[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100425804":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":36,"locations":45,"responsibleParty":66,"collaborators":26,"id":68,"slug":69,"hasResults":70,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":26,"eligibilityCriteria":74,"healthyVolunteers":70,"sex":75,"minAge":76,"maxAge":77,"enrollmentInfo":78,"targetDuration":26,"studyType":81,"phases":82,"briefSummary":84,"conditions":85,"keywords":87,"overallStatus":89,"whyStopped":26,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":94,"completionDateStruct":95,"leadSponsor":97,"locationsCount":98},{"fullName":5,"class":6},"First Affiliated Hospital Xi'an Jiaotong University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"neoadjuvant PDT + radical surgery","EXPERIMENTAL","Photodynamic therapy for neoadjuvant treatment of cholangiocarcinoma",[13],"Procedure: Neoadjuvant PDT + radical surgery",{"label":15,"type":16,"description":17,"interventionNames":18},"radical surgery","ACTIVE_COMPARATOR","Patients with cholangiocarcinoma undergo radical surgical resection",[19],"Procedure: Radical surgery",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"PROCEDURE","Neoadjuvant PDT + radical surgery","Patients with cholangiocarcinoma will undergo radical surgery after photodynamic therapy",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Radical surgery","Patients with cholangiocarcinoma will only receive radical surgery",[15],[32],{"name":33,"affiliation":34,"role":35},"Yi Lv, MD,PHD","China, Shaanxi First Affiliated Hospital of Xian JiaotongUniversity","PRINCIPAL_INVESTIGATOR",[37,41],{"name":33,"role":38,"phone":39,"phoneExt":26,"email":40},"CONTACT","86-29-85323900","luyi169@126.com",{"name":42,"role":38,"phone":43,"phoneExt":26,"email":44},"Rongfeng Wang, MD","86-29-85324467","15877553630@163.com",[46],{"facility":47,"status":26,"city":48,"state":49,"zip":50,"country":51,"countryCode":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":59},"Yi Lv","Xi'an","Shaanxi","710061","China","CN",{"type":54,"coordinates":55},"Point",[56,57],108.92861,34.25833,{"lat":57,"lon":56},[60,62,65],{"name":33,"role":38,"phone":61,"phoneExt":26,"email":40},"0086-13991200581",{"name":63,"role":38,"phone":64,"phoneExt":26,"email":44},"Xiaogang Zang, MD","0086-15877553630",{"name":33,"role":35,"phone":26,"phoneExt":26,"email":26},{"type":67,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100425804","neoadjuvant-pdt-in-the-treatment-of-cholangiocarcinoma-100425804",false,"NCT04824742","Neoadjuvant PDT in the Treatment of Cholangiocarcinoma","A Prospective Randomized Controlled Study of Neoadjuvant PDT in the Treatment of Cholangiocarcinoma","Inclusion Criteria:\n\n* Patients with age between 18 to 75 years;\n* Patients'gender was not limited;\n* Patients with locally advanced cholangiocarcinoma who have a clear diagnosis of the primary disease and require surgical resection or potential surgical resection;\n* No history of radiotherapy and chemotherapy;\n* Willing to accept this clinical trial, sign informed consent and be able to cooperate with follow-up.\n\nExclusion Criteria:\n\n* Women during pregnancy or breastfeeding, and those with mental illness;\n* Patients allergic to porphyrin drugs, porphyria;\n* Long-term use of glucocorticoids or autoimmune suppression;\n* Surgical contraindication, including:\n\nChild-Pugh C with hepatic encephalopathy Anyone with heart, lung, kidney dysfunction or other organ dysfunction, and cannot tolerate surgery.Hepatic ducts stone disease, who was diagnosed as Acute Cholangitis of Severe Type, especially complicated with bacteremia or septic shock. End stage disease, complicated with biliary cirrhosis or portal hypertension.Patients with long- term obstructive jaundice, dehydration, electrolyte disturbance or coagulation defects; Patients have the tendency or history of bleeding.","ALL","18 Years","75 Years",{"count":79,"type":80},50,"ESTIMATED","INTERVENTIONAL",[83],"NA","For patients with locally advanced cholangiocarcinoma with resectable margins, patients who meet the selection criteria are randomly divided into two groups A and B. Group A: neoadjuvant PDT therapy combined with radical surgery; Group B: radical surgery. This study aims to explore the clinical effectiveness and safety of neoadjuvant photodynamic therapy for cholangiocarcinoma, as well as its role in destroying local tumors and enhancing systemic inflammation.",[86],"Cholangiocarcinoma Resectable",[88],"Cholangiocarcinoma,Neoadjuvant therapy,Photodynamic therapy","NOT_YET_RECRUITING","2021-03-30",{"date":92,"type":93},"2021-04-01","ACTUAL",{"date":92,"type":80},{"date":96,"type":80},"2028-04-01",{"name":5,"class":6},1]