u002For autoimmune causes of psychosis that may inform new treatment for future patients.",[82],"Psychosis",[84,85,86],"Genomic","Pediatric","Rady Children's Hospital","2024-11-12",{"date":89,"type":90},"2024-11-14","ACTUAL",{"date":92,"type":90},"2022-10-10",{"date":94,"type":76},"2026-08",{"name":5,"class":6},1]