[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100569686":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":10,"centralContacts":20,"locations":30,"responsibleParty":61,"collaborators":10,"id":65,"slug":66,"hasResults":67,"nctId":68,"briefTitle":69,"officialTitle":70,"acronym":10,"eligibilityCriteria":71,"healthyVolunteers":67,"sex":72,"minAge":73,"maxAge":10,"enrollmentInfo":74,"targetDuration":77,"studyType":78,"phases":10,"briefSummary":79,"conditions":80,"keywords":87,"overallStatus":33,"whyStopped":10,"lastUpdateSubmitDate":116,"lastUpdatePostDateStruct":117,"startDateStruct":120,"completionDateStruct":122,"leadSponsor":124,"locationsCount":125},{"fullName":5,"class":6},"Laboratory of Movement, Condorcet, Tournai, Belgium","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Critically Ill Patients in ICU",null,"This cohort consists of adult patients aged over 18 years who are admitted to the ICU at Epicura Hornu Hospital between October 14, 2024, and November 15, 2024 (to be updated). The study will investigate muscle thickness variations and fluid balance using ultrasound and bioelectrical impedance analysis (BIA). Informed consent will be obtained from the patients or their legal representatives.",[13],"Device: Ultrasound and Bioelectrical Impedance Analysis for Muscle Thickness and Fluid Balance Assessment Translation",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":10},"DEVICE","Ultrasound and Bioelectrical Impedance Analysis for Muscle Thickness and Fluid Balance Assessment Translation","This intervention involves the use of ultrasound and bioelectrical impedance analysis (BIA) to monitor changes in muscle thickness and assess fluid balance in critically ill patients. Measurements will be taken daily during the patients' ICU stay, with a focus on rectus femoris, tibialis anterior, and biceps brachii muscles, as well as total body fluid compartments. The study aims to explore correlations between muscle thickness variations, fluid balance, and patient outcomes.",[9],[21,26],{"name":22,"role":23,"phone":24,"phoneExt":10,"email":25},"Cheryl E HICKMANN, PhD","CONTACT","+32488381526","c.hickmannopazo@condorcet.be",{"name":27,"role":23,"phone":28,"phoneExt":10,"email":29},"Frederic Duprez, Phd","0032475857104","frederic.duprez@condorcet.be",[31,52],{"facility":32,"status":33,"city":34,"state":35,"zip":36,"country":37,"countryCode":38,"cosmosGeoPoint":39,"geoPoint":44,"contacts":45},"Epicura site Hornu","RECRUITING","Boussu","Hainaut","7301","Belgium","BE",{"type":40,"coordinates":41},"Point",[42,43],3.7944,50.43417,{"lat":43,"lon":42},[46,48],{"name":47,"role":23,"phone":24,"phoneExt":10,"email":25},"Cheryl E Hickmann, PT, PhD",{"name":49,"role":23,"phone":50,"phoneExt":10,"email":51},"Sarah S Boutoubat, Bachelor (C)","0033661251992","sarah.boutoubat@condorcet.be",{"facility":32,"status":33,"city":34,"state":10,"zip":36,"country":37,"countryCode":38,"cosmosGeoPoint":53,"geoPoint":55,"contacts":56},{"type":40,"coordinates":54},[42,43],{"lat":43,"lon":42},[57,59,60],{"name":58,"role":23,"phone":24,"phoneExt":10,"email":25},"Cheryl E Hickmann, PhD",{"name":27,"role":23,"phone":28,"phoneExt":10,"email":29},{"name":49,"role":23,"phone":10,"phoneExt":10,"email":10},{"type":62,"investigatorFullName":63,"investigatorTitle":64,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"SPONSOR_INVESTIGATOR","Dr F Duprez","Physiotherapist \u002F Professor at Provincial High School Condorcet (PhD) & Director of the Unité de recherche et d'innovation Condorcet EpiCURA (URICE)","100569686","muscle-and-subcutaneous-tissue-variation-by-ultrasound-and-impedance-linked-to-fluid-balance-in-icu-patients-100569686",false,"NCT06697470","Muscle and Subcutaneous Tissue Variation by Ultrasound and Impedance Linked to Fluid Balance in ICU Patients","Cross-sectional Study on the Variation of Muscle Thickness and Subcutaneous Tissues by Ultrasound and Bioelectrical Impedance in Association with the Fluid Balance of Patients in Intensive Care","Inclusion Criteria:\n\n* Adults aged over 18 years.\n* Patients present and admitted to the ICU at Epicura Hornu Hospital between October 14, 2024, and November 15, 2024 (to be updated).\n* Informed consent to participate in the study has been signed by the patient or their legal representative.\n\nExclusion Criteria :\n\n* Patients in post-operative or other surveillance with an expected ICU stay of less than 48 hours.\n* Patients for whom a decision to withdraw therapy has been made prior to inclusion.\n* Presence of skin conditions (e.g., wounds or ulcers) that hinder ultrasound measurements or the application of skin electrodes.\n* Pregnancy.\n* Presence of an implanted pacemaker or defibrillator.","ALL","18 Years",{"count":75,"type":76},40,"ESTIMATED","5 Days","OBSERVATIONAL","This cross-sectional study aims to investigate the relationship between variations in muscle thickness and subcutaneous tissue, measured by ultrasound, and fluid compartments, evaluated using bioelectrical impedance analysis (BIA), in critically ill patients in the intensive care unit (ICU). Critically ill patients frequently experience muscle wasting and tissue edema due to a combination of inflammation, immobilization, and aggressive fluid resuscitation protocols designed to counteract hemodynamic instability.\n\nUltrasound is widely used to monitor muscle thickness because it is fast, non-invasive, and repeatable. However, muscle thickness measurements during the first days of ICU admission may be influenced by fluid overload, which causes edema and might lead to an overestimation of actual muscle mass. Bioelectrical impedance analysis (BIA) is a complementary tool that assesses both intra- and extracellular fluid compartments. This study aims to correlate daily fluid balance with changes in muscle thickness and subcutaneous tissue measured by ultrasound, and to determine if BIA can accurately reflect fluid status and potentially identify edema in these patients.\n\nFurthermore, at ICU discharge, patients' muscle strength will be assessed using both the MRC-sum score (0-60) and handgrip strength (using a Jamar dynamometer), to investigate whether the presence of edema at discharge correlates with muscle strength deficits. Data collection will occur daily, tracking fluid balance, clinical parameters, and body weight, alongside ultrasound and BIA measurements in a standardized position. The study will help clarify the interactions between fluid management, muscle mass changes, and clinical outcomes in critically ill patients, providing valuable insight into early rehabilitation strategies.",[81,82,83,84,85,86],"Weakness Acquired in the ICU","Muscle Wasting","Edema","Fluid Overload","Critical Illness","Intensive Care Unit (ICU) Patients",[88,89,90,91,92,93,94,95,96,97,98,99,100,101,102,103,104,105,106,107,108,109,110,111,112,113,114,115],"Muscle thickness","Subcutaneous tissue","Ultrasound","Bioelectrical impedance analysis","BIA","Fluid balance","ICU (intensive care unit)","Muscle strength","MRC-sum score","Grip strength","Edema assessment","Critical care","Skeletal muscle","Hydration status","Muscle echogenicity","ICU-acquired weakness","Fluid compartments","Extracellular water","Intracellular water","Body composition","Bedside ultrasound","Fluid management","Early mobilization","Volume overload","Tissue edema","Body water compartments","Length of ICU stay","Muscle quality","2024-11-17",{"date":118,"type":119},"2024-11-20","ACTUAL",{"date":121,"type":119},"2024-10-21",{"date":123,"type":76},"2024-11-15",{"name":63,"class":6},2]