[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100528925":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":29,"locations":39,"responsibleParty":60,"collaborators":18,"id":63,"slug":64,"hasResults":65,"nctId":66,"briefTitle":67,"officialTitle":68,"acronym":18,"eligibilityCriteria":69,"healthyVolunteers":65,"sex":70,"minAge":71,"maxAge":18,"enrollmentInfo":72,"targetDuration":18,"studyType":75,"phases":76,"briefSummary":78,"conditions":79,"keywords":18,"overallStatus":41,"whyStopped":18,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":90},{"fullName":5,"class":6},"Chongqing University Cancer Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Optimized CTV","EXPERIMENTAL","The contralateral CTV1 was defined as a subclinical disease consisting of 5mm margin surrounding GTVnx.The CTV2 was defined as potentially involved regions consisting of 5mm margin surrounding CTV1, and contralateral CTV2 only included the pharyngeal recess.",[13],"Radiation: CTV optimized IMRT",{"label":15,"type":16,"description":17,"interventionNames":18},"Conventional CTV","NO_INTERVENTION","The CTV1 was defined as GTVnx + 5 mm + entire nasopharynx mucosa .The CTV2 was defined as GTV1+ 5 mm + corresponding anatomical structures.",null,[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":18},"RADIATION","CTV optimized IMRT","The contralateral CTV1 was defined as a subclinical disease consisting of 5mm margin surrounding GTVnx.The CTV2 was defined as a potentially involved regions consisting of 5mm margin surrounding CTV1, and contralateral CTV2 only included the pharyngeal recess.",[9],[26],{"name":27,"affiliation":5,"role":28},"Ying Wang, Ph.D, M.D.","PRINCIPAL_INVESTIGATOR",[30,35],{"name":31,"role":32,"phone":33,"phoneExt":18,"email":34},"Yuwei Wang, M.M.","CONTACT","13436161758","38664816@qq.com",{"name":36,"role":32,"phone":37,"phoneExt":18,"email":38},"Ying Wang, Ph.D,M.D.","13996412826","yingwang197011@163.com",[40],{"facility":5,"status":41,"city":42,"state":43,"zip":44,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"RECRUITING","Chongqing","Chongqing Municipality","400030","China","CN",{"type":48,"coordinates":49},"Point",[50,51],106.55771,29.56026,{"lat":51,"lon":50},[54,55,57,58],{"name":31,"role":32,"phone":33,"phoneExt":18,"email":34},{"name":56,"role":32,"phone":37,"phoneExt":18,"email":38},"Ying Wang, Ph.D, M. D.",{"name":56,"role":28,"phone":18,"phoneExt":18,"email":18},{"name":31,"role":59,"phone":18,"phoneExt":18,"email":18},"SUB_INVESTIGATOR",{"type":28,"investigatorFullName":61,"investigatorTitle":62,"investigatorAffiliation":5,"oldNameTitle":18,"oldOrganization":18},"Ying Wang","Associate Director of Chongqing University Cancer Hospital","100528925","nbi-combined-with-mri-to-guide-ctv-optimization-in-eccentric-nasopharyngeal-carcinoma-100528925",false,"NCT06167109","NBI Combined With MRI to Guide CTV Optimization in Eccentric Nasopharyngeal Carcinoma","Endoscopic NBI Combined With MRI to Guide the Optimization of Clinical Target Volume Delineation in Eccentric Nasopharyngeal Carcinoma","Inclusion Criteria:\n\n1. Males and females ≥18 years of age;\n2. ECOG Performance Status 0,1 or 2;\n3. Pathologically diagnosed as nasopharyngeal carcinoma;\n4. Pretreatment nasopharynx and neck MRI imaging;\n5. Nasopharyngeal suspected lesions were examined by NBI endoscopy;\n6. Meeting the definition of eccentric NPC with ipsilateral (affected side) staging of T1-4 and contralateral (healthy side) staging of T0;\n7. Patients evaluated without contraindications to radiotherapy;\n8. Voluntary participation in clinical research, and signed informed consent.\n\nExclusion Criteria:\n\n1. Patients who did not successfully undergo all three examinations (MRI, NBI, and endoscopic biopsy);\n2. Other rare pathological types, such as adenocarcinoma;\n3. Patients with tumor invasion of the clivus;\n4. Patients whose contralateral retropharyngeal lymph nodes met the diagnostic criteria;\n5. Invasion of paranasal sinuses (except simple sphenoid invasion).","ALL","18 Years",{"count":73,"type":74},60,"ESTIMATED","INTERVENTIONAL",[77],"NA","This is a prospective, single-center clinical trial in eccentric nasopharyngeal carcinoma (NPC) patients. The aim of this study is to evaluate the efficacy and safety of NBI combined with MRI-guided optimized CTV compared with conventional CTV, and to compare the radiotherapy-related adverse events and quality of life between the two groups.",[80],"Nasopharyngeal Carcinoma by AJCC V8 Stage","2023-12-04",{"date":83,"type":84},"2023-12-12","ACTUAL",{"date":86,"type":84},"2023-10-20",{"date":88,"type":74},"2026-10",{"name":5,"class":6},1]