[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100509532":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":30,"centralContacts":34,"locations":41,"responsibleParty":62,"collaborators":25,"id":64,"slug":65,"hasResults":66,"nctId":67,"briefTitle":68,"officialTitle":69,"acronym":25,"eligibilityCriteria":70,"healthyVolunteers":71,"sex":72,"minAge":73,"maxAge":74,"enrollmentInfo":75,"targetDuration":25,"studyType":78,"phases":79,"briefSummary":81,"conditions":82,"keywords":85,"overallStatus":43,"whyStopped":25,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":99},{"fullName":5,"class":6},"University of Calgary","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"999 mL normal Saline","EXPERIMENTAL","999 mL of normal saline infused intravenously.",[13],"Other: IV normal saline (999 mL infusion)",{"label":15,"type":16,"description":17,"interventionNames":18},"50 mL normal Saline","PLACEBO_COMPARATOR","50 mL of normal saline infused intravenously.",[19],"Other: IV normal saline (50 mL infusion)",[21,26],{"type":6,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"IV normal saline (999 mL infusion)","999 mL of IV normal saline will be infused intravenously",[9],null,{"type":6,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"IV normal saline (50 mL infusion)","50 mL of IV normal saline will be infused intravenously as a placebo control.",[15],[31],{"name":32,"affiliation":5,"role":33},"Satish R Raj, MD MSCI","PRINCIPAL_INVESTIGATOR",[35,39],{"name":32,"role":36,"phone":37,"phoneExt":25,"email":38},"CONTACT","(403)210-6152","autonomic.research@ucalgary.ca",{"name":40,"role":36,"phone":25,"phoneExt":25,"email":38},"Rasha Hamzeh, RN",[42],{"facility":5,"status":43,"city":44,"state":45,"zip":46,"country":47,"countryCode":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":55},"RECRUITING","Calgary","Alberta","T2N 4Z6","Canada","CA",{"type":50,"coordinates":51},"Point",[52,53],-114.08529,51.05011,{"lat":53,"lon":52},[56,59],{"name":57,"role":36,"phone":58,"phoneExt":25,"email":38},"Satish R Raj, MD, MSCI","403-210-6152",{"name":60,"role":36,"phone":61,"phoneExt":25,"email":38},"Robert S Sheldon, MD, PhD","403-220-8191",{"type":63,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR","100509532","nc-testing-in-lc--pots-100509532",false,"NCT05914649","NC Testing in LC & POTS","Neurocognitive Testing in Long COVID and Postural Tachycardia Syndrome Patients With Normal Saline: A Pilot Study","Inclusion Criteria:\n\n* Patients with diagnosis of Long COVID\n* SARS-COV2 test positive\n* Symptoms \\> 12 weeks post COVID\n* Subjective complaint of 'brain fog\" or cognitive dysfunction\n* Patients with diagnosis of Postural Orthostatic Syndrome (POTS) from the Calgary Autonomic Investigation and Management Clinic\n* Subjective complaint of 'brain fog\" or cognitive impairment\n* Healthy participants\n* Without POTS or \"brain fog\"\n* Age 18 to 60 years\n* Female and Male\n* Able to give an informed consent\n\nExclusion Criteria:\n\n* Patients with overt causes for POTS (e.g., dehydration, prolonged bed rest)\n* An inability to safely withdraw from medicine(s) that could make test interpretation difficult and impossible.\n* Other factors which are in the investigator's opinion would prevent the participant from completing the protocol, including poor compliance during previous studies or an unpredictable schedule.\n* Unable to give an informed consent.",true,"ALL","18 Years","60 Years",{"count":76,"type":77},100,"ESTIMATED","INTERVENTIONAL",[80],"NA","Patients with Postural Orthostatic Tachycardia Syndrome (POTS) and Post-Acute Sequelae of COVID (PASC, or \"Long COVID\") experience cognitive dysfunction. The investigators will test the hypothesis that 999 mL of IV saline will improve cognitive function in patients with POTS and Long COVID compared to placebo (50 mL of saline).",[83,84],"Postural Orthostatic Tachycardia Syndrome","Post Acute Sequelae of SARS CoV 2 Infection",[86,87,88,89],"POTS","Long COVID","Cognitive","Brain Fog","2026-04-30",{"date":92,"type":93},"2026-05-07","ACTUAL",{"date":95,"type":93},"2024-09-19",{"date":97,"type":77},"2030-12-31",{"name":5,"class":6},1]