[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100569178":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":24,"centralContacts":32,"locations":42,"responsibleParty":62,"collaborators":64,"id":70,"slug":71,"hasResults":72,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":10,"eligibilityCriteria":76,"healthyVolunteers":77,"sex":78,"minAge":79,"maxAge":80,"enrollmentInfo":81,"targetDuration":10,"studyType":84,"phases":10,"briefSummary":85,"conditions":86,"keywords":89,"overallStatus":45,"whyStopped":10,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":102},{"fullName":5,"class":6},"International Research Training Group 2804","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Pre-pubertal girls (children)",null,"8-10 years of girls having pubertal stage 1",[13],"Behavioral: Stress",{"label":15,"type":10,"description":16,"interventionNames":17},"Post-pubertal girls (adolescents)","15-17 years of girls having pubertal stage 5",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":10},"BEHAVIORAL","Stress","Montreal Imaging Stress Task is a stress paradigm in the scanner to examine neuronal correlates of acute psychosocial stress.",[15,9],[25,29],{"name":26,"affiliation":27,"role":28},"Vanessa Nieratschker, Prof.","University Hospital Tuebingen","PRINCIPAL_INVESTIGATOR",{"name":30,"affiliation":27,"role":31},"Mirac Nur Musaoglu, MD","STUDY_DIRECTOR",[33,38],{"name":34,"role":35,"phone":36,"phoneExt":10,"email":37},"Vanessa Nieratschker, Prof. Dr.","CONTACT","+497071-2985523","vanessa.nieratschker@med.uni-tuebingen.de",{"name":39,"role":35,"phone":40,"phoneExt":10,"email":41},"Birgit Derntl, Prof. Dr.","+497071 29-85437","birgit.derntl@med.uni-tuebingen.de",[43],{"facility":44,"status":45,"city":46,"state":47,"zip":48,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"University of Tuebingen; Department of Psychiatry & Psychotherapy; Tuebingen","RECRUITING","Tübingen","Baden-Wurttemberg","72076","Germany","DE",{"type":52,"coordinates":53},"Point",[54,55],9.05222,48.52266,{"lat":55,"lon":54},[58,60,61],{"name":34,"role":35,"phone":59,"phoneExt":10,"email":37},"+497071 29-85523",{"name":30,"role":35,"phone":10,"phoneExt":10,"email":10},{"name":34,"role":35,"phone":10,"phoneExt":10,"email":10},{"type":63,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[65,66,68],{"name":27,"class":6},{"name":67,"class":6},"Uppsala University",{"name":69,"class":6},"German Research Foundation","100569178","negative-emotionality-and-epigenetics-during-puberty-100569178",false,"NCT06690866","Negative Emotionality and Epigenetics During Puberty","Negative Emotionality in Relation to Epigenetics of Estrogen Signaling During Puberty","Inclusion Criteria:\n\n* healthy girls\n* aged between 8-10 and having pubertal stage 1 or between 15-17 and having pubertal stage 5\n* normal body mass index according to age (between 5th and 85th percentile)\n* non-smoking\n* German language fluency\n* Attending age-appropriate schools\n\nExclusion Criteria:\n\n* neurological or psychiatric disease\n* medical problems such as hormonal, metabolic, developmental or chronic diseases (e.g., congenital disorders, precocious puberty, polycystic ovarian syndrome, diabetes or congestive heart failure)\n* any kind of hormonal, pharmacological or psychotropic treatment in the last three months\n* engaging in competitive\u002Fextreme sports\n\nAdditional exclusion criteria for MRI:\n\n* People with non-removable metal objects on or in the body\n* Tattoos (if not MRI-incompatible according to expert guidelines)\n* Pathological hearing or increased sensitivity to loud noises\n* Claustrophobia\n* Surgery less than three months ago\n* Moderate or severe head injury",true,"FEMALE","8 Years","17 Years",{"count":82,"type":83},100,"ESTIMATED","OBSERVATIONAL","Pubertal transition leads to enduring neuroendocrine changes along with changes in the epigenome. The prevalence of psychiatric disorders significantly increases in females compared to males after puberty. There is likely to be an interaction between epigenetics, hormones and neurophysiological processes during puberty, leading to the increased prevalence of mental disorders in females. This study aims to shed light on these interactions underlying the emerging sex differences after puberty. Specifically, it seeks to investigate the epigenetic modifications and subsequent changes in gene expression during the pubertal transition and their association with negative emotionality (e.g., acute stress response and depressive symptoms) at molecular, neuronal, subjective and physiological levels.",[87,88,21],"Puberty","Healthy",[90,91,92],"Stress reactivity","DNA methylation","fMRI","2024-11-14",{"date":95,"type":96},"2024-11-15","ACTUAL",{"date":98,"type":96},"2024-03-26",{"date":100,"type":83},"2026-04",{"name":5,"class":6},1]