[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100532265":3},{"organization":4,"armGroups":7,"interventions":21,"overallOfficials":31,"centralContacts":35,"locations":40,"responsibleParty":76,"collaborators":79,"id":82,"slug":83,"hasResults":84,"nctId":85,"briefTitle":86,"officialTitle":86,"acronym":87,"eligibilityCriteria":88,"healthyVolunteers":89,"sex":90,"minAge":91,"maxAge":92,"enrollmentInfo":93,"targetDuration":10,"studyType":96,"phases":10,"briefSummary":97,"conditions":98,"keywords":104,"overallStatus":43,"whyStopped":10,"lastUpdateSubmitDate":109,"lastUpdatePostDateStruct":110,"startDateStruct":113,"completionDateStruct":115,"leadSponsor":117,"locationsCount":118},{"fullName":5,"class":6},"Aalborg University Hospital","OTHER",[8,13,18],{"label":9,"type":10,"description":9,"interventionNames":11},"Living kidney donors",null,[12],"Procedure: Living kidney donation",{"label":14,"type":10,"description":15,"interventionNames":16},"Transplant recipients","Recipients of kidneys from living donors",[17],"Procedure: Renal transplantation",{"label":19,"type":10,"description":20,"interventionNames":10},"Healthy controls","Age- and sex matched healthy controls (Living kidney donors)",[22,27],{"type":23,"name":24,"description":25,"armGroupLabels":26,"otherNames":10},"PROCEDURE","Renal transplantation","Operative procedure - receipt of a kidney",[14],{"type":23,"name":28,"description":29,"armGroupLabels":30,"otherNames":10},"Living kidney donation","Operative procedure - donation of a kidney",[9],[32],{"name":33,"affiliation":5,"role":34},"Patrick Schjelderup, MD","PRINCIPAL_INVESTIGATOR",[36],{"name":33,"role":37,"phone":38,"phoneExt":10,"email":39},"CONTACT","+4597666015","pasc@rn.dk",[41,61],{"facility":42,"status":43,"city":44,"state":45,"zip":46,"country":47,"countryCode":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":55},"Department of Renal Medicine, Aarhus University Hospital","RECRUITING","Aarhus","Central Jutland","8200","Denmark","DK",{"type":50,"coordinates":51},"Point",[52,53],10.21076,56.15674,{"lat":53,"lon":52},[56,60],{"name":57,"role":37,"phone":58,"phoneExt":10,"email":59},"MD","+4578452455","karin.skov@auh.rm.dk",{"name":57,"role":34,"phone":10,"phoneExt":10,"email":10},{"facility":62,"status":43,"city":63,"state":64,"zip":65,"country":47,"countryCode":48,"cosmosGeoPoint":66,"geoPoint":70,"contacts":71},"Department of Nephrology, Aalborg University Hospital","Aalborg","North Denmark","9200",{"type":50,"coordinates":67},[68,69],9.9187,57.048,{"lat":69,"lon":68},[72,74],{"name":73,"role":37,"phone":38,"phoneExt":10,"email":39},"Patrick Schjelderup",{"name":75,"role":34,"phone":10,"phoneExt":10,"email":10},"Patrcik Schjelderup, MD",{"type":77,"investigatorFullName":73,"investigatorTitle":78,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"SPONSOR_INVESTIGATOR","Principal Investigator",[80],{"name":81,"class":6},"Aarhus University Hospital","100532265","multiparametric-mri-in-a-prospective-cohort-of-living-kidney-donors-recipients-and-healthy-controls-correlations-with-markers-of-renal-function-fibrosis-and-ageing-100532265",false,"NCT06210555","Multiparametric MRI in a Prospective Cohort of Living Kidney Donors, Recipients, and Healthy Controls: Correlations With Markers of Renal Function, Fibrosis and Ageing","MpRenal","Living kidney donors and transplant recipients:\n\nInclusion Criteria:\n\n* Approved as a living kidney donor or recipient of a kidney from a living donor.\n* Able to cooperate to an MRI examination\n\nExclusion Criteria:\n\n* Contraindications to MRI due to incompatible foreign objects.\n* Severe claustrophobia\n\nHealthy controls:\n\nInclusion Criteria:\n\n* Office BP \\\u003C 140\u002F90 mmHg. (use of 1 antihypertensive drug allowed)\n* Normal eGFR. (CKD-EPI)\n* Urine albumin-to-creatinine ratio \\\u003C 30 mg\u002Fg.\n* Dipstick negative for hematuria and proteinuria.\n* Able to cooperate to an MRI examination.\n\nExclusion Criteria:\n\n* Contraindications to MRI due to incompatible foreign objects.\n* Severe claustrophobia.\n* Pregnancy.\n* Condition(s) that would exclude living kidney donation.",true,"ALL","18 Years","80 Years",{"count":94,"type":95},96,"ESTIMATED","OBSERVATIONAL","Development of renal fibrosis is the irreversible culmination of various renal diseases and independently predicts adverse outcomes. Currently renal fibrosis can only be diagnosed by performing a renal biopsy. The procedure is invasive and is limited by sampling bias.\n\nIn recent years there has been a significant development in magnetic resonance imaging (MRI) based techniques. MRI can provide highly detailed anatomical images. Other MRI measures allow quantitative measurements of perfusion, oxygenation, tissue stiffness and diffusion of water molecules within tissue. The combination of several MRI techniques sensitive to different biophysical tissue properties in a single scan session is referred to as multiparametric MRI (mpMRI).\n\nEmerging evidence suggests that mpMRI could represent a method for indirect characterization of renal microstructure and extent of fibrosis. So far, studies performed in living kidney donors and recipients have been mostly cross-sectional. For mpMRI to transition to the clinical setting there is a need for validation of MRI-based measures with currently used reference methods for quantifying renal function and fibrosis.\n\nThe aim of this longitudinal observational study in a cohort of living kidney donors, recipients and healthy controls is to investigate the utility of repeated mpMRI over a period of 2 years. MRI-based measures will be compared to current reference methods for quantifying renal function and fibrosis.\n\nThe investigators hypothesize that there will be significant correlations between MRI-based measures, renal function determined by precise measurement of glomerular filtration rate and extent of fibrosis determined by renal biopsy. MRI-based measures are expected to be predictive of renal function decline and development of renal fibrosis.\n\nThis study could provide valuable data that will be helpful in moving the field of renal mpMRI forward, with the goal of providing a novel and non-invasive method for the diagnosis of renal pathology.",[99,100,101,102,103],"Kidney Transplantation","Multiparametric Magnetic Resonance Imaging","Living Donors","Renal Fibrosis","Senescence",[105,106,24,107,108],"MRI","Multiparametric","Fibrosis","Kidney donor","2025-07-23",{"date":111,"type":112},"2025-07-28","ACTUAL",{"date":114,"type":112},"2024-10-29",{"date":116,"type":95},"2029-08-01",{"name":73,"class":6},2]