[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100541519":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":27,"centralContacts":32,"locations":41,"responsibleParty":59,"collaborators":61,"id":66,"slug":67,"hasResults":68,"nctId":69,"briefTitle":70,"officialTitle":71,"acronym":10,"eligibilityCriteria":72,"healthyVolunteers":73,"sex":74,"minAge":75,"maxAge":76,"enrollmentInfo":77,"targetDuration":10,"studyType":80,"phases":10,"briefSummary":81,"conditions":82,"keywords":84,"overallStatus":43,"whyStopped":10,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":98},{"fullName":5,"class":6},"University of Graz","OTHER",[8,12,15],{"label":9,"type":10,"description":11,"interventionNames":10},"Group 1: healthy individuals (cross-sectional study)",null,"Typically developed adolescents and young adults will be recruited and measured once within the cross-sectional study.",{"label":13,"type":10,"description":14,"interventionNames":10},"Group 2: mildly affected individuals with cerebral palsy (cross-sectional study)","Mildly affected adolescents and young adults will be recruited and measured once within the cross-sectional study.",{"label":16,"type":10,"description":17,"interventionNames":18},"Group 3: moderately and severely affected individuals with cerebral palsy (cross-sectional study)","The results of the baseline assessment (T0) of the adolescents and young adults with moderate to severe cerebral palsy will be compared with group 1 and group 2.\n\nAfter the baseline assessment (T0) also used for the group comparison (see description above), group 3 enters a 12-week control period following daily routines. After the 12 weeks, the individuals will be assessed (T1) and will then start with the 12-week cardiorespiratory fitness training. The final assessment (T2) will terminate study participation of group 3.",[19],"Other: Cardiorespiratory fitness training",[21],{"type":6,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"Cardiorespiratory fitness training","Cardiorespiratory fitness training will be performed two times a week for one hour in small groups (4-5 people). The training will be conducted outdoors at track and field facilities with at least two coaches.",[16],[26],"Frame Running",[28],{"name":29,"affiliation":30,"role":31},"Annika Kruse, Dr.","Institute of Human Movement Science, Sport and Health, University of Graz","PRINCIPAL_INVESTIGATOR",[33,37],{"name":29,"role":34,"phone":35,"phoneExt":10,"email":36},"CONTACT","00433163802329","annika.kruse@uni-graz.at",{"name":38,"role":34,"phone":39,"phoneExt":10,"email":40},"Martin Svehlik, Dr. med.","004331638514129","martin.svehlik@medunigraz.at",[42],{"facility":30,"status":43,"city":44,"state":10,"zip":45,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":54},"RECRUITING","Graz","8010","Austria","AT",{"type":49,"coordinates":50},"Point",[51,52],15.44197,47.06733,{"lat":52,"lon":51},[55],{"name":56,"role":34,"phone":57,"phoneExt":10,"email":58},"Sebastian Ruin, Univ.-Prof.","00433163802336","sebastian.ruin@uni-graz.at",{"type":60,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[62,64],{"name":63,"class":6},"Medical University of Graz",{"name":65,"class":6},"Karolinska Institutet","100541519","muscle-tendon-pathology-and-metabolic-dysregulation-in-cp-100541519",false,"NCT06330922","Muscle-tendon Pathology and Metabolic Dysregulation in CP","Muscle-tendon Pathology, Metabolic Dysregulation and Chronic Inflammation in Adolescents and Young Adults With Moderate to Severe Spastic Cerebral Palsy","Inclusion Criteria:\n\n* spastic cerebral palsy\n* mildly, moderately or severly affected (Gross Motor Function Classification System level I-IV)\n* age range 14 - 30 years\n* ability to accept and follow verbal instructions\n* strong communication skills\n* sufficient vision (visual function that enables safe movement with reference to people and obstacles)\n* less than 15 hours of experience with the Frame Runners; healthy peers in the same age range\n\nExclusion Criteria:\n\n* other forms of cerebral palsy\n* orthopaedic surgery in the last 12 months\n* Botulinum toxin application in the last 6 months",true,"ALL","14 Years","30 Years",{"count":78,"type":79},50,"ESTIMATED","OBSERVATIONAL","The main aim of this project is to gain knowledge about the muscle-tendon pathology of moderately to severely affected young people with cerebral palsy and their risk for cardiometabolic diseases and chronic inflammation. Furthermore, it will be investigated whether there are associations between the existing pathophysiology as well as inactivity and muscle function, cardiometabolic risk factors and inflammation. Moreover, the potential of the target group for adaptation of its muscular, cardiorespiratory, and endocrine system will be investigated.\n\nThe study parameters will be determined in adolescents and young adults aged 14 to 30 years with moderate to severe spastic cerebral palsy and compared with those of their less severely affected and healthy peers (cross-sectional study). In addition, the more affected individuals will participate in a 12-week training intervention (longitudinal study) performed with special tricycles (i.e., Frame Runners).\n\nTo measure the study parameters, ultrasound, strength tests, near-infrared spectroscopy, blood analyses, and spiroergometry will be used. The fitness training will be performed two times a week for 12 weeks with the Frame Runners.",[83],"Cerebral Palsy, Spastic",[85,86,87,26,88],"Cerebral Palsy","Spasticity","Cardiorespiratory Fitness","Muscle","2026-04-28",{"date":91,"type":92},"2026-04-29","ACTUAL",{"date":94,"type":92},"2024-03-08",{"date":96,"type":79},"2027-03-31",{"name":5,"class":6},1]