[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100612269":3},{"organization":4,"outcomesModule":7,"designInfo":22,"detailedDescription":29,"studyPopulation":21,"armGroups":30,"interventions":38,"overallOfficials":47,"centralContacts":56,"locations":62,"responsibleParty":95,"collaborators":99,"id":103,"slug":104,"hasResults":105,"nctId":106,"briefTitle":107,"officialTitle":108,"acronym":21,"eligibilityCriteria":109,"healthyVolunteers":110,"sex":111,"minAge":112,"maxAge":113,"enrollmentInfo":114,"targetDuration":21,"studyType":117,"phases":118,"briefSummary":119,"conditions":120,"keywords":124,"overallStatus":65,"whyStopped":21,"lastUpdateSubmitDate":130,"lastUpdatePostDateStruct":131,"startDateStruct":134,"completionDateStruct":136,"leadSponsor":138,"locationsCount":139},{"fullName":5,"class":6},"Universite de Picardie Jules Verne","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":16,"otherOutcomes":21},[9,13],{"measure":10,"description":11,"timeFrame":12},"Distribution of muscle synergies derived by non-negative matrix factorization","Changes in the activation of the muscle synergies during the gait cycle.","Before intervention, after intervention (10 minutes after cream application)",{"measure":14,"description":15,"timeFrame":12},"Changes in Muscle Synergy Composition derived by non-negative matrix factorization.","Changes in the composition of muscle synergies (i.e., the individuals muscles that comform one muscle synergy)",[17],{"measure":18,"description":19,"timeFrame":20},"Tampa Scale for Kinesiophobia (TSK)","Tampa Scale of Kinesiophobia total score (17-68). Users rate 17 statements in a scale from 1 (Strongly disagree) to 4 (Strongly agree).","Before intervention.",null,{"allocation":23,"interventionModel":24,"interventionModelDescription":21,"primaryPurpose":25,"observationalModel":21,"timePerspective":21,"maskingInfo":26},"NA","SINGLE_GROUP","BASIC_SCIENCE",{"masking":27,"maskingDescription":28,"whoMasked":21},"NONE","Participants are not aware that a cream applied to them (neutral cream) does not produce any pain.","Participants will be recruited through university announcements. Eligibility will be determined by a screening process that assesses prior experience with capsaicin cream. Healthy adults aged 18-35 who meet the inclusion criteria will be enrolled and assigned to experimental Group (\"Prior Experience\"): Individuals who report a prior painful experience with capsaicin cream.\n\nParticipants will complete a first session consisting on a walking assessment on a treadmill. The speed will be incrementally increased from 0.8 m\u002Fs to 1.1 m\u002Fs. Throughout this task, muscle activity will be recorded via electromyography (EMG), and ground reaction forces will be captured by force platforms embedded in the treadmill.\n\nFollowing the initial walk, participants will complete a set of standardized questionnaires to establish baseline scores for pain perception (Visual Analog Scale, VAS), fear of movement (Tampa Scale of Kinesiophobia, TSK), and pain catastrophizing (Pain Catastrophizing Scale, PCS).\n\nThen, a capsaicin cream will be applied to the knee, specifically in the area between the lateral epicondyles of the femur, in a 4 cm wide band. Participants will immediately fill out the VAS to report any pain sensations. The walking assessment is repeated, measuring the same physiological signals (EMG and ground reaction forces).\n\nThe participants will come to the laboratory a second time to measure the same outcomes but, instead of applying capsaicin again, they will receive an inert cream presented as capsaicin (neutral massage cream MEDICAFARM). The procedure will be repeated.\n\nThe primary objective is to determine whether a prior painful experience with capsaicin causes individuals to generalize that pain memory to a neutral sensation, leading to different outcomes than in those who only have a negative expectation. We will specifically investigate the magnitude of this effect on muscle synergies.",[31],{"label":32,"type":33,"description":34,"interventionNames":35},"Prior Experience Group","EXPERIMENTAL","Participants in this arm have experienced capsaicin cream before and will be given a neutral cream. They will be told that the cream contains capsaicin and will cause pain.",[36,37],"Other: Pain expectation conditioning","Other: Gait assesment",[39,43],{"type":6,"name":40,"description":41,"armGroupLabels":42,"otherNames":21},"Pain expectation conditioning","Participants receive a neutral cream with no real harmful effects with verbal and behavioral suggestions that it may cause localized pain. Researchers wear gloves during application and emphasize the potential discomfort, stating effects may intensify with movement.",[32],{"type":6,"name":44,"description":45,"armGroupLabels":46,"otherNames":21},"Gait assesment","Gait will be assessed both before and after cream application. Each assessment will consist of walking on a treadmill at varying speeds while physiological data (EMG) is recorded. Identical questionnaires (VAS, TAMPA, and PCS) will be administered immediately following the first gait assessment.",[32],[48,52,54],{"name":49,"affiliation":50,"role":51},"Thierry Lelard, PhD, HDR","Lecturer","STUDY_DIRECTOR",{"name":53,"affiliation":50,"role":51},"Maryne Cozette, PhD, Lecturer",{"name":55,"affiliation":50,"role":51},"Guillaume Léonard, PhD, Lecturer",[57],{"name":58,"role":59,"phone":60,"phoneExt":21,"email":61},"Jennifer Burgos-Tirado, M.Sc.A., Ing.","CONTACT","+33 7 71 27 11 35","jennifer.burgos.tirado@u-picardie.fr",[63,80],{"facility":64,"status":65,"city":66,"state":21,"zip":21,"country":67,"countryCode":68,"cosmosGeoPoint":69,"geoPoint":74,"contacts":75},"Centre de Recherche sur le Vieillissement","RECRUITING","Sherbrooke","Canada","CA",{"type":70,"coordinates":71},"Point",[72,73],-71.89908,45.40008,{"lat":73,"lon":72},[76],{"name":77,"role":59,"phone":78,"phoneExt":21,"email":79},"Guillaume Léonard, PhD","819-829-7131","guillaume.leonard2@usherbrooke.ca",{"facility":81,"status":65,"city":82,"state":21,"zip":21,"country":83,"countryCode":84,"cosmosGeoPoint":85,"geoPoint":89,"contacts":90},"Université de Picardie Jules Verne","Amiens","France","FR",{"type":70,"coordinates":86},[87,88],2.3,49.9,{"lat":88,"lon":87},[91],{"name":92,"role":59,"phone":93,"phoneExt":21,"email":94},"Said Ahmaidi","+33 3 22 82 74 41","said.ahmaidi@u-picardie.fr",{"type":96,"investigatorFullName":97,"investigatorTitle":98,"investigatorAffiliation":5,"oldNameTitle":21,"oldOrganization":21},"PRINCIPAL_INVESTIGATOR","Jennifer Burgos Tirado","Researcher - Ph.D student",[100],{"name":101,"class":102},"Mitacs","INDUSTRY","100612269","muscle-synergies-in-pain-and-pain-anticipation-100612269",false,"NCT07251387","Muscle Synergies in Pain and Pain Anticipation","Test-retest Fidelity of a Tool for Calculation of Muscle Synergies","Inclusion Criteria:\n\n* Aged 18-35 years old\n* Healthy participant with no self-reported diagnosed neurological, musculoskeletal, or cardiovascular disorders\n* Body Mass Index (BMI) \\\u003C 30\n* Ability to walk unaided for at least 10 minutes without major physical limitations\n\nExclusion Criteria:\n\n* Presence of pain at the time of testing\n* Self-reported diagnosed condition affecting mobility\n* Known allergy to any component of the study cream\n* Allergy to EMG electrode adhesives\n* Inability to stand unassisted for more than 1 minute\n* Inability to walk\u002Frun at the required speed and distance\n* Weight exceeding 150 kg (due to treadmill limitations)\n* Recent intake (prior intervention) of:\n* Analgesics (within 6 hours)\n* Cigarettes (within 6 hours)\n* Caffeine (within 2 hours)\n* Skin lesions at the cream application site\n* Pregnancy\n* Failure to understand instructions\n* Daytime pain reported by participant on day of experimentation",true,"ALL","18 Years","35 Years",{"count":115,"type":116},12,"ESTIMATED","INTERVENTIONAL",[23],"This study investigates how the anticipation of pain affects muscle synergies. One group will be recruited who will first experience actual pain from capsaicin cream and are then presented with a harmless cream deceptively labeled as capsaicin. The changes in muscle synergies will be measured during walking tasks.",[121,122,123],"Pain","Nocebo Effect","Pain Anticipation",[125,126,121,127,128,129],"Nocebo effect","Pain anticipation","Gait","Motricity","Muscle synergies","2026-06-08",{"date":132,"type":133},"2026-06-11","ACTUAL",{"date":135,"type":133},"2026-01-01",{"date":137,"type":116},"2027-10-01",{"name":5,"class":6},2]