[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100596078":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":12,"locations":18,"responsibleParty":483,"collaborators":10,"id":485,"slug":486,"hasResults":487,"nctId":488,"briefTitle":489,"officialTitle":489,"acronym":490,"eligibilityCriteria":491,"healthyVolunteers":487,"sex":492,"minAge":10,"maxAge":10,"enrollmentInfo":493,"targetDuration":10,"studyType":496,"phases":10,"briefSummary":497,"conditions":498,"keywords":503,"overallStatus":85,"whyStopped":10,"lastUpdateSubmitDate":510,"lastUpdatePostDateStruct":511,"startDateStruct":514,"completionDateStruct":516,"leadSponsor":518,"locationsCount":519},{"fullName":5,"class":6},"Imagine Institute","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":10},"Patients",null,"Patients with genetically confirmed type I interferonopathy",[13],{"name":14,"role":15,"phone":16,"phoneExt":10,"email":17},"Marie-Louise FREMOND, Pr","CONTACT","01 44 49 48 24","marie-louise.fremond@institutimagine.org",[19,37,52,66,83,100,114,128,141,155,169,183,197,211,226,239,254,267,281,295,309,327,338,350,364,382,397,413,428,441,455,468],{"facility":20,"status":21,"city":22,"state":10,"zip":10,"country":23,"countryCode":24,"cosmosGeoPoint":25,"geoPoint":30,"contacts":31},"Medical University Innsbruck","NOT_YET_RECRUITING","Innsbruck","Austria","AT",{"type":26,"coordinates":27},"Point",[28,29],11.39454,47.26266,{"lat":29,"lon":28},[32,35],{"name":33,"role":15,"phone":10,"phoneExt":10,"email":34},"Philipp GAUCKLER, Dr","philipp.gauckler@i-med.ac.at",{"name":33,"role":36,"phone":10,"phoneExt":10,"email":10},"PRINCIPAL_INVESTIGATOR",{"facility":38,"status":21,"city":39,"state":10,"zip":10,"country":40,"countryCode":41,"cosmosGeoPoint":42,"geoPoint":46,"contacts":47},"Antwerp University Hospital","Antwerp","Belgium","BE",{"type":26,"coordinates":43},[44,45],4.40026,51.22047,{"lat":45,"lon":44},[48,51],{"name":49,"role":15,"phone":10,"phoneExt":10,"email":50},"Benson OGUNJIMI, Dr","benson.ogunjimi@uantwerpen.be",{"name":49,"role":36,"phone":10,"phoneExt":10,"email":10},{"facility":53,"status":21,"city":54,"state":10,"zip":10,"country":55,"countryCode":56,"cosmosGeoPoint":57,"geoPoint":61,"contacts":62},"Children's Hospital Zagreb","Zagreb","Croatia","HR",{"type":26,"coordinates":58},[59,60],15.97798,45.81444,{"lat":60,"lon":59},[63,65],{"name":64,"role":15,"phone":10,"phoneExt":10,"email":10},"Alenka GAGRO, Dr",{"name":64,"role":36,"phone":10,"phoneExt":10,"email":10},{"facility":67,"status":21,"city":68,"state":10,"zip":10,"country":69,"countryCode":10,"cosmosGeoPoint":70,"geoPoint":74,"contacts":75},"Motol University Hospital","Prague","Czechia",{"type":26,"coordinates":71},[72,73],14.42076,50.08804,{"lat":73,"lon":72},[76,79,80],{"name":77,"role":15,"phone":10,"phoneExt":10,"email":78},"Markéta BLOOMFIELD, Dr","marketa.bloomfield@fnmotol.cz",{"name":77,"role":36,"phone":10,"phoneExt":10,"email":10},{"name":81,"role":82,"phone":10,"phoneExt":10,"email":10},"Dita CEBECAUROVA, Dr","SUB_INVESTIGATOR",{"facility":84,"status":85,"city":86,"state":10,"zip":87,"country":88,"countryCode":89,"cosmosGeoPoint":90,"geoPoint":94,"contacts":95},"CHU d'Angers","RECRUITING","Angers","49000","France","FR",{"type":26,"coordinates":91},[92,93],-0.55202,47.47156,{"lat":93,"lon":92},[96,99],{"name":97,"role":15,"phone":10,"phoneExt":10,"email":98},"Coralie MALLEBRANCHE, Dr","coralie.mallebranche@chu-angers.fr",{"name":97,"role":36,"phone":10,"phoneExt":10,"email":10},{"facility":101,"status":85,"city":102,"state":10,"zip":103,"country":88,"countryCode":89,"cosmosGeoPoint":104,"geoPoint":108,"contacts":109},"Hôpital de Mercy - CHR Metz Thionville","Ars-Laquenexy","57530",{"type":26,"coordinates":105},[106,107],6.26989,49.09377,{"lat":107,"lon":106},[110,113],{"name":111,"role":15,"phone":10,"phoneExt":10,"email":112},"Anne-Charlotte CULLIER, Dr","Anne-Charlotte.cullier@chr-metz-thionville.fr",{"name":111,"role":36,"phone":10,"phoneExt":10,"email":10},{"facility":115,"status":85,"city":116,"state":10,"zip":117,"country":88,"countryCode":89,"cosmosGeoPoint":118,"geoPoint":122,"contacts":123},"CHU de Besançon","Besançon","25030",{"type":26,"coordinates":119},[120,121],6.01815,47.24878,{"lat":121,"lon":120},[124,127],{"name":125,"role":15,"phone":10,"phoneExt":10,"email":126},"Claire BALLOT-SCHMIT, Dr","cballotschmit@chu-besancon.fr",{"name":125,"role":36,"phone":10,"phoneExt":10,"email":10},{"facility":129,"status":21,"city":130,"state":10,"zip":10,"country":88,"countryCode":89,"cosmosGeoPoint":131,"geoPoint":135,"contacts":136},"CHU de Bordeaux","Bordeaux",{"type":26,"coordinates":132},[133,134],-0.58046,44.84124,{"lat":134,"lon":133},[137,140],{"name":138,"role":15,"phone":10,"phoneExt":10,"email":139},"Pascal PILLET, Dr","pascal.pillet@chu-bordeaux.fr",{"name":138,"role":36,"phone":10,"phoneExt":10,"email":10},{"facility":142,"status":85,"city":143,"state":10,"zip":144,"country":88,"countryCode":89,"cosmosGeoPoint":145,"geoPoint":149,"contacts":150},"CHU Morvan","Brest","29200",{"type":26,"coordinates":146},[147,148],-4.48628,48.39029,{"lat":148,"lon":147},[151,154],{"name":152,"role":15,"phone":10,"phoneExt":10,"email":153},"Elise SACAZE, Dr","elise.sacaze@chu-brest.fr",{"name":152,"role":36,"phone":10,"phoneExt":10,"email":10},{"facility":156,"status":85,"city":157,"state":10,"zip":158,"country":88,"countryCode":89,"cosmosGeoPoint":159,"geoPoint":163,"contacts":164},"Hôpital Femme Mère Enfant - HCL","Bron","69500",{"type":26,"coordinates":160},[161,162],4.91303,45.73865,{"lat":162,"lon":161},[165,168],{"name":166,"role":15,"phone":10,"phoneExt":10,"email":167},"Alexandre BELOT, Dr","alexandre.belot@chu-lyon.fr",{"name":166,"role":36,"phone":10,"phoneExt":10,"email":10},{"facility":170,"status":21,"city":171,"state":10,"zip":172,"country":88,"countryCode":89,"cosmosGeoPoint":173,"geoPoint":177,"contacts":178},"CHU de Dijon","Dijon","21231",{"type":26,"coordinates":174},[175,176],5.01391,47.31344,{"lat":176,"lon":175},[179,182],{"name":180,"role":15,"phone":10,"phoneExt":10,"email":181},"Mondher CHOUCHANE, Dr","mondher.chouchane@chu-dijon.fr",{"name":180,"role":36,"phone":10,"phoneExt":10,"email":10},{"facility":184,"status":85,"city":185,"state":10,"zip":186,"country":88,"countryCode":89,"cosmosGeoPoint":187,"geoPoint":191,"contacts":192},"Hôpitaux Nord Ouest Villefranche","Gleizé","69400",{"type":26,"coordinates":188},[189,190],4.69708,45.98916,{"lat":190,"lon":189},[193,196],{"name":194,"role":15,"phone":10,"phoneExt":10,"email":195},"Vanessa REMY PICCOLO, Dr","vremypiccolo@hno.fr",{"name":194,"role":36,"phone":10,"phoneExt":10,"email":10},{"facility":198,"status":21,"city":199,"state":10,"zip":200,"country":88,"countryCode":89,"cosmosGeoPoint":201,"geoPoint":205,"contacts":206},"Hôpital Bicêtre","Le Kremlin-Bicêtre","94270",{"type":26,"coordinates":202},[203,204],2.36073,48.81471,{"lat":204,"lon":203},[207,210],{"name":208,"role":15,"phone":10,"phoneExt":10,"email":209},"Kumaran DEIVA, Pr","kumaran.deiva@aphp.fr",{"name":208,"role":36,"phone":10,"phoneExt":10,"email":10},{"facility":212,"status":21,"city":213,"state":10,"zip":214,"country":88,"countryCode":89,"cosmosGeoPoint":215,"geoPoint":219,"contacts":220},"Hôpital Claude Huriez, CHU de Lille","Lille","59000",{"type":26,"coordinates":216},[217,218],3.05512,50.63391,{"lat":218,"lon":217},[221,225],{"name":222,"role":15,"phone":223,"phoneExt":10,"email":224},"Eric HACHULLA, Pr","03 20 44 56 50","eric.hachulla@chu-lille.fr",{"name":222,"role":36,"phone":10,"phoneExt":10,"email":10},{"facility":227,"status":85,"city":228,"state":10,"zip":10,"country":88,"countryCode":89,"cosmosGeoPoint":229,"geoPoint":233,"contacts":234},"APHM Hôpitaux de Marseille","Marseille",{"type":26,"coordinates":230},[231,232],5.38107,43.29695,{"lat":232,"lon":231},[235,238],{"name":236,"role":15,"phone":10,"phoneExt":10,"email":237},"Anne-Laure JURQUET, Dr","anne-laure.jurquet@ap-hm.fr",{"name":236,"role":36,"phone":10,"phoneExt":10,"email":10},{"facility":240,"status":85,"city":241,"state":10,"zip":242,"country":88,"countryCode":89,"cosmosGeoPoint":243,"geoPoint":247,"contacts":248},"CHU de Montpellier","Montpellier","34295",{"type":26,"coordinates":244},[245,246],3.87635,43.61093,{"lat":246,"lon":245},[249,252],{"name":250,"role":15,"phone":10,"phoneExt":10,"email":251},"Aurélia CARBASSE, Dr","a-carbasse@chu-montpellier.fr",{"name":253,"role":36,"phone":10,"phoneExt":10,"email":10},"Aurélia a-carbasse@chu-montpellier.fr, Dr",{"facility":255,"status":85,"city":256,"state":10,"zip":10,"country":88,"countryCode":89,"cosmosGeoPoint":257,"geoPoint":261,"contacts":262},"CHRU Nancy","Nancy",{"type":26,"coordinates":258},[259,260],6.18496,48.68439,{"lat":260,"lon":259},[263,266],{"name":264,"role":15,"phone":10,"phoneExt":10,"email":265},"Anne MIRGUET, Dr","A.mirguet@chru-nancy.fr",{"name":264,"role":36,"phone":10,"phoneExt":10,"email":10},{"facility":268,"status":85,"city":269,"state":10,"zip":270,"country":88,"countryCode":89,"cosmosGeoPoint":271,"geoPoint":275,"contacts":276},"CHU de Nantes","Nantes","44000",{"type":26,"coordinates":272},[273,274],-1.55336,47.21725,{"lat":274,"lon":273},[277,280],{"name":278,"role":15,"phone":10,"phoneExt":10,"email":279},"Elsa LORINO, Dr","elsa.lorino@chu-nantes.fr",{"name":278,"role":36,"phone":10,"phoneExt":10,"email":10},{"facility":282,"status":85,"city":283,"state":10,"zip":284,"country":88,"countryCode":89,"cosmosGeoPoint":285,"geoPoint":289,"contacts":290},"CH Agen-Nérac","Nérac","47600",{"type":26,"coordinates":286},[287,288],0.33844,44.13597,{"lat":288,"lon":287},[291,294],{"name":292,"role":15,"phone":10,"phoneExt":10,"email":293},"Mélanie RORIZ, Dr","rorizm@ch-agen-nerac.fr",{"name":292,"role":36,"phone":10,"phoneExt":10,"email":10},{"facility":296,"status":85,"city":297,"state":10,"zip":298,"country":88,"countryCode":89,"cosmosGeoPoint":299,"geoPoint":303,"contacts":304},"Hôpital de l'Archet","Nice","06200",{"type":26,"coordinates":300},[301,302],7.26608,43.70313,{"lat":302,"lon":301},[305,308],{"name":306,"role":15,"phone":10,"phoneExt":10,"email":307},"Julie BERNARDOR, Dr","bernardor.j@chu-nice.fr",{"name":306,"role":36,"phone":10,"phoneExt":10,"email":10},{"facility":310,"status":21,"city":311,"state":10,"zip":312,"country":88,"countryCode":89,"cosmosGeoPoint":313,"geoPoint":317,"contacts":318},"Hôpital Armand Trousseau","Paris","75012",{"type":26,"coordinates":314},[315,316],2.3488,48.85341,{"lat":316,"lon":315},[319,322,323,325],{"name":320,"role":15,"phone":10,"phoneExt":10,"email":321},"Isabelle MELKI, Dr","isabelle.melki@aphp.fr",{"name":320,"role":36,"phone":10,"phoneExt":10,"email":10},{"name":324,"role":82,"phone":10,"phoneExt":10,"email":10},"Nadia NATHAN, Dr",{"name":326,"role":82,"phone":10,"phoneExt":10,"email":10},"Florence RENALDO, Dr",{"facility":328,"status":21,"city":311,"state":10,"zip":329,"country":88,"countryCode":89,"cosmosGeoPoint":330,"geoPoint":332,"contacts":333},"Hôpital Bichat","75018",{"type":26,"coordinates":331},[315,316],{"lat":316,"lon":315},[334,337],{"name":335,"role":15,"phone":10,"phoneExt":10,"email":336},"Clémence DAVID, Dr","clemence.david3@aphp.fr",{"name":335,"role":36,"phone":10,"phoneExt":10,"email":10},{"facility":339,"status":21,"city":311,"state":10,"zip":340,"country":88,"countryCode":89,"cosmosGeoPoint":341,"geoPoint":343,"contacts":344},"Hôpital Robert Debré","75019",{"type":26,"coordinates":342},[315,316],{"lat":316,"lon":315},[345,348],{"name":346,"role":15,"phone":10,"phoneExt":10,"email":347},"Ulrich MEINZER, Dr","ulrich.meinzer@aphp.fr",{"name":349,"role":36,"phone":10,"phoneExt":10,"email":10},"Ulric MEINZER, Dr",{"facility":351,"status":85,"city":352,"state":10,"zip":353,"country":88,"countryCode":89,"cosmosGeoPoint":354,"geoPoint":358,"contacts":359},"Hôpital des Enfants - CHU de Toulouse","Toulouse","31300",{"type":26,"coordinates":355},[356,357],1.44367,43.60426,{"lat":357,"lon":356},[360,363],{"name":361,"role":15,"phone":10,"phoneExt":10,"email":362},"Léa RODITIS, Dr","roditis.l@chu-toulouse.Fr",{"name":361,"role":36,"phone":10,"phoneExt":10,"email":10},{"facility":365,"status":85,"city":311,"state":366,"zip":367,"country":88,"countryCode":89,"cosmosGeoPoint":368,"geoPoint":370,"contacts":371},"Hôpital Necker Enfants Malades","Île-de-France Region","75015",{"type":26,"coordinates":369},[315,316],{"lat":316,"lon":315},[372,373,374,376,378,380],{"name":14,"role":15,"phone":10,"phoneExt":10,"email":17},{"name":14,"role":36,"phone":10,"phoneExt":10,"email":10},{"name":375,"role":82,"phone":10,"phoneExt":10,"email":10},"Anne WELFRINGER, Dr",{"name":377,"role":82,"phone":10,"phoneExt":10,"email":10},"Bénédicte NEVEN, Pr",{"name":379,"role":82,"phone":10,"phoneExt":10,"email":10},"Marie HULLY, Dr",{"name":381,"role":82,"phone":10,"phoneExt":10,"email":10},"Alice HADCHOUEL, Pr",{"facility":383,"status":21,"city":384,"state":10,"zip":10,"country":385,"countryCode":386,"cosmosGeoPoint":387,"geoPoint":391,"contacts":392},"University of Tübingen","Tübingen","Germany","DE",{"type":26,"coordinates":388},[389,390],9.05222,48.52266,{"lat":390,"lon":389},[393,395],{"name":394,"role":15,"phone":10,"phoneExt":10,"email":10},"Özlem SATIRER",{"name":396,"role":36,"phone":10,"phoneExt":10,"email":10},"Özlem SATIRER, Dr",{"facility":398,"status":21,"city":399,"state":10,"zip":10,"country":400,"countryCode":401,"cosmosGeoPoint":402,"geoPoint":406,"contacts":407},"Meyer Children's Hospital IRCCS","Florence","Italy","IT",{"type":26,"coordinates":403},[404,405],11.24626,43.77925,{"lat":405,"lon":404},[408,411],{"name":409,"role":15,"phone":10,"phoneExt":10,"email":410},"Lorenzo LODI","lorenzo.lodi@meyer.it",{"name":412,"role":36,"phone":10,"phoneExt":10,"email":10},"Lorenzo LODI, Dr",{"facility":414,"status":21,"city":415,"state":10,"zip":10,"country":416,"countryCode":417,"cosmosGeoPoint":418,"geoPoint":422,"contacts":423},"Hospital Universitari Vall d'Hebron","Barcelona","Spain","ES",{"type":26,"coordinates":419},[420,421],2.15899,41.38879,{"lat":421,"lon":420},[424,427],{"name":425,"role":15,"phone":10,"phoneExt":10,"email":426},"Jacques RIVIERE, Dr","jacques.riviere@vallhebron.cat",{"name":425,"role":36,"phone":10,"phoneExt":10,"email":10},{"facility":429,"status":21,"city":430,"state":10,"zip":10,"country":416,"countryCode":417,"cosmosGeoPoint":431,"geoPoint":435,"contacts":436},"Hospital Universitario Son Espases","Palma de Mallorca",{"type":26,"coordinates":432},[433,434],2.65024,39.56939,{"lat":434,"lon":433},[437,440],{"name":438,"role":15,"phone":10,"phoneExt":10,"email":439},"Jan RAMAKERS, Dr","jan.ramakers@ssib.es",{"name":438,"role":36,"phone":10,"phoneExt":10,"email":10},{"facility":442,"status":21,"city":443,"state":10,"zip":10,"country":444,"countryCode":445,"cosmosGeoPoint":446,"geoPoint":450,"contacts":451},"Karolinska University Hospital","Stockholm","Sweden","SE",{"type":26,"coordinates":447},[448,449],18.06871,59.32938,{"lat":449,"lon":448},[452],{"name":453,"role":15,"phone":10,"phoneExt":10,"email":454},"Petter BRODIN, Dr","petter.brodin@ki.se",{"facility":456,"status":85,"city":457,"state":10,"zip":10,"country":458,"countryCode":10,"cosmosGeoPoint":459,"geoPoint":463,"contacts":464},"Hacettepe İhsan Doğramacı Children's Hospital","Ankara","Turkey (Türkiye)",{"type":26,"coordinates":460},[461,462],32.85427,39.91987,{"lat":462,"lon":461},[465],{"name":466,"role":15,"phone":10,"phoneExt":10,"email":467},"Seza Özen, Pr","sezaozen@hacettepe.edu.tr",{"facility":469,"status":21,"city":470,"state":10,"zip":10,"country":471,"countryCode":472,"cosmosGeoPoint":473,"geoPoint":477,"contacts":478},"Leeds Teaching Hospitals NHS Trust","Leeds","United Kingdom","UK",{"type":26,"coordinates":474},[475,476],-1.54785,53.79648,{"lat":476,"lon":475},[479,482],{"name":480,"role":15,"phone":10,"phoneExt":10,"email":481},"Jade-Lauren BELTON, Dr","jade-lauren.belton@nhs.net",{"name":480,"role":36,"phone":10,"phoneExt":10,"email":10},{"type":484,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100596078","natural-history-of-type-1-interferonopathies-insights-from-a-european-cohort-100596078",false,"NCT07040774","Natural History of Type 1 Interferonopathies: Insights From a European Cohort","EU-IFNp","Inclusion Criteria:\n\n* Genetically confirmed patient with type I interferonopathy\n* Patient affiliated to a social security scheme or beneficiary of such a scheme.\n\nExclusion Criteria:\n\n\\- Opposition of the patient and\u002For parental authority if the patient is a minor, to participation in the study.","ALL",{"count":494,"type":495},500,"ESTIMATED","OBSERVATIONAL","Type I interferonopathies are rare autoinflammatory disorders caused by genetic defects and associated with significant morbidity and mortality. These diseases are refractory to conventional immunosuppressive therapies. They typically occur in childhood, although disease onset in adulthood has been observed. The clinical spectrum is wide and mainly involves the central nervous system. Joint involvement is also common, and more rarely, haematological features such as cytopenias or immunodeficiency may be observed.\n\nNearly all patients show consistent over-activation of the type I IFN pathway, as evidenced, the expression of IFN-stimulated genes, the so-called 'interferon signature'. To date, the natural history of interferonopathies remains unclear.\n\nIn this context, the establishment of a natural history of type I interferonopathy in patients is proposed to elucidate the pathophysiological mechanisms and identify biomarkers for diagnosis, prognosis, and disease activity, with the aim of better characterising the diversity of interferonopathies.\n\nThe main objective is to characterise the evolution of the pathology in paediatric and adult patients with type I interferonopathies.\n\nThe overall aim of this research is to propose therapeutic options tailored to patient phenotypes and to better define patient sub-groups in order to optimise the preparation of future clinical trials.",[499,500,501,502],"Genetic Disease","Immune Dysfunction","Neurological Diseases or Conditions","Autoimmune Diseases",[504,505,506,507,508,509],"Immune dysfuntion","Neurological disease","Autoimmune diseases","Genetics diseases","Interferon","Aicardi-Goutieres Syndrom","2026-05-12",{"date":512,"type":513},"2026-05-13","ACTUAL",{"date":515,"type":513},"2025-10-01",{"date":517,"type":495},"2045-10",{"name":5,"class":6},32]