[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100448164":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":25,"locations":35,"responsibleParty":54,"collaborators":19,"id":56,"slug":57,"hasResults":58,"nctId":59,"briefTitle":60,"officialTitle":61,"acronym":19,"eligibilityCriteria":62,"healthyVolunteers":63,"sex":64,"minAge":65,"maxAge":19,"enrollmentInfo":66,"targetDuration":19,"studyType":69,"phases":70,"briefSummary":72,"conditions":73,"keywords":75,"overallStatus":37,"whyStopped":19,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":87},{"fullName":5,"class":6},"VA Office of Research and Development","FED",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Exercise training","EXPERIMENTAL","Patients with HFpEF will participate in the 8 weeks of supervised, two-legged, knee extensor exercise training for 3 days per week. Each exercise session will involve a 5-min warm-up and a 5-min cool-down, and exercise intensity will range between 40%-90% of maximal work rate. Maximal work rate will be re-assessed every two weeks.",[13],"Other: Exercise training",[15],{"type":16,"name":9,"description":17,"armGroupLabels":18,"otherNames":19},"OTHER","Patients with HFpEF will undergo 8 weeks of exercise training.",[9],null,[21],{"name":22,"affiliation":23,"role":24},"Kanokwan Bunsawat, PhD","VA Salt Lake City Health Care System, Salt Lake City, UT","PRINCIPAL_INVESTIGATOR",[26,31],{"name":22,"role":27,"phone":28,"phoneExt":29,"email":30},"CONTACT","(801) 582-1565","1951","Kanokwan.Bunsawat@va.gov",{"name":32,"role":27,"phone":28,"phoneExt":33,"email":34},"David W Wray, PhD","4162","David.Wray2@va.gov",[36],{"facility":23,"status":37,"city":38,"state":39,"zip":40,"country":41,"countryCode":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":49},"RECRUITING","Salt Lake City","Utah","84148-0001","United States","US",{"type":44,"coordinates":45},"Point",[46,47],-111.89105,40.76078,{"lat":47,"lon":46},[50,52,53],{"name":22,"role":27,"phone":51,"phoneExt":29,"email":30},"801-582-1565",{"name":32,"role":27,"phone":28,"phoneExt":33,"email":34},{"name":22,"role":24,"phone":19,"phoneExt":19,"email":19},{"type":55,"investigatorFullName":19,"investigatorTitle":19,"investigatorAffiliation":19,"oldNameTitle":19,"oldOrganization":19},"SPONSOR","100448164","muscle-blood-flow-regulation-in-hfpef-100448164",false,"NCT05115890","Muscle Blood Flow Regulation in HFpEF","Mechanisms of Impaired Skeletal Muscle Blood Flow and Exercise Intolerance in Veterans With Heart Failure With Preserved Ejection Fraction: Efficacy of Knee Extensor Training","Inclusion Criteria:\n\n* Age 18 years or older and able to give written informed consent\n* New York Heart Association (NYHA) functional class II or III\n* Left Ventricular Ejection Fraction (LVEF) \\> 50%\n* Plasma Brain Natriuretic Peptide (BNP) \\>200 pg\u002FmL or NT-proBNP 400 pg\u002FmL at enrollment\n\nExclusion Criteria:\n\n* Prior EF of \\\u003C50%.\n* NYHA Class IV or HF that cannot be stabilized on optimized pharmacotherapy\n* Acute coronary syndrome, infiltrative cardiomyopathy, or myocarditis\n* Patients with HFpEF secondary to significant uncorrected primary valvular disease (except mitral regurgitation secondary to left ventricular dysfunction)\n* Orthopedic limitations that would prohibit knee-extensor exercise\n* Women currently taking hormone replacement therapy (HRT) will be excluded from the proposed studies due to the direct vascular effects of HRT\n* Women who are pregnant or may become pregnant, but the typical age of female patients with HFpEF will be postmenopausal\n* Current smokers",true,"ALL","18 Years",{"count":67,"type":68},35,"ESTIMATED","INTERVENTIONAL",[71],"NA","Heart failure with preserved ejection (HFpEF) disproportionately affects Veterans and is the number one reason for hospital discharge in the VA Health Care System. Exercise intolerance is a common complication experienced by patients with HFpEF, perpetuating physical inactivity and accelerating disease progression. This research proposal aims to elucidate mechanisms responsible for inadequate skeletal muscle blood flow and exercise intolerance in patients with HFpEF compared with healthy controls as well as following 8 weeks of exercise training in patients with HFpEF only.",[74],"HFpEF",[74,76,77],"Muscle Blood Flow","Exercise Tolerance","2026-04-20",{"date":80,"type":81},"2026-04-21","ACTUAL",{"date":83,"type":81},"2022-07-01",{"date":85,"type":68},"2028-02-29",{"name":5,"class":6},1]