[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100577561":3},{"organization":4,"armGroups":7,"interventions":7,"overallOfficials":8,"centralContacts":13,"locations":21,"responsibleParty":40,"collaborators":7,"id":42,"slug":43,"hasResults":44,"nctId":45,"briefTitle":46,"officialTitle":46,"acronym":7,"eligibilityCriteria":47,"healthyVolunteers":48,"sex":49,"minAge":50,"maxAge":51,"enrollmentInfo":52,"targetDuration":7,"studyType":55,"phases":7,"briefSummary":56,"conditions":57,"keywords":59,"overallStatus":23,"whyStopped":7,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":71},{"fullName":5,"class":6},"ETH Zurich","OTHER",null,[9],{"name":10,"affiliation":11,"role":12},"Jörg Goldhahn, Prof.","dTIP \u002F ETH Zürich","STUDY_CHAIR",[14,18],{"name":10,"role":15,"phone":16,"phoneExt":7,"email":17},"CONTACT","044 633 70 54","jgoldhahn@ethz.ch",{"name":19,"role":15,"phone":16,"phoneExt":7,"email":20},"Susanne Müller, MSc","susanne.mueller@dtip.ethz.ch",[22],{"facility":11,"status":23,"city":24,"state":7,"zip":25,"country":26,"countryCode":27,"cosmosGeoPoint":28,"geoPoint":33,"contacts":34},"RECRUITING","Baden","5404","Switzerland","CH",{"type":29,"coordinates":30},"Point",[31,32],8.30592,47.47333,{"lat":32,"lon":31},[35,37],{"name":36,"role":15,"phone":7,"phoneExt":7,"email":20},"Susanne Müller",{"name":38,"role":15,"phone":7,"phoneExt":7,"email":39},"Sonia Strangio","sonia.strangio@dtip.ethz.ch",{"type":41,"investigatorFullName":7,"investigatorTitle":7,"investigatorAffiliation":7,"oldNameTitle":7,"oldOrganization":7},"SPONSOR","100577561","natural-course-of-initially-metabolic-healthy-obese-individuals-healthy-obesity-100577561",false,"NCT06799897","Natural Course of Initially Metabolic Healthy Obese Individuals (Healthy Obesity)?","Inclusion Criteria:\n\n* Signed Informed Consent Form\n* Age between 18 and 60 years\n* BMI 30-50 kg\u002Fm2\n* Knowledge of German, which requires sufficient written and allow oral patient education\n\nInclusion criteria for initially healthy group\n\n* Blood pressure \\\u003C 140\u002F90 mmHg\n* Normal glucose metabolism\n\n  * HbA1c \\\u003C 6.5 %\n  * Fasting Glucose \\\u003C 7.0 mmol\u002Fl\n* Normal lipid metabolism\n\n  o LDL-cholesterol \\\u003C 5.0 mmol\u002Fl\n* ≤ 2 of the following metabolic syndrome criteria combined (excluding waist circumference)\n* TG \\> 1.7 mmol\u002Fl\n* HDL-cholesterol \\> 1.0 mmol\u002Fl (male) \u002F \\> 1.3 mmol\u002Fl (female)\n* Fasting glucose ≥ 5.6 mmol\u002Fl\n* BP ≥ 130\u002F85 mmHg\n\nExclusion Criteria:\n\n* Pregnancy\n* Medication and \u002F or pathologies that prevent a safe execution of the fat tissue biopsies\n* History of or planned bariatric operation\n* Medical conditions that prevent examinations and testing (e.g. symptomatic cardiovascular diseases)\n* Active Malignant tumor (\\\u003C2a remission)",true,"ALL","18 Years","60 Years",{"count":53,"type":54},300,"ESTIMATED","OBSERVATIONAL","The main goal of this study is to gain a thorough understanding, which specific factors drive the unhealthy sequelae of obesity. Therefore, the investigators want to understand:\n\n1. What distinguishes obese persons without metabolic diseases from those with medical diseases in a cross-sectional comparison?\n2. Which factors drive the conversions from metabolically healthy obesity into a metabolically unhealthy obesity in a longitudinal approach?",[58],"Healthy Obesity, Metabolically",[60,61],"Obesity","Healthy","2025-05-26",{"date":64,"type":65},"2025-05-30","ACTUAL",{"date":67,"type":65},"2023-01-18",{"date":69,"type":54},"2026-01-18",{"name":5,"class":6},1]