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Have anatomically severe multi-vessel coronary artery disease\n3. Have physiological evidence of myocardial ischaemia",[13,14],"Procedure: Percutaneous coronary intervention (PCI)","Diagnostic Test: Symptom assessment during experimentally induced ischaemia",[16,22],{"type":17,"name":18,"description":19,"armGroupLabels":20,"otherNames":21},"PROCEDURE","Percutaneous coronary intervention (PCI)","Coronary artery stenting for stable angina",[9],null,{"type":23,"name":24,"description":25,"armGroupLabels":26,"otherNames":21},"DIAGNOSTIC_TEST","Symptom assessment during experimentally induced ischaemia","Transient experimental balloon occlusion across coronary stenosis to determine the symptoms conferred by ischaemia at this stenosis.",[9],[28],{"name":29,"affiliation":5,"role":30},"Rasha Al-Lamee, PhD MRCP","PRINCIPAL_INVESTIGATOR",[32,37],{"name":33,"role":34,"phone":35,"phoneExt":21,"email":36},"Shayna Chotai, MBBS 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7222","nick.curzen@uhs.nhs.uk",{"type":155,"investigatorFullName":21,"investigatorTitle":21,"investigatorAffiliation":21,"oldNameTitle":21,"oldOrganization":21},"SPONSOR",[157,160,162,164,166],{"name":158,"class":159},"Royal Bournemouth and Christchurch Hospitals NHS Foundation Trust","OTHER_GOV",{"name":161,"class":6},"Mid and South Essex NHS Foundation Trust",{"name":163,"class":6},"Imperial College Healthcare NHS Trust",{"name":165,"class":6},"St George's Healthcare NHS Trust",{"name":167,"class":6},"Royal Free Hospital NHS Foundation Trust","100546847","multivessel-balloon-occlusion-to-investigate-obstructive-coronary-artery-disease-and-angina-100546847",false,"NCT06400290","Multivessel Balloon Occlusion to Investigate Obstructive Coronary Artery Disease and aNgina","ORBITA-MOON","Inclusion Criteria:\n\n* Eligibility for PCI due to angina\n* Anatomical evidence of significant multi-vessel coronary stenosis defined by either:\n\n  1. ≥70% stenosis in two or more coronary arteries of ≥2.5mm visual diameter stenosis, on invasive coronary angiography (ICA)\n  2. Severe stenosis in ≥2 coronary arteries of ≥ 2.5mm visual diameter stenosis, on CTCA\n* Physiological evidence of ischaemia with a positive test corresponding to the coronary arteries to be stented, on at least one of the following:\n\n  * dobutamine stress echocardiogram\n  * cardiac MRI\n  * myocardial perfusion study\n  * invasive metrics of coronary physiology\n\nExclusion Criteria:\n\n* Recent acute coronary syndrome\n* Previous coronary artery by-pass graft surgery (CABG)\n* Significant left main stem disease\n* Chronic total occlusion in the target artery(s)\n* Moderate to severe valvular disease\n* Moderate to severe left ventricular impairment\n* Contraindication to PCI or a drug-eluting stents\n* Contraindication to antiplatelet therapy\n* Contraindication to adenosine\n* Pregnant\n* Inability to consent","ALL","18 Years",{"count":178,"type":179},60,"ESTIMATED","INTERVENTIONAL",[182],"NA","ORBITA-MOON is a double-blinded, placebo-controlled experimental study that aims to understand how the different coronary artery stenoses contribute to overall clinical angina in patients with multi-vessel coronary artery disease. This study will investigate the symptoms conferred by each stenosis, induced by experimental ischaemia, for 60 patients with multi-vessel coronary artery disease.",[185,186],"Stable Angina","Multivessel Coronary Artery Disease",[188,189,190,191],"Angina","Multi-vessel coronary artery disease","Symptoms","Placebo-controlled symptom assessment","2025-06-05",{"date":194,"type":195},"2025-06-06","ACTUAL",{"date":197,"type":195},"2024-06-13",{"date":199,"type":179},"2027-04",{"name":5,"class":6},9]