[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100617093":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":30,"centralContacts":40,"locations":48,"responsibleParty":80,"collaborators":83,"id":87,"slug":88,"hasResults":89,"nctId":90,"briefTitle":91,"officialTitle":92,"acronym":93,"eligibilityCriteria":94,"healthyVolunteers":95,"sex":96,"minAge":97,"maxAge":98,"enrollmentInfo":99,"targetDuration":25,"studyType":102,"phases":103,"briefSummary":105,"conditions":106,"keywords":111,"overallStatus":117,"whyStopped":25,"lastUpdateSubmitDate":118,"lastUpdatePostDateStruct":119,"startDateStruct":122,"completionDateStruct":124,"leadSponsor":126,"locationsCount":127},{"fullName":5,"class":6},"Catharina Ziekenhuis Eindhoven","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Multivessel hybrid coronary revascularization (HCR)","ACTIVE_COMPARATOR","Minimally invasive coronary artery bypass surgery to the left sided coronary vessels combined with percutaneous coronary intervention to the right coronary artery.",[13],"Procedure: Multivessel Hybrid Coronary Revascularization",{"label":15,"type":10,"description":16,"interventionNames":17},"Off-pump coronary artery bypass grafting (OPCAB)","Total arterial, anaortic off-pump ccoronary artery bypass grafting through median sternotomy.",[18],"Procedure: Off-pump coronary arterial bypass grafting (OPCAB)",[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"PROCEDURE","Multivessel Hybrid Coronary Revascularization","Multivessel-HCR consists of MICS revascularization of the left sided coronary vessels (LAD , Cx) combined with PCI for the RCA during the same admission or within 4 weeks postoperatively. Surgical revascularization is performed through MICS which consists of either robotically or non-robotically assisted thoracoscopic IMA harvesting followed by total arterial off-pump anastomosis of the grafts through a left anterior 3-5 cm mini-thoracotomy. PCI will be performed via radial or femoral access according to local routine and is restricted to the RCA.",[9],null,{"type":21,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Off-pump coronary arterial bypass grafting (OPCAB)","OPCAB will be performed as per clinical routine at each center through a median sternotomy. IMA harvesting (pedicled or skeletonised) follows each center's routine. An anaortic, total arterial strategy with a LIMA-LAD graft and complete revascularisation is obliged.",[15],[31,34,38],{"name":32,"affiliation":5,"role":33},"Ferdi Akca, MD, PhD","PRINCIPAL_INVESTIGATOR",{"name":35,"affiliation":36,"role":37},"Wouter Oosterlinck, Prof. Dr. MD, PhD","Universitaire Ziekenhuizen KU Leuven","STUDY_CHAIR",{"name":39,"affiliation":5,"role":37},"Pim Tonino, Prof. Dr. MD, PhD",[41,45],{"name":32,"role":42,"phone":43,"phoneExt":25,"email":44},"CONTACT","+31 40 239 9111","ferdi.akca@catharinaziekenhuis.nl",{"name":46,"role":42,"phone":43,"phoneExt":25,"email":47},"Ismail Cenik, MD","ismail.cenik@catharinaziekenhuis.nl",[49,66],{"facility":50,"status":25,"city":51,"state":52,"zip":53,"country":54,"countryCode":55,"cosmosGeoPoint":56,"geoPoint":61,"contacts":62},"University Hospitals Leuven","Leuven","Vlaams Brabant","3000","Belgium","BE",{"type":57,"coordinates":58},"Point",[59,60],4.70093,50.87959,{"lat":60,"lon":59},[63],{"name":35,"role":42,"phone":64,"phoneExt":25,"email":65},"+32 16 33 22 11","wouter.oosterlinck@uzleuven.be",{"facility":67,"status":25,"city":68,"state":68,"zip":69,"country":70,"countryCode":71,"cosmosGeoPoint":72,"geoPoint":76,"contacts":77},"Catharina Hospital Eindhoven","Eindhoven","5623 EJ","Netherlands","NL",{"type":57,"coordinates":73},[74,75],5.47778,51.44083,{"lat":75,"lon":74},[78,79],{"name":32,"role":42,"phone":43,"phoneExt":25,"email":44},{"name":46,"role":42,"phone":43,"phoneExt":25,"email":47},{"type":33,"investigatorFullName":81,"investigatorTitle":82,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"Ferdi Akca","Principal Investigator",[84,85],{"name":36,"class":6},{"name":86,"class":6},"Eindhoven University of Technology","100617093","multivessel-minimally-invasive-coronary-bypass-grafting-as-hybrid-revascularization-versus-conventional-off-pump-coronary-artery-bypass-grafting-100617093",false,"NCT07314138","Multivessel Minimally Invasive Coronary Bypass Grafting as HYBRID Revascularization Versus Conventional Off-pump Coronary Artery Bypass Grafting","MICRA-HYBRID Trial: A Randomized Controlled Trial of 'Multivessel Minimally Invasive Coronary Bypass Grafting as HYBRID Revascularization Versus Conventional Off-Pump Coronary Artery Bypass Grafting'","MICRA-HYBRID","Inclusion Criteria:\n\n* Patients with three-vessel disease (either angiographic stenoses \\>70% or a fractional flow reserve value ≤0.80)\n* Left main diameter stenosis ≥50% or a left main intravascular ultrasound minimal luminal area of ≤4.5 mm2 or fractional flow reserve value ≤0.80 combined with significant CAD of the right coronary artery\n\nExclusion Criteria:\n\nA potential participant who meets any of the following criteria will be excluded from participation in this study:\n\n* Age \\\u003C 18 or \\> 85 years\n* Chronic total occlusion of the RCA\n* In-stent RCA restenosis\n* RCA stenosis with high-risk clinical features requiring urgent PCI or surgical revasculari-zation.\n* Reverse hybrid coronary revascularization, defined as PCI-RCA followed by surgical re-vascularization.\n* Acute cardiac ischemia necessitating immediate intervention.\n* EF \\\u003C 30 %\n* eGFR \\\u003C 30 ml\u002Fmin\n* Indication for concomitant cardiac surgery (e.g. valve or arrhythmia surgery) or non-cardiac surgery\n* Previous thoracic or cardiac surgery, mediastinal irradiation, significant trauma to the chest\n* Preoperative severe end-organ dysfunction (dialysis, liver failure, respiratory failure) or cancer.\n* Hemodynamically significant left subclavian stenosis\n* Severe chest wall deformities\n* History of pericarditis\n* Body mass index \\> 40 Kg\u002Fm2.",true,"ALL","18 Years","85 Years",{"count":100,"type":101},250,"ESTIMATED","INTERVENTIONAL",[104],"NA","The MICRA-HYBRID trial is a prospective, multicenter, randomized controlled study comparing multivessel hybrid coronary revascularization (HCR) as minimally invasive arterial bypass grafting to left-sided coronary targets (LAD and LCx) plus PCI of the RCA versus conventional off-pump coronary artery bypass grafting (OPCAB) via median sternotomy in patients with three-vessel coronary artery disease. The primary goal is to evaluate whether multivessel-HCR provides superior 30-day \"textbook\" clinical outcomes (mortality, MI, stroke, re-exploration for bleeding, and other complications) while improving perioperative recovery and long-term cardiovascular outcomes.",[107,108,109,110],"Coronary Artery Disease (CAD)","Bypass, Cardiopulmonary","Minimally Invasive Coronary Revascularization Surgery","Off-pump Coronary Artery Bypass",[112,113,114,115,116],"minimally invasive coronary surgery","percutaneous coronary intervention","off-pump coronary artery bypass grafting","hybrid coronary revascularization","heart surgery","NOT_YET_RECRUITING","2025-12-23",{"date":120,"type":121},"2026-01-02","ACTUAL",{"date":123,"type":101},"2026-04-01",{"date":125,"type":101},"2034-05-01",{"name":5,"class":6},2]