[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100583002":3},{"organization":4,"armGroups":7,"interventions":29,"overallOfficials":38,"centralContacts":42,"locations":28,"responsibleParty":48,"collaborators":28,"id":51,"slug":52,"hasResults":53,"nctId":54,"briefTitle":55,"officialTitle":55,"acronym":56,"eligibilityCriteria":57,"healthyVolunteers":58,"sex":59,"minAge":60,"maxAge":61,"enrollmentInfo":62,"targetDuration":28,"studyType":65,"phases":66,"briefSummary":68,"conditions":69,"keywords":71,"overallStatus":73,"whyStopped":28,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":81,"locationsCount":28},{"fullName":5,"class":6},"Chengdu Sport University","OTHER",[8,14,19,24],{"label":9,"type":10,"description":11,"interventionNames":12},"Low-intensity group","EXPERIMENTAL","Firstly, they received the same health education as the control group. Subsequently, the elderly individuals with Knee Osteoarthritis (KOA) underwent five interventions per week targeting the quadriceps femoris muscle. For each intervention, the quadriceps performed an isometric contraction and relaxation for 1 second each. The intervention consisted of 10 repetitions per set of Muscle Isometric Contraction (MIC), guided by a rhythmic timer, for a total of 10 sets, with a 30-second rest between sets. The entire intervention lasted for 16 weeks.",[13],"Other: Low-intensity group",{"label":15,"type":10,"description":16,"interventionNames":17},"Medium-intensity group","Firstly, they received the same health education as the control group. Subsequently, the elderly individuals with Knee Osteoarthritis (KOA) underwent five interventions per week targeting the quadriceps femoris muscle. For each intervention, the quadriceps performed an isometric contraction and relaxation for 1 second each. The intervention consisted of 20 repetitions per set of Muscle Isometric Contraction (MIC), guided by a rhythmic timer, for a total of 10 sets, with a 30-second rest between sets. The entire intervention lasted for 16 weeks.",[18],"Other: Medium-intensity group",{"label":20,"type":10,"description":21,"interventionNames":22},"High-intensity group","Firstly, they received the same health education as the control group. Subsequently, the elderly individuals with Knee Osteoarthritis (KOA) underwent five interventions per week targeting the quadriceps femoris muscle. For each intervention, the quadriceps performed an isometric contraction and relaxation for 1 second each. The intervention consisted of 30 repetitions per set of Muscle Isometric Contraction (MIC), guided by a rhythmic timer, for a total of 10 sets, with a 30-second rest between sets. The entire intervention lasted for 16 weeks.",[23],"Other: High-intensity group",{"label":25,"type":26,"description":27,"interventionNames":28},"Control group","NO_INTERVENTION","Health Education: All participants received standardized health guidance, which was delivered in the form of a weekly 60-minute lecture. The content of the lectures included the following:\n\nEmphasizing the importance of close cooperation with medical professionals for maintaining health.\n\nExplaining the etiology, progression, and treatment options for Knee Osteoarthritis (KOA).\n\nDiscussing the positive impact of family and social support on recovery. Providing guidance on establishing healthy daily living habits, such as protecting the affected knee joints, avoiding prolonged walking, climbing, or frequent use of stairs, and correcting poor postures (e.g., prolonged standing, kneeling, and squatting).\n\nFor those who are overweight, weight loss was recommended.",null,[30,34,36],{"type":6,"name":9,"description":11,"armGroupLabels":31,"otherNames":32},[9],[33],"Muscle Isometric Contraction",{"type":6,"name":15,"description":16,"armGroupLabels":35,"otherNames":28},[15],{"type":6,"name":20,"description":21,"armGroupLabels":37,"otherNames":28},[20],[39],{"name":40,"affiliation":5,"role":41},"Liang Cheng","PRINCIPAL_INVESTIGATOR",[43],{"name":44,"role":45,"phone":46,"phoneExt":28,"email":47},"Shuwan Chang","CONTACT","18280314728","changshuwan1025@163.com",{"type":41,"investigatorFullName":49,"investigatorTitle":50,"investigatorAffiliation":5,"oldNameTitle":28,"oldOrganization":28},"Cheng Liang","Director","100583002","muscle-isometric-contraction-for-the-treatment-of-knee-osteoarthritis-100583002",false,"NCT06870656","Muscle Isometric Contraction for the Treatment of Knee Osteoarthritis","KOA","Inclusion Criteria:\n\n* Women aged 60 to 80 years;\n* Based on the diagnostic criteria for knee osteoarthritis (KOA) established by the American College of Rheumatology in 2001, participants with KOA graded 1 to 3 were selected;\n* Compliance with the Declaration of Helsinki and signing of the informed consent form.\n\nExclusion Criteria:\n\n* Cardiovascular diseases;\n* Need for surgery or pharmacological treatment in the near future;\n* Neuromuscular diseases;\n* Currently engaged in regular exercise.",true,"FEMALE","60 Years","80 Years",{"count":63,"type":64},120,"ESTIMATED","INTERVENTIONAL",[67],"NA","This study compares the effects of three different intensities of Muscle Isometric Contraction (MIC) on balance ability, proprioception, muscle strength, KOA symptoms, and inflammatory factors in synovial fluid among elderly individuals with Knee Osteoarthritis (KOA).",[70],"Knee Osteoarthritis (Knee OA)",[56,72],"Muscle isometric contraction","NOT_YET_RECRUITING","2025-03-06",{"date":76,"type":77},"2025-03-11","ACTUAL",{"date":79,"type":64},"2025-09-20",{"date":79,"type":64},{"name":5,"class":6}]