[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100542644":3},{"organization":4,"armGroups":7,"interventions":22,"overallOfficials":29,"centralContacts":33,"locations":42,"responsibleParty":72,"collaborators":10,"id":75,"slug":76,"hasResults":77,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":81,"eligibilityCriteria":82,"healthyVolunteers":77,"sex":83,"minAge":84,"maxAge":10,"enrollmentInfo":85,"targetDuration":88,"studyType":89,"phases":10,"briefSummary":90,"conditions":91,"keywords":95,"overallStatus":45,"whyStopped":10,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":109},{"fullName":5,"class":6},"University Hospital, Antwerp","OTHER",[8,14,18],{"label":9,"type":10,"description":11,"interventionNames":12},"Child A",null,"The impact of sarcopenia in patients with cirrhosis may also be influenced by sex, severity of hepatic dysfunction, and etiology of cirrhosis. For this reason we aim for an homogeneous population, with a balanced distribution over the Child Pugh classification with a homogeneous population of at least 50%.\n\nChild A patients still have a good hepatic function.",[13],"Other: ultrasound",{"label":15,"type":10,"description":16,"interventionNames":17},"Child B","Child B patients have a moderately impaired hepatic function.",[13],{"label":19,"type":10,"description":20,"interventionNames":21},"Child C","Patients with Child C have an advanced hepatic dysfunction, within this group we will also look at patients with acute on chronic liver failure.(ACLF)",[13],[23],{"type":6,"name":24,"description":25,"armGroupLabels":26,"otherNames":27},"ultrasound","Ultrasound of m. quadriceps and m. thenar All ultrasound measurements will be performed in triplicate, with the average of the scores used in final analyses. Four parameters will be evaluated: muscle thickness, muscle cross sectional area, pennation angle and echo intensity (gain, depth and frequency will be kept constant).\n\nHand grip strength measurement: measurement by an electronic hand dynamometer DynEx1TM (MD Systems, Inc. Ohio, USA). The recommendations for the handgrip strength test of the American Society of Hand Therapists will be followed: The maximum of the three values will be considered for analysis.",[9,15,19],[28],"hand grip strength",[30],{"name":31,"affiliation":5,"role":32},"Karolien Dams, MD","PRINCIPAL_INVESTIGATOR",[34,39],{"name":31,"role":35,"phone":36,"phoneExt":37,"email":38},"CONTACT","+3238213635","5175","karolien.dams@uza.be",{"name":40,"role":35,"phone":10,"phoneExt":10,"email":41},"Stany Perkisas, MD, PhD","stany.perkisas@zna.be",[43],{"facility":44,"status":45,"city":46,"state":47,"zip":48,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"University Hospital Antwerp","RECRUITING","Edegem","Antwerpen","2650","Belgium","BE",{"type":52,"coordinates":53},"Point",[54,55],4.44504,51.15662,{"lat":55,"lon":54},[58,59,64,66,68,70,71],{"name":31,"role":35,"phone":36,"phoneExt":37,"email":38},{"name":60,"role":35,"phone":61,"phoneExt":62,"email":63},"Jolien Derdeyn, MD","+328213807","3807","jolien.derdeyn@uza.be",{"name":60,"role":65,"phone":10,"phoneExt":10,"email":10},"SUB_INVESTIGATOR",{"name":67,"role":65,"phone":10,"phoneExt":10,"email":10},"Thomas Vanwolleghem, MD, Phd",{"name":69,"role":65,"phone":10,"phoneExt":10,"email":10},"Philippe Jorens, MD, PhD",{"name":40,"role":65,"phone":10,"phoneExt":10,"email":10},{"name":31,"role":32,"phone":10,"phoneExt":10,"email":10},{"type":32,"investigatorFullName":73,"investigatorTitle":74,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Karolien Dams","Principal Investigator, MD, senior staff intensive care","100542644","muscle-mass-via-ultrasound-in-cirrhosis-mmuscle-100542644",false,"NCT06345547","Muscle Mass Via UltraSound in Cirrhosis (MMUSCLE)","Prospective Observational Cohort Survey to Assess the Prevalence and Development of Sarcopenia and the Correlation of Muscle Mass and Outcome in Patients With Cirrhosis by Skeletal Muscle Ultrasound.","MMUSCLE","Inclusion Criteria:\n\n* diagnosis of cirrhosis and follow-up in the University Hospital of Antwerp\n\nExclusion Criteria:\n\n* known patient will against participation in the study or against the measures applied in the study\n* a decision made prior to inclusion to stop further treatment of the patient within the next 24 hours\n* no complete remission of malignancy including hepatocellular carcinoma within the past 12 months","ALL","18 Years",{"count":86,"type":87},60,"ESTIMATED","2 Years","OBSERVATIONAL","The goal of this observational cohort study is to learn about loss of muscle mass and muscle strength (sarcopenia) in patients with cirrhosis. The main question\\[s\\] it aims to answer are:\n\n* what is the prevalence and development of sarcopenia in cirrhosis?\n* what is the role of malnutrition? Participants will\n\n  * undergo a muscle ultrasound of the lower and upper limb muscles\n  * handgrip strength will be measured\n  * malnutrition screening and assessment\n  * complete a questionnaire to assess quality of life",[92,93,94],"Sarcopenia","Cirrhosis","Malnutrition",[96,97,98,99],"sarcopenia","cirrhosis","malnutrition","skeletal muscle ultrasound","2026-04-27",{"date":102,"type":103},"2026-05-01","ACTUAL",{"date":105,"type":103},"2024-05-06",{"date":107,"type":87},"2028-03-31",{"name":5,"class":6},1]