[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100532626":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":15,"centralContacts":19,"locations":25,"responsibleParty":42,"collaborators":10,"id":45,"slug":46,"hasResults":47,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":47,"sex":53,"minAge":54,"maxAge":55,"enrollmentInfo":56,"targetDuration":10,"studyType":59,"phases":10,"briefSummary":60,"conditions":61,"keywords":10,"overallStatus":27,"whyStopped":10,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":73},{"fullName":5,"class":6},"Tartu University Hospital","OTHER",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"LEAD",null,"LEAD diagnosis confirmed by by ankle-brachial index (≤0,9 or \\>1,3) or angiography. Fontaine I-IV class symptoms.",{"label":13,"type":10,"description":14,"interventionNames":10},"Controls","Matched with LEAD group's patients as much as possible for age, sex, smoking history, hypertension, diabetes, coronary artery disease.",[16],{"name":17,"affiliation":5,"role":18},"Jaak Kals, PhD","PRINCIPAL_INVESTIGATOR",[20],{"name":17,"role":21,"phone":22,"phoneExt":23,"email":24},"CONTACT","731 8292","+372","jaak.kals@ut.ee",[26],{"facility":5,"status":27,"city":28,"state":10,"zip":10,"country":29,"countryCode":30,"cosmosGeoPoint":31,"geoPoint":36,"contacts":37},"RECRUITING","Tartu","Estonia","EE",{"type":32,"coordinates":33},"Point",[34,35],26.72509,58.38062,{"lat":35,"lon":34},[38],{"name":39,"role":21,"phone":40,"phoneExt":10,"email":41},"Liis Roine, MD","+372 731 8457","liis.roine@kliinikum.ee",{"type":18,"investigatorFullName":43,"investigatorTitle":44,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Jaak Kals","Professor of Vasology","100532626","myocardial-dysfunction-evaluation-in-lower-extremity-arterial-disease-patients-with-deformation-analysis-100532626",false,"NCT06215248","Myocardial Dysfunction Evaluation in Lower Extremity Arterial Disease Patients With Deformation Analysis","Assessment of Dysfunction in Left Cardiac Chambers With Strain-analyses in Patients With Lower Extremity Arterial Disease","MEDAL","Inclusion Criteria in LEAD group:\n\n* Fontaine I-IV class symptoms\n* Confirmed diagnosis of LEAD\n\nInclusion Criteria in control group:\n\n* Age 35-85\n* Has to have at least of the following: hypertension, diabetes, coronary artery disease or the patient smokes\n\nExclusion Criteria:\n\n* Age \\\u003C35 or \\>85 years\n* BMI ≥40 kg\u002Fm²\n* Known heart failure in history\n* Any acute or chronic autoimmune or rheumatic disease\n* Cardiac structural disease in history: inflammatory, infiltrative diseases, nonischemic cardiomyopathies\n* Acute coronary syndrome in last 3 months\n* Moderate to severe cardiac valvular disease\n* Cardiac valvular disease operative\u002Finvasive treatment in history\n* Cardiac implantable electronic device (CIED)\n* Transitory ischemic attack or stroke in last 3 months\n* Severe COPD (GOLD C or D)\n* Moderate to severe asthma (according to GINA 2022 criteria)\n* Untreated hypertension (noninvasive blood pressure measurement ≥180\u002F110 mmHg during recruitment)\n* Chronic severe kidney dysfunction (eGFR \\\u003C30 ml\u002Fmin\u002F1,73 m²)\n* Malignant tumor with radiation treatment to thorax, oncologic or biologic treatment in history\n* Chronic hematologic disease (except for anemia)\n* Severe liver dysfunction\n* Malignant tumor with \\\u003C5 years of remission\n* Acute or chronic infectious disease\n* Anemia with hemoglobin \\\u003C80 g\u002FL","ALL","35 Years","85 Years",{"count":57,"type":58},162,"ESTIMATED","OBSERVATIONAL","Single centre observational study to assess lower extremity arterial disease (LEAD) patients' cardiac dysfunction with strain analyses and to assess connections between cardiac dysfunction, metabolomic changes and target organ damage in LEAD.",[62,63],"Peripheral Artery Disease","Heart Failure","2025-12-08",{"date":66,"type":67},"2025-12-16","ACTUAL",{"date":69,"type":67},"2024-02-01",{"date":71,"type":58},"2026-12-31",{"name":5,"class":6},1]