[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100182683":3},{"organization":4,"armGroups":7,"interventions":23,"overallOfficials":31,"centralContacts":36,"locations":45,"responsibleParty":66,"collaborators":12,"id":69,"slug":70,"hasResults":71,"nctId":72,"briefTitle":73,"officialTitle":74,"acronym":12,"eligibilityCriteria":75,"healthyVolunteers":71,"sex":76,"minAge":77,"maxAge":12,"enrollmentInfo":78,"targetDuration":12,"studyType":81,"phases":82,"briefSummary":84,"conditions":85,"keywords":12,"overallStatus":48,"whyStopped":12,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":97},{"fullName":5,"class":6},"Sun Yat-sen University","OTHER",[8,13,19],{"label":9,"type":10,"description":11,"interventionNames":12},"control","NO_INTERVENTION","untreated",null,{"label":14,"type":15,"description":16,"interventionNames":17},"short statin","EXPERIMENTAL","Simvastatin (20 mg) was administered every day for the 5-7 days preoperatively, but not the day of surgery in the statin group. Then simvastatin was re-administered at the second day until 7 days postoperatively.",[18],"Drug: simvastatin",{"label":20,"type":15,"description":21,"interventionNames":22},"long statin","Simvastatin (20 mg) was administered every day for the 5-7 days preoperatively, but not the day of surgery in the statin group. Then simvastatin was re-administered at the second day until 6 months postoperatively.",[18],[24],{"type":25,"name":26,"description":27,"armGroupLabels":28,"otherNames":29},"DRUG","simvastatin","In short statin group: 20 mg per day, start at 5-7 days before surgery and continue for 7 days.\n\nIn long statin group: 20 mg per day, start at 5-7 days before surgery and continue for 6 months.",[20,14],[30],"simcor",[32],{"name":33,"affiliation":34,"role":35},"Jing-song Ou, MD,PhD","The Frist Affiliated Hospital, Sun Yat-sen University","PRINCIPAL_INVESTIGATOR",[37,43],{"name":38,"role":39,"phone":40,"phoneExt":41,"email":42},"Jing-song Ou, MD, PhD","CONTACT","8620-87755766","8238","oujs2000@yahoo.com",{"name":44,"role":39,"phone":40,"phoneExt":41,"email":12},"Zhi-ping Wang, MD, PhD",[46],{"facility":47,"status":48,"city":49,"state":50,"zip":51,"country":52,"countryCode":53,"cosmosGeoPoint":54,"geoPoint":59,"contacts":60},"The First Affiliated Hospital, Sun Yat-sen University","RECRUITING","Guangzhou","Guangdong","510080","China","CN",{"type":55,"coordinates":56},"Point",[57,58],113.25,23.11667,{"lat":58,"lon":57},[61,65],{"name":62,"role":39,"phone":63,"phoneExt":12,"email":64},"Cong-zhi Rao, MD","87333122","raoczh@mail.sysu.edu.cn",{"name":33,"role":35,"phone":12,"phoneExt":12,"email":12},{"type":35,"investigatorFullName":67,"investigatorTitle":68,"investigatorAffiliation":5,"oldNameTitle":12,"oldOrganization":12},"Jing-song Ou","Director","100182683","myocardial-protection-effect-of-simvastatin-undergoing-cardiac-surgery-100182683",false,"NCT01653223","Myocardial Protection Effect of Simvastatin Undergoing Cardiac Surgery","A Study of Simvastatin on Myocardial Protection and Cardiac Function Undergoing Cardiac Surgery With Cardiopulmonary Bypass","Inclusion Criteria:\n\n* More than 18-year-old,\n* Congenital heart disease(not complex),\n* Isolated heart valve disease,\n\nExclusion Criteria:\n\n* Coronary artery disease\n* Allergy for statins\n* Poor liver function,Hepatitis\n* Gestation women and Breast-feeding women","ALL","18 Years",{"count":79,"type":80},369,"ESTIMATED","INTERVENTIONAL",[83],"NA","Statins have been used to low cholesterol to prevent and treat coronary artery diseases. It was also reported that statins could protect endothelial function and cardiac function during coronary artery bypass graft. The investigators recent found simvastatin reduced myocardial injury during noncoronary artery cardiac surgery in single medical center. The investigators further investigate that whether simvastatin can protect myocardium during noncoronary artery cardiac surgery with cardiopulmonary bypass and improve cardiac function with long term use postoperatively in two medical centers.",[86,87],"Congenital Heart Disease","Heart Valve Disease","2023-04-19",{"date":90,"type":91},"2023-04-21","ACTUAL",{"date":93,"type":12},"2013-01",{"date":95,"type":80},"2026-12",{"name":5,"class":6},1]