[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100544917":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":12,"centralContacts":17,"locations":26,"responsibleParty":46,"collaborators":10,"id":48,"slug":49,"hasResults":50,"nctId":51,"briefTitle":52,"officialTitle":52,"acronym":10,"eligibilityCriteria":53,"healthyVolunteers":50,"sex":54,"minAge":55,"maxAge":56,"enrollmentInfo":57,"targetDuration":10,"studyType":60,"phases":10,"briefSummary":61,"conditions":62,"keywords":65,"overallStatus":29,"whyStopped":10,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":77},{"fullName":5,"class":6},"National Institutes of Health Clinical Center (CC)","NIH",[8],{"label":9,"type":10,"description":11,"interventionNames":10},"Cohort 1",null,"Participants with Kaposi sarcoma",[13],{"name":14,"affiliation":15,"role":16},"Ramya M Ramaswami, M.D.","National Cancer Institute (NCI)","PRINCIPAL_INVESTIGATOR",[18,23],{"name":19,"role":20,"phone":21,"phoneExt":10,"email":22},"Irene B Ekwede, R.N.","CONTACT","(240) 760-6126","irene.ekwede@nih.gov",{"name":14,"role":20,"phone":24,"phoneExt":10,"email":25},"(240) 506-1088","ramya.ramaswami@nih.gov",[27],{"facility":28,"status":29,"city":30,"state":31,"zip":32,"country":33,"countryCode":34,"cosmosGeoPoint":35,"geoPoint":40,"contacts":41},"National Institutes of Health Clinical Center","RECRUITING","Bethesda","Maryland","20892","United States","US",{"type":36,"coordinates":37},"Point",[38,39],-77.10026,38.98067,{"lat":39,"lon":38},[42],{"name":43,"role":20,"phone":44,"phoneExt":10,"email":45},"National Cancer Institute Referral Office","888-624-1937","ncimo_referrals@mail.nih.gov",{"type":47,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100544917","natural-history-study-of-kaposi-sarcoma-100544917",false,"NCT06375122","Natural History Study of Kaposi Sarcoma","* INCLUSION CRITERIA:\n\nParticipants must have histological KS confirmed by the Laboratory of Pathology (LP), NCI.\n\n* KS as assessed by cutaneous or oral KS lesions or other assessable KS disease.\n* Age \\>=18 years.\n* ECOG performance status \\\u003C=4.\n* Ability of participant to understand and the willingness to sign a written informed consent document.\n\nEXCLUSION CRITERIA:\n\n* Participants with active KSHV-associated inflammatory cytokine syndrome (KICS), multicentric Castleman disease (MCD), or primary effusion lymphoma (PEL).\n* Participants with serious and\u002For uncontrolled severe intercurrent illness, such as opportunistic infections, that in the judgement of the investigator would preclude participation in the study.","ALL","18 Years","120 Years",{"count":58,"type":59},150,"ESTIMATED","OBSERVATIONAL","Background:\n\nKaposi sarcoma (KS) is a type of tumor caused by the Kaposi sarcoma herpesvirus. KS usually affects the skin, but lesions can also appear in the lymph nodes, lungs and digestive tract. KS is most common in people with compromised immunity, but it also appears in otherwise healthy people. Researchers want to understand more about how KS develops, why it may recur, and how it affects the immune system and organs.\n\nObjective:\n\nTo learn more about the natural history of KS.\n\nEligibility:\n\nPeople aged 18 years and older with KS.\n\nDesign:\n\nParticipants will be screened. They will have a physical exam with blood tests. They will have an imaging scan. They may need a new biopsy: Tissue samples may be cut from their tumor. Their ability to perform normal activities will be assessed.\n\nParticipants will visit the clinic to have their KS evaluated. In addition to the imaging scans and other tests performed during screening, procedures may include:\n\nEye exam.\n\nUltrasound exam of the heart (electrocardiogram).\n\nCollection of saliva and urine samples.\n\nBiopsies of the skin or lymph nodes.\n\nSwabs of the anus and cervix.\n\nPhotographs of skin lesions.\n\nRemoval of fluid samples from the space around the lungs, intestine, or heart.\n\nThe evaluation visit will be repeated 5 more times over 18 months and then yearly for up to 10 years.\n\nParticipants will follow their standard treatment for KS during the study.",[63,64],"Kaposi Sarcoma","HIV",[63,66,67],"Samples and data collection","Longitudinal clinical evaluations","2026-05-29",{"date":70,"type":71},"2026-06-01","ACTUAL",{"date":73,"type":71},"2024-05-15",{"date":75,"type":59},"2036-12-31",{"name":15,"class":6},1]