[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100258133":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":15,"centralContacts":20,"locations":29,"responsibleParty":50,"collaborators":10,"id":52,"slug":53,"hasResults":54,"nctId":55,"briefTitle":56,"officialTitle":56,"acronym":10,"eligibilityCriteria":57,"healthyVolunteers":58,"sex":59,"minAge":60,"maxAge":61,"enrollmentInfo":62,"targetDuration":10,"studyType":65,"phases":10,"briefSummary":66,"conditions":67,"keywords":71,"overallStatus":32,"whyStopped":10,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":87},{"fullName":5,"class":6},"National Institutes of Health Clinical Center (CC)","NIH",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"1",null,"hemifacial microsomia",{"label":13,"type":10,"description":14,"interventionNames":10},"2","mandibular prognathism",[16],{"name":17,"affiliation":18,"role":19},"Konstantinia Almpani, D.D.S.","National Institute of Dental and Craniofacial Research (NIDCR)","PRINCIPAL_INVESTIGATOR",[21,26],{"name":22,"role":23,"phone":24,"phoneExt":10,"email":25},"Pamela M Orzechowski, R.N.","CONTACT","(301) 402-7373","ps363q@nih.gov",{"name":17,"role":23,"phone":27,"phoneExt":10,"email":28},"(301) 827-1647","nadine.almpani@nih.gov",[30],{"facility":31,"status":32,"city":33,"state":34,"zip":35,"country":36,"countryCode":37,"cosmosGeoPoint":38,"geoPoint":43,"contacts":44},"National Institutes of Health Clinical Center","RECRUITING","Bethesda","Maryland","20892","United States","US",{"type":39,"coordinates":40},"Point",[41,42],-77.10026,38.98067,{"lat":42,"lon":41},[45],{"name":46,"role":23,"phone":47,"phoneExt":48,"email":49},"For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR)","800-411-1222","TTY dial 711","ccopr@nih.gov",{"type":51,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100258133","natural-history-of-craniofacial-anomalies-and-developmental-growth-variants-100258133",false,"NCT02639312","Natural History of Craniofacial Anomalies and Developmental Growth Variants","* INCLUSION CRITERIA:\n\nFor Subjects:\n\n* Age \\> 2 to \\\u003C 100 with craniofacial anomalies\u002Fabnormalities. Affected family member (defined as an individual with a demonstrable relationship, any family relationship no matter how distant, with the above subject in the pedigree) who expresses craniofacial anomalies will be classified as a subject.\n* Able to provide consent, or in the case of minors, have a legally authorized representative to provide consent.\n\nFor Unaffected Family Members:\n\n* These family members are defined as individuals with a demonstrable relationship (any family relationship, no matter how distant) with a proband subject by pedigree who do not express craniofacial anomalies.\n* \\>= 2 years old to \\\u003C= 100 years old.\n* Able to provide consent, or in the case of minors, have a legally authorized representative to provide consent.\n\nFor Healthy Volunteers:\n\n* In good general health.\n\n  -\\>= 6 years old to \\\u003C 100 years old.\n* Able to provide consent, or in the case of minors, have a legally authorized representative to provide consent.\n* Absence of a craniofacial congenital anomaly or malocclusion.\n* No family history of a craniofacial syndrome.\n\nEXCLUSION CRITERIA:\n\nAn individual who meets any of the following criteria will be excluded from participation in this study:\n\nFor All Participants:\n\n* A history of facial trauma requiring surgical treatment and facial reconstruction.\n* Refusal for both genetic testing and CBCT imaging. Participants must agree to at least one of the two (one or the other is required to participate).\n\nFor Healthy Volunteers:\n\n-Female volunteers who are pregnant or nursing.",true,"ALL","2 Years","100 Years",{"count":63,"type":64},2400,"ESTIMATED","OBSERVATIONAL","Background:\n\nSome head and facial abnormalities are rare and present at birth. Others are more common, and may not show up until puberty. These conditions have different causes and characteristics. Researchers want to learn more about these conditions by comparing people with face, head, and neck abnormalities to family members and to healthy volunteers without such conditions.\n\nObjectives:\n\nTo learn more about abnormal development of the face, head, and neck. To determine their genetic variants.\n\nEligibility:\n\nPeople who have not had surgery for facial trauma:\n\nPeople ages 2 and older with craniofacial abnormalities (may participate offsite)\n\nUnaffected relatives ages 2 and older\n\nHealthy volunteers ages 6 and older\n\nDesign:\n\nParticipants will be screened with medical history and physical exam focusing on head, face, and neck\n\nParticipants may be followed for several years. Visits may require staying near the clinic for a few days.\n\nA visit is required for the following developmental stages, along with follow-up visits:\n\nAge 2-6\n\nAge 6-10\n\nAge 11-17\n\nAge 18 and older\n\nVisits may include:\n\nMedical history\n\nPhysical exam\n\nQuestionnaires\n\nOral exam\n\nBlood and urine tests\n\nCheek swab: a cotton swab will be wiped across the inside of the cheek several times.\n\nCone beam CT scan (CBCT): x-rays create an image of the head, face, teeth, and neck. Participants will\n\nstand still or sit on a chair for about 20 minutes while the scanner rotates around the head.\n\nPhotos of the head and face\n\nOffsite participants will provide:\n\nCopies of medical and dental records\n\nLeftover tissue samples from previous surgery\n\nBlood sample or cheek swab",[68,69,70],"Prognathism","Retrognathism","Dentofacial Deformities",[72,73,74,75,76,77],"Craniofacial","Microsomia","Mandibular","Facial Defects","Hasburg Jaw","Natural History","2026-03-14",{"date":80,"type":81},"2026-03-17","ACTUAL",{"date":83,"type":81},"2016-04-18",{"date":85,"type":64},"2046-12-31",{"name":18,"class":6},1]