[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100578010":3},{"organization":4,"armGroups":7,"interventions":7,"overallOfficials":7,"centralContacts":7,"locations":8,"responsibleParty":32,"collaborators":34,"id":39,"slug":40,"hasResults":41,"nctId":42,"briefTitle":43,"officialTitle":44,"acronym":45,"eligibilityCriteria":46,"healthyVolunteers":41,"sex":47,"minAge":7,"maxAge":48,"enrollmentInfo":49,"targetDuration":7,"studyType":52,"phases":7,"briefSummary":53,"conditions":54,"keywords":56,"overallStatus":11,"whyStopped":7,"lastUpdateSubmitDate":59,"lastUpdatePostDateStruct":60,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":68},{"fullName":5,"class":6},"Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta","OTHER",null,[9],{"facility":10,"status":11,"city":12,"state":7,"zip":13,"country":14,"countryCode":15,"cosmosGeoPoint":16,"geoPoint":21,"contacts":22},"Fondazione IRCCS Istituto Neurologico Carlo Besta","RECRUITING","Milan","20133","Italy","IT",{"type":17,"coordinates":18},"Point",[19,20],12.59836,42.78235,{"lat":20,"lon":19},[23,28,30],{"name":24,"role":25,"phone":26,"phoneExt":7,"email":27},"Stefano D'Arrigo, MD","CONTACT","02.2394.2210","stefano.darrigo@istituto-besta.it",{"name":29,"role":25,"phone":7,"phoneExt":7,"email":7},"Claudia Ciaccio, MD",{"name":29,"role":31,"phone":7,"phoneExt":7,"email":7},"PRINCIPAL_INVESTIGATOR",{"type":33,"investigatorFullName":7,"investigatorTitle":7,"investigatorAffiliation":7,"oldNameTitle":7,"oldOrganization":7},"SPONSOR",[35,37],{"name":36,"class":6},"Azienda Ospedaliera Sant'Anna",{"name":38,"class":6},"Fondazione Policlinico Universitario Agostino Gemelli IRCCS","100578010","natural-history-with-focus-on-oncological-risk-evaluation-in-pediatric-patients-with-pten-pathogenic-variants-100578010",false,"NCT06805734","Natural History With Focus on Oncological Risk Evaluation in Pediatric Patients With PTEN Pathogenic Variants","Natural History With Focus on Oncological Risk Evaluation in Pediatric Patients With PTEN Pathogenic Variants - Observational Study","PTEN_Ped","Inclusion Criteria:\n\n* PTEN pathogenic variants (class 4\u002F5 SNV, gene deletion, intragenic duplication\u002Fdeletion)\n* Pediatric patients (\\\u003C18 years old) and their affected relatives, male\u002Ffemale, all ethnicities\n* The legal representative must agree to follow the screening protocol\n* Informed consent signed by the legal representative\n\nExclusion Criteria:\n\n* Refuse to undergo the exams of the protocol assessment at the diagnosis\n* PTEN non-pathogenic variants (VOUS or benign\u002Flikely benign vatiants)\n* No signed informed consent","ALL","17 Years",{"count":50,"type":51},50,"ESTIMATED","OBSERVATIONAL","This is an observational study in pediatric patientis carryng PTEN pathogenic variants aimed to define oncological risk in children and provide a deeper insight of the clinical course, establishing an updated follow-up protocol.",[55],"PTEN Hamartoma Syndrome",[57,58],"PTEN","PTHS","2026-02-10",{"date":61,"type":62},"2026-02-12","ACTUAL",{"date":64,"type":62},"2024-08-01",{"date":66,"type":51},"2029-07",{"name":5,"class":6},1]