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According to well-established criteria, PBC is diagnosed in subjects who fulfill two of the three of following criteria:\n\n* elevated alkaline phosphatase and \u002For GGT;\n* positive anti-mitochondrial autoantibodies (titer ≥ 1:40) or PBC-specific antinuclear antibodies (gp-210 and sp100);\n* characteristic histological features of florid bile ducts lesions and granulomatous lesion.\n\nExclusion Criteria:\n\nThe patient has explicitly declared his\u002Fher unwillingness to participate to the study","ALL","18 Years",{"count":463,"type":464},6000,"ESTIMATED","10 Years","OBSERVATIONAL","Primary biliary cholangitis (PBC) is a rare, autoimmune, cholestatic liver disease. No data about the disease epidemiology exist in Italy. Therefore this study aims to develop a national PBC patient database linked to a biological sample storage.",[469],"Primary Biliary Cholangitis",[469,471,472],"Disease phenotypes","National Database","2025-07-24",{"date":475,"type":476},"2025-07-25","ACTUAL",{"date":478,"type":476},"2019-09-19",{"date":480,"type":464},"2029-01-24",{"name":5,"class":6},55]