[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100552168":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":24,"centralContacts":29,"locations":34,"responsibleParty":61,"collaborators":18,"id":63,"slug":64,"hasResults":65,"nctId":66,"briefTitle":67,"officialTitle":68,"acronym":18,"eligibilityCriteria":69,"healthyVolunteers":65,"sex":70,"minAge":71,"maxAge":72,"enrollmentInfo":73,"targetDuration":18,"studyType":76,"phases":77,"briefSummary":79,"conditions":80,"keywords":82,"overallStatus":37,"whyStopped":18,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":96},{"fullName":5,"class":6},"Medical University of Graz","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"NPLUS group","EXPERIMENTAL","In the NPLUS group (intervention group) lung ultrasound is performed at time point T0 (prior to extubation), T1 (2-4 hours post extubation) and time point T2 (16-24 h) post extubation.",[13],"Other: NPLUS (neonatologist performed lung ultrasound)",{"label":15,"type":16,"description":17,"interventionNames":18},"control group","NO_INTERVENTION","Includes routine care in the control group in case of clinical (respiratory) deterioration which is optional chest x-ray or NPLUS at any time point after extubation indicated by the clinician in charge. There are no study-specific measures in the control group.",null,[20],{"type":6,"name":21,"description":22,"armGroupLabels":23,"otherNames":18},"NPLUS (neonatologist performed lung ultrasound)","NPLUS is conducted with an ultrasound scanner using a high-frequency (12-15 MHz) linear transducer probe (scanning depth approximately 4-5 cm). The neonate is placed in a supine position. The anterior, lateral and posterior chest areas are scanned using the presets \"lung\" or \"small parts\". Landmarks are the anterior and posterior axillary line (longitudinal) on each hemithorax. A sequential scan from right to left, anterior to posterior is performed. (6 lung areas). In the study NPLUS is performed to quantify the lung ultrasound score at time points T0, T1 and T2. Sequences of 3-5 seconds are saved and assessed according to the lung ultrasound score adapted by Rodriguez-Fanjul et al. (0- to 3 point score for each area, resulting in a total score ranging from 0 to 18). To ensure inter-observer reliability the anonymous video sequences are then rated by two independent neonatologists.",[9],[25],{"name":26,"affiliation":27,"role":28},"Bernhard Schwaberger, MD PhD","Division of Neonatology, Medical University of Graz, Austria","PRINCIPAL_INVESTIGATOR",[30],{"name":26,"role":31,"phone":32,"phoneExt":18,"email":33},"CONTACT","+4331638530018","bernhard.schwaberger@medunigraz.at",[35],{"facility":36,"status":37,"city":38,"state":39,"zip":40,"country":41,"countryCode":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":49},"Department of Pediatrics, Division of Neonatology, Medical University of Graz","RECRUITING","Graz","Styria","8036","Austria","AT",{"type":44,"coordinates":45},"Point",[46,47],15.44197,47.06733,{"lat":47,"lon":46},[50,53,56,57,59],{"name":51,"role":31,"phone":18,"phoneExt":18,"email":52},"Viktoria Gruber, MD","vi.gruber@medunigraz.at",{"name":54,"role":31,"phone":55,"phoneExt":18,"email":33},"Bernhard Schwaberger, MD","004331638530018",{"name":26,"role":28,"phone":18,"phoneExt":18,"email":18},{"name":51,"role":58,"phone":18,"phoneExt":18,"email":18},"SUB_INVESTIGATOR",{"name":60,"role":58,"phone":18,"phoneExt":18,"email":18},"Nariae Baik-Schneditz, MD PhD",{"type":62,"investigatorFullName":18,"investigatorTitle":18,"investigatorAffiliation":18,"oldNameTitle":18,"oldOrganization":18},"SPONSOR","100552168","neonatologist-performed-lung-ultrasound-nplus-to-guide-respiratory-therapy-to-prevent-extubation-failure-100552168",false,"NCT06469580","Neonatologist-performed Lung Ultrasound (NPLUS) to Guide Respiratory Therapy to Prevent Extubation Failure","Neonatologist-performed Lung Ultrasound (NPLUS) to Guide Respiratory Therapy to Prevent Extubation Failure in Term and Preterm Neonates- a Randomized Controlled Pilot Trial","Inclusion Criteria:\n\n* All preterm and full-term neonates receiving invasive mechanical ventilation at the Division of Neonatology of the Medical University of Graz AND\n* Written informed consent was obtained from parents prior to extubation\n\nExclusion Criteria:\n\nnone","ALL","1 Minute","6 Months",{"count":74,"type":75},40,"ESTIMATED","INTERVENTIONAL",[78],"NA","The objective of the study is to evaluate the role of neonatologist-performed lung ultrasound (NPLUS) after weaning from invasive mechanical ventilation and extubation. Our aim is to study the diagnostic accuracy of NPLUS and investigate whether LUS leads to earlier actions before clinical deterioration and hence prevents extubation failure.",[81],"Neonatal Disease",[83,84,85,86],"neonatologist performed lung ultrasound","extubation failure","neonates","consolidation","2024-06-17",{"date":89,"type":90},"2024-06-21","ACTUAL",{"date":92,"type":90},"2024-06-01",{"date":94,"type":75},"2025-05",{"name":5,"class":6},1]