[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100589620":3},{"organization":4,"armGroups":7,"interventions":78,"overallOfficials":101,"centralContacts":105,"locations":110,"responsibleParty":134,"collaborators":84,"id":137,"slug":138,"hasResults":139,"nctId":140,"briefTitle":141,"officialTitle":142,"acronym":143,"eligibilityCriteria":144,"healthyVolunteers":139,"sex":145,"minAge":146,"maxAge":147,"enrollmentInfo":148,"targetDuration":84,"studyType":151,"phases":152,"briefSummary":154,"conditions":155,"keywords":159,"overallStatus":113,"whyStopped":84,"lastUpdateSubmitDate":162,"lastUpdatePostDateStruct":163,"startDateStruct":166,"completionDateStruct":168,"leadSponsor":170,"locationsCount":171},{"fullName":5,"class":6},"University of Rochester","OTHER",[8,17,22,26,30,34,38,42,46,50,54,58,62,66,70,74],{"label":9,"type":10,"description":11,"interventionNames":12},"Treatment Condition 1","EXPERIMENTAL","Participants receive emotion regulation, exposure, cognitive processing, and bi-lateral stimulation",[13,14,15,16],"Behavioral: Emotion Regulation","Behavioral: Exposure","Behavioral: Cognitive Processing","Behavioral: Bi-lateral Stimulation",{"label":18,"type":10,"description":19,"interventionNames":20},"Treatment Condition 2","Participants receive emotion regulation, exposure, cognitive processing, and psychological placebo",[13,14,15,21],"Behavioral: Psychological Placebo",{"label":23,"type":10,"description":24,"interventionNames":25},"Treatment Condition 3","Participants receive emotion regulation, exposure, bi-lateral stimulation, and psychological placebo",[13,14,16,21],{"label":27,"type":10,"description":28,"interventionNames":29},"Treatment Condition 4","Participants receive emotion regulation, exposure, and psychological placebo",[13,14,21],{"label":31,"type":10,"description":32,"interventionNames":33},"Treatment Condition 5","Participants receive emotion regulation, cognitive processing, bi-lateral stimulation, and psychological placebo",[13,15,16,21],{"label":35,"type":10,"description":36,"interventionNames":37},"Treatment Condition 6","Participants receive emotion regulation, cognitive processing, and psychological placebo",[13,15,21],{"label":39,"type":10,"description":40,"interventionNames":41},"Treatment Condition 7","Participants receive emotion regulation, bi-lateral stimulation, and psychological placebo",[13,16,21],{"label":43,"type":10,"description":44,"interventionNames":45},"Treatment Condition 8","Participants receive emotion regulation and psychological placebo",[13,21],{"label":47,"type":10,"description":48,"interventionNames":49},"Treatment Condition 9","Participants receive exposure, cognitive processing, bi-lateral stimulation, and psychological placebo",[14,15,16,21],{"label":51,"type":10,"description":52,"interventionNames":53},"Treatment Condition 10","Participants receive exposure, cognitive processing, and psychological placebo",[14,15,21],{"label":55,"type":10,"description":56,"interventionNames":57},"Treatment Condition 11","Participants receive exposure, bi-lateral stimulation, and psychological placebo",[14,16,21],{"label":59,"type":10,"description":60,"interventionNames":61},"Treatment Condition 12","Participants receive exposure and psychological placebo",[14,21],{"label":63,"type":10,"description":64,"interventionNames":65},"Treatment Condition 13","Participants receive cognitive processing, bi-lateral stimulation, and psychological placebo",[15,16,21],{"label":67,"type":10,"description":68,"interventionNames":69},"Treatment Condition 14","Participants receive cognitive processing and psychological placebo",[15,21],{"label":71,"type":10,"description":72,"interventionNames":73},"Treatment Condition 15","Participants receive bi-lateral stimulation and psychological placebo",[16,21],{"label":75,"type":10,"description":76,"interventionNames":77},"Treatment Condition 16","Participants receive psychological placebo",[21],[79,85,89,93,97],{"type":80,"name":81,"description":82,"armGroupLabels":83,"otherNames":84},"BEHAVIORAL","Emotion Regulation","Participants learn to reduce acute subjective distress, stabilize negative mood, promote positive mood, and alter physiological responses to trauma",[9,18,23,27,31,35,39,43],null,{"type":80,"name":86,"description":87,"armGroupLabels":88,"otherNames":84},"Exposure","Participants engage in written exercises to reduce avoidance of trauma reminders and reinforce approach behaviors consistent with personal goals",[9,51,55,59,18,23,27,47],{"type":80,"name":90,"description":91,"armGroupLabels":92,"otherNames":84},"Cognitive Processing","Participants learn ways to identify, challenge, and overcome the influence of cognitive distortions resulting from trauma exposure",[9,51,63,67,18,31,35,47],{"type":80,"name":94,"description":95,"armGroupLabels":96,"otherNames":84},"Bi-lateral Stimulation","Participants engage in horizontal eye movements while recalling a traumatic memory and describing their affective and physiological state",[9,55,63,71,23,31,39,47],{"type":80,"name":98,"description":99,"armGroupLabels":100,"otherNames":84},"Psychological Placebo","Participants receive non-directive support therapy, where they will guide the treatment session but not be required to discuss prior trauma exposure",[51,55,59,63,67,71,75,18,23,27,31,35,39,43,47],[102],{"name":103,"affiliation":5,"role":104},"Chad E Shenk, PhD","PRINCIPAL_INVESTIGATOR",[106],{"name":103,"role":107,"phone":108,"phoneExt":84,"email":109},"CONTACT","(585) 275-8704","chad.shenk@rochester.edu",[111],{"facility":112,"status":113,"city":114,"state":115,"zip":116,"country":117,"countryCode":118,"cosmosGeoPoint":119,"geoPoint":124,"contacts":125},"The Mt. Hope Family Center","RECRUITING","Rochester","New York","14608","United States","US",{"type":120,"coordinates":121},"Point",[122,123],-77.61556,43.15478,{"lat":123,"lon":122},[126,130,133],{"name":127,"role":107,"phone":128,"phoneExt":84,"email":129},"Haley Trehern, BS","585-481-7609","haley_trehern@urmc.rochester.edu",{"name":131,"role":107,"phone":132,"phoneExt":84,"email":109},"Chad Shenk, PhD","585-273-3264",{"name":131,"role":104,"phone":84,"phoneExt":84,"email":84},{"type":104,"investigatorFullName":135,"investigatorTitle":136,"investigatorAffiliation":5,"oldNameTitle":84,"oldOrganization":84},"Chad Shenk","Professor of Psychology","100589620","multiphase-optimization-strategy-most-for-treating-pediatric-post-traumatic-stress-disorder-ptsd-100589620",false,"NCT06956781","Multiphase Optimization Strategy (MOST) for Treating Pediatric Post-traumatic Stress Disorder (PTSD)","Optimizing Behavioral Health Services Following Pediatric Trauma Exposure","MOST for PTSD","Inclusion Criteria:\n\nA child between the ages of 8-17 exposed to at least one DSM-defined trauma\n\nChild assent for participation\n\nThe participation of a caregiver with custodial rights to provide parental permission\n\nWilling to participate in treatment delivery and respond to surveys\n\nMeet PTSD diagnostic criteria that is the result of exposure to at least one of the identified traumas\n\nAbility to read and understand English\n\nWillingness to be randomized to an experimental condition\n\nPlacement in a stable caregiving environment for two months without an impending transition\n\nChildren currently taking psychotropic medications must have taken the medicine without dose adjustment for two months prior to study entry.\n\nCaregiver or child with a smartphone capable of downloading a freely available software application.\n\nExclusion Criteria:\n\nPsychiatric concerns requiring a higher level of care (e.g. suicidal ideation with intent; current psychotic disorder)\n\nAn intelligence quotient (IQ) \\\u003C 70\n\nCurrently receiving a behavioral health intervention for concerns related to PTSD or pediatric trauma\n\nA participating caregiver who is a perpetrator of any identified trauma (e.g. sexual abuse)\n\nMRI contraindicators (e.g. presence of metal in the body)","ALL","8 Years","17 Years",{"count":149,"type":150},200,"ESTIMATED","INTERVENTIONAL",[153],"NA","The goal of this clinical trial is to test the extent to which different treatment components work to improve pediatric post-traumatic stress disorder (PTSD). It will also provide evidence for how these components work. The main research questions are:\n\nWhat are the effects of different components used to treat PTSD? What do these components change to produce benefits in PTSD?\n\nResearchers will:\n\nCompare components to a psychological placebo to estimate their effects and measure how they work\n\nExamine how components work alone and in conjunction with other components\n\nParticipants will:\n\nReceive different combinations of components and placebo\n\nAttend weekly treatment sessions\n\nProvide information to evaluate changes in PTSD",[156,157,158],"PTSD","Trauma","Pediatric ALL",[156,157,160,161],"Pediatric","Multiphase Optimization Strategy","2026-04-07",{"date":164,"type":165},"2026-04-08","ACTUAL",{"date":167,"type":165},"2026-03-15",{"date":169,"type":150},"2028-08",{"name":5,"class":6},1]