[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100333672":3},{"organization":4,"armGroups":7,"interventions":7,"overallOfficials":8,"centralContacts":13,"locations":24,"responsibleParty":46,"collaborators":7,"id":48,"slug":49,"hasResults":50,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":7,"eligibilityCriteria":54,"healthyVolunteers":50,"sex":55,"minAge":7,"maxAge":7,"enrollmentInfo":56,"targetDuration":7,"studyType":59,"phases":7,"briefSummary":60,"conditions":61,"keywords":68,"overallStatus":27,"whyStopped":7,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":83},{"fullName":5,"class":6},"Hugo W. Moser Research Institute at Kennedy Krieger, Inc.","OTHER",null,[9],{"name":10,"affiliation":11,"role":12},"Amena S Fine, MD PhD","Moser Center for Leukodystrophies at Kennedy Krieger Institute","PRINCIPAL_INVESTIGATOR",[14,20],{"name":15,"role":16,"phone":17,"phoneExt":18,"email":19},"Aditii Makwana, MS","CONTACT","667-205-4498","4498","makwana@kennedykrieger.org",{"name":21,"role":16,"phone":22,"phoneExt":7,"email":23},"Jordan Goodman, MS","443-923-2769","goodmanj@kennedykrieger.org",[25],{"facility":26,"status":27,"city":28,"state":29,"zip":30,"country":31,"countryCode":32,"cosmosGeoPoint":33,"geoPoint":38,"contacts":39},"Hugo Moser Center for Leukodystrophies","RECRUITING","Baltimore","Maryland","21205","United States","US",{"type":34,"coordinates":35},"Point",[36,37],-76.61219,39.29038,{"lat":37,"lon":36},[40,44],{"name":41,"role":16,"phone":42,"phoneExt":7,"email":43},"Connor Murray","443-923-2750","murrayc@kennedykrieger.org",{"name":45,"role":12,"phone":7,"phoneExt":7,"email":7},"Ali Fatemi, MD MBA",{"type":47,"investigatorFullName":7,"investigatorTitle":7,"investigatorAffiliation":7,"oldNameTitle":7,"oldOrganization":7},"SPONSOR","100333672","natural-history-study-of-leukoencephalopathy-with-brainstem-and-spinal-cord-involvement-and-lactate-elevation-lbsl-100333672",false,"NCT03624374","Natural History Study of Leukoencephalopathy With Brainstem and Spinal Cord Involvement and Lactate Elevation (LBSL)","Characterization of the Natural History of Leukoencephalopathy With Brainstem and Spinal Cord Involvement and Lactate Elevation","Inclusion Criteria:\n\n1. Confirmed DARS2 mutation through genetic analysis\n2. Ability of the caregiver or participant to speak and understand English at an 8th-grade level\n\nExclusion Criteria:\n\n* The vulnerable populations of prisoners, non-viable neonates, pregnant women, adults lacking the capacity to consent, non-English speakers or children who are in foster care or wards of the state.","ALL",{"count":57,"type":58},100,"ESTIMATED","OBSERVATIONAL","In this study, we will conduct retrospective chart and imaging reviews and prospective longitudinal virtual assessments of individuals with LBSL.",[62,63,64,65,66,67],"Leukoencephalopathies","LBSL","Leukoencephalopathy With Brainstem and Spinal Cord Involvement and Lactate Elevation","White Matter Disease","Ataxia, Cerebellar","Genetic Disease",[69,70,71,72,73],"Natural History Study","Kennedy Krieger Institute","Virtual assessment","DARS2","Johns Hopkins Hospital","2024-07-01",{"date":76,"type":77},"2024-07-03","ACTUAL",{"date":79,"type":77},"2018-04-01",{"date":81,"type":58},"2029-05",{"name":5,"class":6},1]