[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100544061":3},{"organization":4,"armGroups":7,"interventions":26,"overallOfficials":40,"centralContacts":45,"locations":54,"responsibleParty":72,"collaborators":76,"id":79,"slug":80,"hasResults":81,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":32,"eligibilityCriteria":85,"healthyVolunteers":81,"sex":86,"minAge":87,"maxAge":88,"enrollmentInfo":89,"targetDuration":32,"studyType":92,"phases":93,"briefSummary":95,"conditions":96,"keywords":99,"overallStatus":56,"whyStopped":32,"lastUpdateSubmitDate":107,"lastUpdatePostDateStruct":108,"startDateStruct":111,"completionDateStruct":113,"leadSponsor":115,"locationsCount":116},{"fullName":5,"class":6},"Jagiellonian University","OTHER",[8,14,20],{"label":9,"type":10,"description":11,"interventionNames":12},"rTMS over the left DLPFC and over the left DMPFC","EXPERIMENTAL","Active 10 Herz rTMS with intensity of 120% of the resting motor threshold recorded from the right first dorsal interosseus and the right abductor hallucis will be administered over the left DLPFC and over the left DMPFC respectively. Therapy will include 20 sessions (one session in each of 20 consecutive working days - four weeks in total). In every session ca 1500 magnetic pulses over the left DLPFC and ca 1500 over the left DMPFC will be elicited.",[13],"Device: Active rTMS over the left DLPFC and over the left DMPFC",{"label":15,"type":16,"description":17,"interventionNames":18},"rTMS over the left DLPFC","ACTIVE_COMPARATOR","Active 10 Herz rTMS with intensity of 120% of the resting motor threshold recorded from the right first dorsal interosseus will be administered over the left DLPFC. Therapy will include 20 sessions (one session in each of 20 consecutive working days - four weeks in total). In every session 3000 magnetic pulses over the left DLPFC will be elicited.",[19],"Device: Active rTMS over the left DLPFC",{"label":21,"type":22,"description":23,"interventionNames":24},"Sham rTMS","SHAM_COMPARATOR","Sham 10 Herz rTMS will be administered over the left DLPFC. Therapy will include 20 sessions (one session in each of 20 consecutive working days - four weeks in total). In every session 3000 magnetic pulses over the left DLPFC or ca 1500 magnetic pulses over the left DLPFC and ca 1500 over the left DMPFC will be elicited. (rTMS protocol will be chosen randomly before the first session).",[25],"Device: Sham rTMS",[27,33,37],{"type":28,"name":29,"description":30,"armGroupLabels":31,"otherNames":32},"DEVICE","Active rTMS over the left DLPFC and over the left DMPFC","Active rTMS over the left DLPFC and over the left DMPFC to induce the long term potentiation of stimulated areas.",[9],null,{"type":28,"name":34,"description":35,"armGroupLabels":36,"otherNames":32},"Active rTMS over the left DLPFC","Active rTMS over the left DLPFC to induce the long term potentiation of stimulated area.",[15],{"type":28,"name":21,"description":38,"armGroupLabels":39,"otherNames":32},"Sham rTMS over the left DLPFC or over the left DLPFC and over the left DMPFC for placebo.",[21],[41],{"name":42,"affiliation":43,"role":44},"Wojciech Korzeniowski, MD","The Education of Research and Development Center, Babinski Clinical Hospital","PRINCIPAL_INVESTIGATOR",[46,50],{"name":42,"role":47,"phone":48,"phoneExt":32,"email":49},"CONTACT","+48 12 652 45 20","wojciech.korzen@gmail.com",{"name":51,"role":47,"phone":52,"phoneExt":32,"email":53},"Jakub Antczak, MD","+48 12 400 25 50","jakub.antczak@uj.edu.pl",[55],{"facility":43,"status":56,"city":57,"state":32,"zip":58,"country":59,"countryCode":60,"cosmosGeoPoint":61,"geoPoint":66,"contacts":67},"RECRUITING","Krakow","30393","Poland","PL",{"type":62,"coordinates":63},"Point",[64,65],19.93658,50.06143,{"lat":65,"lon":64},[68,70],{"name":42,"role":47,"phone":69,"phoneExt":32,"email":49},"+48 12 652 42 00",{"name":51,"role":47,"phone":71,"phoneExt":32,"email":53},"+48 12 25 50",{"type":73,"investigatorFullName":74,"investigatorTitle":75,"investigatorAffiliation":5,"oldNameTitle":32,"oldOrganization":32},"SPONSOR_INVESTIGATOR","Jakub Antczak","Clinical Professor",[77],{"name":78,"class":6},"Andrzej Frycz Modrzewski Krakow University","100544061","multisite-rtms-for-mood-cognitive-impairment-and-other-symptoms-of-depression-100544061",false,"NCT06363981","Multisite rTMS for Mood, Cognitive Impairment and Other Symptoms of Depression","Multisite Repetitive Transcranial Magnetic Stimulation for Mood, Cognitive Impairment, Anhedonia and Disordered Sleep in Depressive Disorder","Inclusion Criteria:\n\n* severe or moderate depressive episode (according to international classification of diseases (ICD)-10) without psychotic symptoms at the time of inclusion\n* Hamilton Depression Rating Scale between between 20 and 35 points at inclusion\n* The score in the Athens Insomnia Scale eight or more\n* The score of three or more points in items 4 and 21 of the Beck Depressions Inventory 2\n* Complaining about problems with memory and concentration timely related with the onset of depression\n\nExclusion Criteria:\n\n* Contraindications to transcranial magnetic stimulation, including ferromagnetic elements in head, pregnancy and epilepsy\n* Psychotic symptoms at the time of inclusion\n* Suicidal ideations and\u002For attempts within three months prior to inclusion","ALL","18 Years","65 Years",{"count":90,"type":91},90,"ESTIMATED","INTERVENTIONAL",[94],"NA","Depressed mood is the main symptom of depression, but other symptoms like cognitive impairment, anhedonia or sleep disorders may also contribute to patients suffering and are difficult to treat. rTMS is a relatively novel treatment option, whose therapeutic potential is still investigated and optimized. The aim of this study is to assess the effect of rTMS applied over two stimulation sites on cognitive impairment, anhedonia and sleep disorders in depression.",[97,98],"Unipolar Depression","Bipolar Disorder",[100,101,102,103,104,105,106],"depression","repetitive transcranial magnetic stimulation","dorsolateral prefrontal cortex","dorsomedial prefrontal cortex","cognitive impairment","anhedonia","sleep disorders","2024-10-09",{"date":109,"type":110},"2024-10-15","ACTUAL",{"date":112,"type":110},"2024-05-20",{"date":114,"type":91},"2027-04",{"name":74,"class":6},1]