[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100546126":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":30,"centralContacts":34,"locations":40,"responsibleParty":71,"collaborators":73,"id":75,"slug":76,"hasResults":77,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":81,"eligibilityCriteria":82,"healthyVolunteers":83,"sex":84,"minAge":85,"maxAge":86,"enrollmentInfo":87,"targetDuration":25,"studyType":90,"phases":91,"briefSummary":93,"conditions":94,"keywords":102,"overallStatus":42,"whyStopped":25,"lastUpdateSubmitDate":107,"lastUpdatePostDateStruct":108,"startDateStruct":111,"completionDateStruct":113,"leadSponsor":115,"locationsCount":116},{"fullName":5,"class":6},"Natural Resources Institute Finland","OTHER_GOV",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Rewilding","EXPERIMENTAL","The kindergarten yards are modified with natural elements to increase children's exposure to biodiversity and playground equipment are incorporated to the yards to increase children's physical activity.",[13],"Other: Biodiversity",{"label":15,"type":10,"description":16,"interventionNames":17},"Control","The kindergarten yards are not rewilded with natural elements and the biodiversity is low at the yards. Playground equipment are incorporated to the yards to increase children's physical activity.",[18],"Other: Playground equipment",[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"OTHER","Biodiversity","In rewilding kindergartens, the yards are modified with biological elements, i.e., vegetation and plantation will be added to the yards.",[9],null,{"type":21,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Playground equipment","Playground equipment that increase the physical activity of children will be added to the kindergarten yards.",[15],[31],{"name":32,"affiliation":5,"role":33},"Aki Sinkkonen","PRINCIPAL_INVESTIGATOR",[35],{"name":36,"role":37,"phone":38,"phoneExt":25,"email":39},"Sanna Hurtola","CONTACT","+358295322500","sanna.hurtola@luke.fi",[41,59],{"facility":5,"status":42,"city":43,"state":44,"zip":45,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":54},"RECRUITING","Helsinki","Uusimaa","00970","Finland","FI",{"type":49,"coordinates":50},"Point",[51,52],24.93545,60.16952,{"lat":52,"lon":51},[55],{"name":56,"role":37,"phone":57,"phoneExt":25,"email":58},"Marja Roslund","+358295322256","marja.roslund@luke.fi",{"facility":60,"status":42,"city":61,"state":25,"zip":25,"country":46,"countryCode":47,"cosmosGeoPoint":62,"geoPoint":66,"contacts":67},"Tampere University","Tampere",{"type":49,"coordinates":63},[64,65],23.78712,61.49911,{"lat":65,"lon":64},[68],{"name":69,"role":37,"phone":25,"phoneExt":25,"email":70},"Laura Kummola, Phd","laura.kummola@tuni.fi",{"type":72,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR",[74],{"name":60,"class":21},"100546126","nationwide-research-on-the-rewilding-of-kindergarten-yards-100546126",false,"NCT06390878","Nationwide Research on the Rewilding of Kindergarten Yards","Nationwide Research on the Rewilding of Kindergarten Yards - Vahvistu","Vahvistu","Inclusion Criteria:\n\n* Attendance in kindergarten\n\nExclusion Criteria:\n\n* Use of antibiotics in the year before sampling",true,"ALL","1 Year","5 Years",{"count":88,"type":89},320,"ESTIMATED","INTERVENTIONAL",[92],"NA","Biodiversity is essential for nature and human well-being. Land use has reduced biodiversity in cities that is associated with altered commensal microbiota and a rising burden of immunological disorders among urban children.\n\nThe investigators will estimate how rewilding of kindergarten yards affects commensal microbiome, prevalence of allergies, asthma, atopic dermatitis and infections, cortisol levels, cognitive skills and plasma cytokine levels of children.\n\nOur specific aims are:\n\nTo assess if rewilding diversifies health-associated skin, saliva and gut microbiota and reduces infectious diseases and atopic or allergic symptoms.\n\nAssess whether the rewilding has positive effects on cognitive skills. Assess whether the rewilding changes cortisol and plasma cytokine levels. The investigators will recruit altogether 320 (160 per treatment) study subjects aged between 1-5 to questionnaire study (Task 2), from which 120 study subjects will be analyzed more detailed using microbiological and blood samples (Task 1).",[95,96,97,98,99,100,101],"Microbial Colonization","Atopic Dermatitis","Asthma in Children","Allergy","Cognitive Change","Respiratory Infection","Nature, Human",[103,104,105,22,106],"Commensal microbiome","Atopy","Planetary health","Cognitive skills","2024-06-20",{"date":109,"type":110},"2024-06-24","ACTUAL",{"date":112,"type":110},"2024-05-15",{"date":114,"type":89},"2027-08-30",{"name":5,"class":6},2]