[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100412997":3},{"organization":4,"armGroups":7,"interventions":17,"overallOfficials":40,"centralContacts":45,"locations":52,"responsibleParty":75,"collaborators":30,"id":77,"slug":78,"hasResults":79,"nctId":80,"briefTitle":81,"officialTitle":81,"acronym":82,"eligibilityCriteria":83,"healthyVolunteers":79,"sex":84,"minAge":85,"maxAge":30,"enrollmentInfo":86,"targetDuration":30,"studyType":89,"phases":90,"briefSummary":92,"conditions":93,"keywords":95,"overallStatus":99,"whyStopped":30,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":109},{"fullName":5,"class":6},"Centre Hospitalier Universitaire de Saint Etienne","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Myocardial revascularization cardiac surgery by coronary artery bypass grafting","EXPERIMENTAL","Patient with indication of Coronary Artery Bypass Grafting will be included. They will have:\n\n* before surgery : 4D cardiac MRI with gadoteric acid + ILR implantation + blood sampling\n* during surgery : right atrial biopsy\n* after surgery : Continuous monitoring by ILR for 12 months + scheduled clinical consultation (at 12 months)",[13,14,15,16],"Device: 4D cardiac MRI with gadoteric acid","Biological: Blood sample","Device: Implantable Loop Recorder (ILR)","Procedure: Right atrial biopsy",[18,25,31,35],{"type":19,"name":20,"description":21,"armGroupLabels":22,"otherNames":23},"DEVICE","4D cardiac MRI with gadoteric acid","4D cardiac MRI with gadoteric acid injection will be performed prior the surgery, according to a standardized technical protocol.",[9],[24],"4D flow Magnetic Resonance Imaging with Late Gadolinium Enhancement",{"type":26,"name":27,"description":28,"armGroupLabels":29,"otherNames":30},"BIOLOGICAL","Blood sample","Peripheral venous blood sample (1 x 6 ml EDTA tube): taken during preoperative assessment to measure inflammatory biomarkers (CRP, IL-1, TNF-α).",[9],null,{"type":19,"name":32,"description":33,"armGroupLabels":34,"otherNames":30},"Implantable Loop Recorder (ILR)","Implantation of a Holter monitor (Implantable Loop Recorder) prior to surgery, performed preoperatively under local anesthesia.\n\nThe ILR will enable continuous recording of the heart rhythm for 12 months with automatic data transmission via remote monitoring. The minimally invasive procedure will be performed by an experienced cardiologist under the usual safety conditions.",[9],{"type":36,"name":37,"description":38,"armGroupLabels":39,"otherNames":30},"PROCEDURE","Right atrial biopsy","During the surgical procedure (coronary artery bypass grafting), a right atrial biopsy will be performed using a brief, low-risk procedure on a small tissue sample. The sample will be analyzed using Masson's trichrome staining to assess atrial fibrosis.",[9],[41],{"name":42,"affiliation":43,"role":44},"Jean-Baptiste GUICHARD, MD","Hospital Clinic of Barcelona","STUDY_DIRECTOR",[46],{"name":47,"role":48,"phone":49,"phoneExt":50,"email":51},"Karim Benali, MD","CONTACT","(0)477828679","+33","karim.benali@chu-st-etienne.fr",[53],{"facility":54,"status":30,"city":55,"state":30,"zip":56,"country":57,"countryCode":58,"cosmosGeoPoint":59,"geoPoint":64,"contacts":65},"CHU Saint-Etienne","Saint-Etienne","42055","France","FR",{"type":60,"coordinates":61},"Point",[62,63],4.39,45.43389,{"lat":63,"lon":62},[66,68,70,72],{"name":67,"role":48,"phone":49,"phoneExt":50,"email":51},"Karim BENALI, MD",{"name":42,"role":48,"phone":30,"phoneExt":30,"email":69},"jbguichard@clinic.cat",{"name":67,"role":71,"phone":30,"phoneExt":30,"email":30},"PRINCIPAL_INVESTIGATOR",{"name":73,"role":74,"phone":30,"phoneExt":30,"email":30},"Antoine DA COSTA, MD, PhD","SUB_INVESTIGATOR",{"type":76,"investigatorFullName":30,"investigatorTitle":30,"investigatorAffiliation":30,"oldNameTitle":30,"oldOrganization":30},"SPONSOR","100412997","multiparametric-mri-assessment-of-atrial-heart-disease-as-a-predictor-of-atrial-fibrillation-after-myocardial-revascularization-surgery-100412997",false,"NCT04657835","Multiparametric MRI Assessment of Atrial Heart Disease as a Predictor of Atrial Fibrillation After Myocardial Revascularization Surgery","IRM-FAPO","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Indication for surgical myocardial revascularization by isolated coronary artery bypass grafting, to be performed in the cardiac surgery department of Saint-Étienne University Hospital.\n* Patient affiliated with or entitled to social security coverage\n* Patient who has received informed information about the study and has co-signed, with the investigator, a consent form to participate in the study\n\nExclusion Criteria:\n\n* Contraindication related to cardiac MRI\n* Contraindication related to ILR implantation\n* Documented history of atrial fibrillation\n* Concomitant indication for valve surgery or other associated cardiac intervention\n* Inability to understand French\n* Patient refusal to participate in the study and\u002For inability to express consent or sign the informed consent form\n* Patient subject to legal protection measures","ALL","18 Years",{"count":87,"type":88},100,"ESTIMATED","INTERVENTIONAL",[91],"NA","Postoperative atrial fibrillation (POAF) occurs in 20-40% of patients undergoing coronary artery bypass grafting (CABG) and is a marker of atrial vulnerability. It is strongly associated with AF recurrence, stroke, and cardiovascular mortality. It presents risk factors with atrial heart disease.\n\nThe latter refers to all structural, electrical, and mechanical alterations of the atrium that create a substrate conducive to AF.\n\nMultiparametric cardiac MRI is currently the most comprehensive test for assessing atrial heart disease, thanks to its structural and functional analysis (atrial fibrosis, atrial strain, intracavitary 4D flow). However, to date, no prospective study has evaluated these parameters as predictors of AF recurrence after CAP. At the same time, an implantable Holter monitor will be used to enable detailed and continuous detection of recurrence episodes, overcoming the limitations of conventional monitoring strategies. By combining multiparametric imaging, histological analysis, and continuous monitoring for the first time, this study proposes a paradigm shift in the assessment of postoperative AF: moving from a descriptive and ad hoc approach to a mechanistic, integrative, and predictive approach.",[94],"Postoperative Atrial Fibrillation",[96,97,98],"magnetic resonance imaging","implantable holter monitor","atrial heart disease","NOT_YET_RECRUITING","2026-03-03",{"date":102,"type":103},"2026-03-05","ACTUAL",{"date":105,"type":88},"2026-05-01",{"date":107,"type":88},"2028-12",{"name":5,"class":6},1]