[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100630907":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":29,"centralContacts":33,"locations":43,"responsibleParty":63,"collaborators":67,"id":70,"slug":71,"hasResults":72,"nctId":73,"briefTitle":74,"officialTitle":74,"acronym":75,"eligibilityCriteria":76,"healthyVolunteers":77,"sex":78,"minAge":79,"maxAge":80,"enrollmentInfo":81,"targetDuration":29,"studyType":84,"phases":85,"briefSummary":87,"conditions":88,"keywords":90,"overallStatus":92,"whyStopped":29,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":102},{"fullName":5,"class":6},"Harvard School of Public Health (HSPH)","OTHER",[8,15,20],{"label":9,"type":10,"description":11,"interventionNames":12},"Arm I: Control","ACTIVE_COMPARATOR","Participants in the control arm receive the core package without additional digital interventions. This includes:\n\n* A brief, in-person information session on adolescent nutrition, anemia, and the use and importance of multiple micronutrient supplements (MMS).\n* A set of printed nutrition education brochures covering adolescent nutrition, anemia prevention, MMS use, and where to seek care.\n* A 2-month supply of MMS tablets in bottles, with instructions for daily consumption and written guidance on when and where to obtain refills, as well as contact information for reporting any side effects.\n\nControl arm participants do not receive weekly SMS messages or the fortnightly in-person digital group nutrition sessions.",[13,14],"Behavioral: Behavioral: SMS Intervention (Intervention Arm I)","Behavioral: Behavioral: In Person Digital Arm (Intervention Arm II)",{"label":16,"type":17,"description":18,"interventionNames":19},"Behavioral: SMS Intervention (Intervention Arm I)","EXPERIMENTAL","Participants in the SMS arm receive the same core package as the control group plus a low intensity digital intervention: Core package (as in Control): One time in person information session on adolescent nutrition, anemia, and correct use of multiple micronutrient supplements (MMS). Printed nutrition education brochures. A 2 month supply of daily MMS tablets, with instructions and access to bimonthly refills. Digital component (Strategy I): Weekly one way SMS messages sent to a phone number provided at enrollment (adolescent's own or a household\u002Fshared phone). Messages reinforce key nutrition and anemia information, remind adolescents to take MMS daily, and prompt them to obtain MMS refills on time. Content is age appropriate and gender sensitive but maintains consistent core messages for all participants. No fortnightly in person digital group sessions are provided in this arm.",[13],{"label":21,"type":17,"description":22,"interventionNames":23},"Behavioral: In Person Digital Arm (Intervention Arm II)","Participants in the in person digital arm receive the full intervention package: Core package (as in Control): - One time in person information session on adolescent nutrition, anemia, and correct use of MMS. - Printed nutrition education brochures. - A 2 month supply of daily MMS tablets, with instructions and access to bimonthly refills. Digital Strategy I (as in SMS Arm): - Weekly one way SMS messages reinforcing nutrition and anemia messages and reminding adolescents to take MMS and obtain refills. Digital Strategy II (additional in person digital component): - Fortnightly, 1 hour in person digital group nutrition education sessions held in school computer labs or similar settings, facilitated by trained teacher assistants or peer support workers. - Sessions use audio visual and interactive digital content (e.g., animations, quizzes, games) to teach nutrition and anemia related topics. - Adolescents co-create and share digital nutrition content",[14],[25,30],{"type":26,"name":16,"description":27,"armGroupLabels":28,"otherNames":29},"BEHAVIORAL","Participants in the SMS arm receive the same core package as the control group plus a low intensity digital intervention: Core package (as in Control): One time in person information session on adolescent nutrition, anemia, and correct use of multiple micronutrient supplements (MMS). Printed nutrition education brochures. A 2 month supply of daily MMS tablets, with instructions and access to bimonthly refills. Digital component (Strategy I): Weekly one way SMS\u002FWhatsApp messages sent to a phone number provided at enrollment (adolescent's own or a household\u002Fshared phone). Messages reinforce key nutrition and anemia information, remind adolescents to take MMS daily, and prompt them to obtain MMS refills on time. Content is age appropriate and gender sensitive but maintains consistent core messages for all participants. No fortnightly in person digital group sessions are provided in this arm.",[9,16],null,{"type":26,"name":21,"description":31,"armGroupLabels":32,"otherNames":29},"Participants in the in person digital arm receive the full intervention package: Core package (as in Control): - One time in person information session on adolescent nutrition, anemia, and correct use of MMS. - Printed nutrition education brochures. - A 2 month supply of daily MMS tablets, with instructions and access to bimonthly refills. Digital Strategy I (as in SMS Arm): - Weekly one way SMS messages reinforcing nutrition and anemia messages and reminding adolescents to take MMS and obtain refills. Digital Strategy II (additional in person digital component): - Fortnightly, 1 hour in person digital group nutrition education sessions held in school computer labs or similar settings, facilitated by trained teacher assistants or peer support workers. - Sessions use audio visual and interactive digital content (e.g., animations, quizzes, games) to teach nutrition and anemia related topics. - Adolescents co-create and disseminate digital nutrition content",[9,21],[34,39],{"name":35,"role":36,"phone":37,"phoneExt":29,"email":38},"Wafaie Fawzi, MD, DrPH, MPH","CONTACT","+16178181864","mina@hsph.harvard.edu",{"name":40,"role":36,"phone":41,"phoneExt":29,"email":42},"Sachin Shinde, PhD, MPA, MA","+16174351445","sshinde@hsph.harvard.edu",[44],{"facility":45,"status":29,"city":46,"state":29,"zip":29,"country":47,"countryCode":29,"cosmosGeoPoint":48,"geoPoint":53,"contacts":54},"Dar Health and Demographic Surveillance System Area","Dar es Salaam","Tanzania",{"type":49,"coordinates":50},"Point",[51,52],39.26951,-6.82349,{"lat":52,"lon":51},[55,59],{"name":56,"role":36,"phone":57,"phoneExt":29,"email":58},"Mary Mawanyika-Sando, MD, MPH","+255713269063","msando@aaph.or.tz",{"name":60,"role":36,"phone":61,"phoneExt":29,"email":62},"Alison Kabanda, PhD","+255620407037","akabanda@aaph.or.tz",{"type":64,"investigatorFullName":65,"investigatorTitle":66,"investigatorAffiliation":5,"oldNameTitle":29,"oldOrganization":29},"PRINCIPAL_INVESTIGATOR","Wafaie Fawzi","Professor",[68],{"name":69,"class":6},"Africa Academy for Public Health","100630907","multiple-micronutrient-supplementation-with-digital-layering-among-adolescents-in-tanzania-100630907",false,"NCT07493772","Multiple Micronutrient Supplementation With Digital Layering Among Adolescents in Tanzania","MMSDigitalTZ","Inclusion Criteria:\n\n* Aged 15-19 years at enrollment.\n* Resident in the Dar es Salaam HDSS coverage area.\n* Has access to at least one phone (own or shared within the household; feature phone or smartphone).\n* Demonstrates basic literacy skills sufficient to understand simple written messages.\n* Has capacity to provide informed consent (for those ≥18 years) or assent (for those \\\u003C18 years, with parental\u002Fguardian consent).\n\nExclusion Criteria:\n\n* Currently pregnant.\n* Enrolled in the ARISE-NUTRINT trial.\n* Currently taking iron and folic acid or multiple micronutrient tablets for anemia outside this study.\n* Known to have HIV infection at the time of screening.\n* More than one eligible adolescent per household: if multiple adolescents meet criteria in a household, one will be randomly selected to participate.",true,"ALL","15 Years","19 Years",{"count":82,"type":83},1200,"ESTIMATED","INTERVENTIONAL",[86],"NA","This study is a three-arm, individually randomized controlled trial evaluating the impact of digitally delivered nutrition education, layered onto multiple micronutrient supplementation (MMS), on anemia and related health behaviors among adolescents in Dar es Salaam, Tanzania. A total of 1,200 adolescents aged 15-19 years with access to a phone (own or shared) will be enrolled from the Dar es Salaam Health and Demographic Surveillance System and followed for 9 months, with assessments at baseline, 4 months, and 9 months.\n\nAll participants will receive a brief in-person nutrition education session, printed brochures on adolescent nutrition and anemia, and a 2-month supply of daily MMS tablets with instructions and access to refills (Control arm). In Intervention Arm I, participants will receive the same package plus weekly one-way SMS\u002FWhatsApp messages reinforcing key nutrition content and adherence to MMS and refills. In Intervention Arm II, participants will receive all components of Arm I plus fortnightly, in-person group digital nutrition education sessions that include interactive content and opportunities to co-create and share digital nutrition messages with peers. All participants will receive information on replenishing the tablets. Participants in Intervention Arm I and Intervention Arm II will receive additional nutrition, diet, and physical activity-related messages along with reminders and motivational encouragement to replenish their supplement stocks.\n\nThe primary outcome is anemia prevalence, assessed using hemoglobin concentration and WHO age- and sex-specific cutoffs. Secondary outcomes include moderate\u002Fsevere anemia, hemoglobin levels, adherence to MMS pick-up and consumption, nutrition literacy, dietary diversity, fruit and vegetable intake, physical activity, underweight\u002Foverweight\u002Fobesity, and digital literacy. The trial also includes a mixed-methods process evaluation of feasibility, acceptability, reach, engagement with the digital components, and a cost estimation of the digital strategies.",[89],"Anemia",[91],"Adolescents, multiple micronutrient supplements, RCT, Tanzania","NOT_YET_RECRUITING","2026-03-20",{"date":95,"type":96},"2026-03-25","ACTUAL",{"date":98,"type":83},"2026-05-01",{"date":100,"type":83},"2027-03-31",{"name":5,"class":6},1]