[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100594620":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":24,"centralContacts":29,"locations":35,"responsibleParty":54,"collaborators":10,"id":58,"slug":59,"hasResults":60,"nctId":61,"briefTitle":62,"officialTitle":62,"acronym":63,"eligibilityCriteria":64,"healthyVolunteers":65,"sex":66,"minAge":67,"maxAge":10,"enrollmentInfo":68,"targetDuration":10,"studyType":71,"phases":10,"briefSummary":72,"conditions":73,"keywords":75,"overallStatus":38,"whyStopped":10,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":86},{"fullName":5,"class":6},"University of Erlangen-Nürnberg Medical School","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"CNM",null,"patients with diagnosed centronuclear myopathy",[13],"Diagnostic Test: MSOT",{"label":15,"type":10,"description":16,"interventionNames":17},"HV","Healthy control",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":10},"DIAGNOSTIC_TEST","MSOT","Multispectral optoacoustic tomography (MSOT) enables the detection of specific endogenous chromophores such as collagen, myoglobin or haemoglobin using a non-invasive approach comparable to conventional ultrasound. Instead of sound waves, MSOT illuminates the tissue with near-infrared light of transient energy, which is absorbed and leads to thermoelastic expansion of certain molecules. This expansion generates ultrasound waves that are detected by the same device. The multispectral illumination and unmixing then enable the precise localization and quantification of muscle-specific subcellular structures. MSOT has already shown the potential to visualize the muscle structure and clinical extent of muscle disease in patients with Duchenne muscular dystrophy, spinal muscular atrophy and the late-onset Pompe disease (LOPD) and to distinguish these patients from healthy volunteers. To date, there is no optoacoustic data on CNM.",[9,15],[25],{"name":26,"affiliation":27,"role":28},"Ferdinand Knieling, PD Dr. med. habil. Dr. rer. b","Kinder- & Jugendklinik, Erlangen","STUDY_CHAIR",[30],{"name":31,"role":32,"phone":33,"phoneExt":10,"email":34},"Lina Tan","CONTACT","+49 9131 85-41277","Lina.Tan@uk-erlangen.de",[36],{"facility":37,"status":38,"city":39,"state":40,"zip":41,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"Uniklinikum Erlangen","RECRUITING","Erlangen","Bavaria","91054","Germany","DE",{"type":45,"coordinates":46},"Point",[47,48],11.00783,49.59099,{"lat":48,"lon":47},[51],{"name":26,"role":32,"phone":52,"phoneExt":10,"email":53},"09131-8541337","ferdinand.knieling@uk-erlangen.de",{"type":55,"investigatorFullName":56,"investigatorTitle":57,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Ferdinand Knieling","Study Chair","100594620","multispectral-optoacoustic-tomography-for-advanced-imaging-of-centronuclear-myopathy-100594620",false,"NCT07021820","Multispectral Optoacoustic Tomography for Advanced Imaging of Centronuclear Myopathy","MOSAIC","CNM arm:\n\nInclusion Criteria: diagnosed CNM; minimum of 2 years of age\n\nExclusion Criteria:\n\n* Pregnancy\n* Nursing mothers\n* Tattoo in the area of the examination field\n* Subcutaneous fatty tissue \\> 3 cm\n\nHV:\n\nInclusion criteria: minimum of 2 years of age\n\nExclusion criteria:\n\n* any signs\u002Fhistory of muscle diseases\n* Pregnancy\n* Nursing mothers\n* Tattoo in the area of the examination field\n* Subcutaneous fatty tissue \\> 3 cm",true,"ALL","2 Years",{"count":69,"type":70},40,"ESTIMATED","OBSERVATIONAL","Twenty patients with centronuclear myopathy and twenty age- and sex-matched, muscle-healthy controls will undergo diagnostic examination. Study participants will undergo physical examination, clinical and functional testing, and multispectral optoacoustic tomography (MSOT) scanning at predefined muscle sites (paraspinal muscles, trapezius muscle, deltoid muscle, forearm flexors, quadriceps muscle, adductor muscles, ischiocrural muscles, triceps surae muscle, and tibialis anterior).",[74],"Centronuclear Myopathy",[21,76,63],"centronuclear myopathy","2025-06-11",{"date":79,"type":80},"2025-06-15","ACTUAL",{"date":82,"type":80},"2025-05-29",{"date":84,"type":70},"2026-12-31",{"name":5,"class":6},1]