[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100585349":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":30,"locations":39,"responsibleParty":60,"collaborators":63,"id":66,"slug":67,"hasResults":68,"nctId":69,"briefTitle":70,"officialTitle":71,"acronym":18,"eligibilityCriteria":72,"healthyVolunteers":68,"sex":73,"minAge":74,"maxAge":18,"enrollmentInfo":75,"targetDuration":18,"studyType":78,"phases":79,"briefSummary":81,"conditions":82,"keywords":85,"overallStatus":92,"whyStopped":18,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":102},{"fullName":5,"class":6},"Royal Hospital For Women","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"NPLUS","ACTIVE_COMPARATOR","In the NPLUS block, lung ultrasound is performed at T0 (reported persistent increased FiO2 demand) and T1 (one hour after T0). NPLUS may be able to detect loss of aeration and lead to more targeted interventions to improve lung aeration.",[13],"Procedure: Neonatologist performed lung ultrasound",{"label":15,"type":16,"description":17,"interventionNames":18},"Control","NO_INTERVENTION","Routine Care",null,[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":18},"PROCEDURE","Neonatologist performed lung ultrasound","Neonatologist performed lung ultrasound is performed at T0 (reported persistent increased FiO2 demand) and T1 (one hour after T0). NPLUS may be able to detect loss of aeration and lead to more targeted interventions to improve lung aeration. A comprehensive lung ultrasound examination will take 5 minutes or less to perform and involves minimal handling for the patient.",[9],[26],{"name":27,"affiliation":28,"role":29},"Tim Schindler BMedSc MBBS FRACP PhD","Senior Staff Specialist, Royal Hospital for Women, Conjoint Associate Professor, University of New South Wales","PRINCIPAL_INVESTIGATOR",[31,35],{"name":27,"role":32,"phone":33,"phoneExt":18,"email":34},"CONTACT","+61293826190","tim.schindler@health.nsw.gov.au",{"name":36,"role":32,"phone":37,"phoneExt":18,"email":38},"Viktoria Gruber, Dr.med.univ.","+436649703521","vi.gruber@medunigraz.at",[40],{"facility":41,"status":18,"city":42,"state":43,"zip":44,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"Newborn Intensive Care Unit, Royal Hospital for Women","Sydney","New South Wales","2031","Australia","AU",{"type":48,"coordinates":49},"Point",[50,51],151.20732,-33.86785,{"lat":51,"lon":50},[54,56],{"name":27,"role":32,"phone":55,"phoneExt":18,"email":34},"• +61408394008",{"name":57,"role":32,"phone":58,"phoneExt":18,"email":59},"Meredith Ward BMedSc MBBS, FRACP","+61414774914","Meredith.ward@health.nsw.gov.au",{"type":29,"investigatorFullName":61,"investigatorTitle":62,"investigatorAffiliation":5,"oldNameTitle":18,"oldOrganization":18},"Tim Schindler","Senior Staff Specialist, Royal Hospital for Women; Conjoint Associate Professor, University of New South Wales",[64],{"name":65,"class":6},"Medical University of Graz","100585349","neonatologist-performed-lung-ultrasound-nplus-to-guide-respiratory-therapy-100585349",false,"NCT06901206","Neonatologist-Performed Lung Ultrasound (NPLUS) to Guide Respiratory Therapy","Neonatologist-Performed Lung Ultrasound (NPLUS) to Guide Respiratory Therapy on Non-Invasive Ventilation in Preterm Infants","Inclusion Criteria:\n\n* All preterm infants (\\\u003C33 weeks gestational age) from their 2nd week of life, receiving respiratory support via NCPAP\n* expected to stay on NCPAP for the following 5 days at the NICU, Royal Hospital for Women, Randwick, Sydney\n* provided written informed consent obtained from parents.\n\nExclusion Criteria:\n\n* Neonates with previous abdominal surgery\n* Major congenital anomalies.\n* \\>33+0 weeks\n* Less than 1 week of age\n* Invasive ventilation\n* Bilevel or Multilevel non-invasive ventilation\n* Not expected respiratory support via CPAP for the following 5 days.","ALL","1 Week",{"count":76,"type":77},20,"ESTIMATED","INTERVENTIONAL",[80],"NA","The goal of this cross-over clinical trial is to evaluate whether Neonatologist-Performed Lung Ultrasound (NPLUS) can be used in preterm babies on non-invasive breathing support to reduce the amount of oxygen they need. The main question it aims to answer is:\n\nWhen a baby's oxygen requirement goes up, does NPLUS help to target interventions and reduce oxygen requirements?\n\nResearchers will compare NPLUS to standard treatment.\n\nParticipants will:\n\nHave a lung ultrasound performed whenever their oxygen requirement increases by more than 10%.\n\nThe ultrasound findings will be used to target interventions that aim to improve air entry in the lungs.\n\nEach time this happens, the researchers will note what happens to the oxygen requirement afterwards.\n\nEach participant will participate for five days. For the first two days, they will be randomized to either the NPLUS arm or the usual care arm.\n\nThere is then a 24 hour period of usual care. For the final two days, participants cross over to the other arm of the trial.",[83,84],"PreTerm Neonate","Respiratory Distress Syndrome (RDS)",[9,22,86,87,88,89,90,91],"lung ultrasound score","CPAP","loss of aeration","atelectasis","preterm neonate","respiratory distress syndrome","NOT_YET_RECRUITING","2025-03-23",{"date":95,"type":96},"2025-03-28","ACTUAL",{"date":98,"type":77},"2025-03",{"date":100,"type":77},"2026-06",{"name":5,"class":6},1]