[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100596196":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":24,"locations":32,"responsibleParty":47,"collaborators":10,"id":50,"slug":51,"hasResults":52,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":10,"eligibilityCriteria":56,"healthyVolunteers":52,"sex":57,"minAge":58,"maxAge":10,"enrollmentInfo":59,"targetDuration":62,"studyType":63,"phases":10,"briefSummary":64,"conditions":65,"keywords":68,"overallStatus":35,"whyStopped":10,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":79},{"fullName":5,"class":6},"Chinese University of Hong Kong","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Patients with advanced chronic liver disease",null,"Adult patients with advanced chronic liver disease",[13],"Diagnostic Test: Transient elastography",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":10},"DIAGNOSTIC_TEST","Transient elastography","Liver stiffness and spleen stiffness from transient elastography",[9],[21],{"name":22,"affiliation":5,"role":23},"Jimmy CT Lai, MB ChB","PRINCIPAL_INVESTIGATOR",[25,29],{"name":22,"role":26,"phone":27,"phoneExt":10,"email":28},"CONTACT","85235054205","jimmyctlai@cuhk.edu.hk",{"name":30,"role":26,"phone":27,"phoneExt":10,"email":31},"Angel Chim, MSc","angelchim@cuhk.edu.hk",[33],{"facility":34,"status":35,"city":36,"state":10,"zip":10,"country":36,"countryCode":37,"cosmosGeoPoint":38,"geoPoint":43,"contacts":44},"Prince of Wales Hospital","RECRUITING","Hong Kong","HK",{"type":39,"coordinates":40},"Point",[41,42],114.17469,22.27832,{"lat":42,"lon":41},[45,46],{"name":22,"role":26,"phone":27,"phoneExt":10,"email":28},{"name":30,"role":26,"phone":27,"phoneExt":10,"email":31},{"type":23,"investigatorFullName":48,"investigatorTitle":49,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Jimmy Che-To Lai","Assistant Professor (Clinical)","100596196","natural-history-of-advanced-chronic-liver-diseases-100596196",false,"NCT07042308","Natural History of Advanced Chronic Liver Diseases","Natural History of Advanced Chronic Liver Diseases and Factors Associated With Hepatic Events - a Registry Study","Inclusion Criteria:\n\n* Aged 18 or above\n* Known ACLD, defined by:\n\n  * LSM \\> 10kPa or\n  * Clinical cirrhosis, suggested by 1. ultrasonography of the hepatobiliary system shows features of cirrhosis (e.g. shrunken and nodular liver) and portal hypertension (e.g. dilated portal vein, portal-systemic collaterals or varices, splenomegaly, ascites). 2. Oesophagogastroduodenoscopy (OGD) shows presence of oesophageal varices (OV) and\u002For gastric varices (GV) and\u002For portal hypertensive gastropathy.\n\nExclusion Criteria:\n\n* Current or past history of hepatocellular carcinoma (HCC)\n* History of liver transplantation\n* Asplenism or history of splenectomy\n* Serious medical illness with limited life expectancy of less than 6 months\n* Pregnancy\n* Unable to obtain or refusal of informed consent from patient","ALL","18 Years",{"count":60,"type":61},500,"ESTIMATED","10 Years","OBSERVATIONAL","This is a retrospective-prospective registry cohort study. Patients with advanced chronic liver disease (ACLD) will be prospectively invited to this study. The study follow-up duration will be 10 years. The primary outcome is incident hepatic events and liver-related mortality. Participants will undergo annual transient elastography examination.",[66,67],"Cirrhosis","Advanced Chronic Liver Disease",[69],"advanced chronic liver disease","2025-06-25",{"date":72,"type":73},"2025-06-29","ACTUAL",{"date":75,"type":73},"2024-09-25",{"date":77,"type":61},"2035-12",{"name":5,"class":6},1]