[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100088734":3},{"organization":4,"armGroups":7,"interventions":7,"overallOfficials":8,"centralContacts":14,"locations":20,"responsibleParty":40,"collaborators":42,"id":74,"slug":75,"hasResults":76,"nctId":77,"briefTitle":78,"officialTitle":79,"acronym":7,"eligibilityCriteria":80,"healthyVolunteers":81,"sex":82,"minAge":7,"maxAge":7,"enrollmentInfo":83,"targetDuration":7,"studyType":86,"phases":7,"briefSummary":87,"conditions":88,"keywords":90,"overallStatus":23,"whyStopped":7,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":104},{"fullName":5,"class":6},"University of British Columbia","OTHER",null,[9,12],{"name":10,"affiliation":5,"role":11},"Bruce Carleton, Pharm. D.","PRINCIPAL_INVESTIGATOR",{"name":13,"affiliation":5,"role":11},"Michael Hayden, MD, Ph.D",[15],{"name":16,"role":17,"phone":18,"phoneExt":7,"email":19},"Bruce Carleton, PharmD.","CONTACT","604-875-2179","bcarleton@popi.ubc.ca",[21],{"facility":22,"status":23,"city":24,"state":25,"zip":26,"country":27,"countryCode":28,"cosmosGeoPoint":29,"geoPoint":34,"contacts":35},"Children's and Women's Health Centre of British Columbia","RECRUITING","Vancouver","British Columbia","V6H 3V4","Canada","CA",{"type":30,"coordinates":31},"Point",[32,33],-123.11934,49.24966,{"lat":33,"lon":32},[36,38],{"name":37,"role":17,"phone":18,"phoneExt":7,"email":19},"Bruce Carleton",{"name":39,"role":11,"phone":7,"phoneExt":7,"email":7},"Bruce Carleton, MD",{"type":11,"investigatorFullName":37,"investigatorTitle":41,"investigatorAffiliation":5,"oldNameTitle":7,"oldOrganization":7},"Study Principal Investigator",[43,45,48,50,52,54,57,60,62,64,66,68,70,72],{"name":44,"class":6},"Genome Canada",{"name":46,"class":47},"Genome British Columbia","INDUSTRY",{"name":49,"class":6},"Child and Family Research Institute",{"name":51,"class":6},"Western University, Canada",{"name":53,"class":6},"Provincial Health Services Authority British Columbia",{"name":55,"class":56},"Health Canada","OTHER_GOV",{"name":58,"class":59},"Canada Gene Cure","UNKNOWN",{"name":61,"class":47},"Eli Lilly and Company",{"name":63,"class":47},"Pfizer",{"name":65,"class":47},"Merck Sharp & Dohme LLC",{"name":67,"class":59},"Canadian Society of Clinical Pharmacology",{"name":69,"class":56},"Canadian Institutes of Health Research (CIHR)",{"name":71,"class":6},"Canada Foundation for Innovation",{"name":73,"class":6},"British Columbia Clinical Genomics Network","100088734","national-active-surveillance-network-and-pharmacogenomics-of-adverse-drug-reactions-in-children-100088734",false,"NCT00414115","National Active Surveillance Network and Pharmacogenomics of Adverse Drug Reactions in Children","Canadian Pharmacogenomics Network for Drug Safety","Inclusion Criteria:\n\n* Children under 19 years who have taken drugs.\n* Biological parents of children who have had an ADR.\n* Patients\u002Fparents who speak and understand English (except in Quebec).\n* Adults (for validation of findings in children)",true,"ALL",{"count":84,"type":85},7000,"ESTIMATED","OBSERVATIONAL","The purpose of the study is (1) to identify and collect samples from children and adults who take drugs and have adverse drug reactions AND children and adults who take drugs and do not experience any adverse drug effects; (2) to determine if genetic differences between the two groups contribute to causing the adverse drug reactions; and (3) to develop patient specific drug dosing guidelines to prevent future adverse drug reactions. We also wish to compare the use of prescription drugs, medical and hospital services and vital statistics between BC participants who experience adverse drug reactions and those who do not.\n\nStudy hypothesis: Genetic differences may contribute to patients' response to drugs and may be responsible for adverse drug reactions.",[89],"Adverse Drug Reaction (ADR)",[91,92,93,94],"Observational controlled study","Genomic biomarkers","Adverse drug reaction","In children OR adults","2026-04-27",{"date":97,"type":98},"2026-05-01","ACTUAL",{"date":100,"type":7},"2005-08",{"date":102,"type":85},"2029-03",{"name":5,"class":6},1]