[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100488290":3},{"organization":4,"armGroups":7,"interventions":17,"overallOfficials":23,"centralContacts":27,"locations":33,"responsibleParty":104,"collaborators":107,"id":116,"slug":117,"hasResults":118,"nctId":119,"briefTitle":120,"officialTitle":120,"acronym":10,"eligibilityCriteria":121,"healthyVolunteers":118,"sex":122,"minAge":123,"maxAge":124,"enrollmentInfo":125,"targetDuration":128,"studyType":129,"phases":10,"briefSummary":130,"conditions":131,"keywords":140,"overallStatus":36,"whyStopped":10,"lastUpdateSubmitDate":148,"lastUpdatePostDateStruct":149,"startDateStruct":152,"completionDateStruct":154,"leadSponsor":156,"locationsCount":157},{"fullName":5,"class":6},"University of British Columbia","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Experimental: Surgical Arm",null,"Individuals in this group will receive nerve transfer surgery 6 - 9 months post cervical spine injury and be observed for two years post-operatively.",[13],"Procedure: Nerve transfer surgery",{"label":15,"type":10,"description":16,"interventionNames":10},"Control: Non-surgical","Historical control data will be drawn from a published multi-center longitudinal trial that assessed outcomes in individuals with acute traumatic cervical SCI within ten days of injury (baseline), and again at one, three, six, and 12 months post-injury (PMID: 35652348). The general inclusion criteria for this study was traumatic tetraplegia, at least 1\u002F5 strength in the C5 myotome, age 16 years or older, and the ability to provide informed consent. Exclusion criteria included brain injury or other neurological impairments affecting upper limb function. Participants in the surgical cohort will be matched 1:1 with historical controls based on age, sex, and injury characteristics (i.e., NLI and AIS grade).",[18],{"type":19,"name":20,"description":21,"armGroupLabels":22,"otherNames":10},"PROCEDURE","Nerve transfer surgery","The intervention in this study, which follows our clinical approach, is the \"double nerve transfer\" to restore grasp function (i.e., hand opening and hand closing). Finger and thumb extension (hand opening) is restored via the supinator-posterior interosseous nerve (PIN) transfer. Finger and thumb flexion (hand closing) is restored via a nerve transfer to the anterior interosseous nerve (AIN). There are two donor nerve options available to restore function to the muscles supplied by the AIN: the nerve to the brachialis and the nerve to the extensor carpi radialis longus (ECRL) or extensor carpi radialis brevis (ECRB).",[9],[24],{"name":25,"affiliation":5,"role":26},"Michael Berger, MD, PHD","PRINCIPAL_INVESTIGATOR",[28],{"name":29,"role":30,"phone":31,"phoneExt":10,"email":32},"Michael Berger, MD, PhD","CONTACT","778-990-7615","michael.berger@vch.ca",[34,62,77,91],{"facility":35,"status":36,"city":37,"state":38,"zip":39,"country":40,"countryCode":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":48},"GF Strong Rehabilitation Hospital","RECRUITING","Vancouver","British Columbia","V5Z 2G9","Canada","CA",{"type":43,"coordinates":44},"Point",[45,46],-123.11934,49.24966,{"lat":46,"lon":45},[49,52,53,56,58,60],{"name":50,"role":30,"phone":10,"phoneExt":10,"email":51},"Harvey Wu, MD","harvey.wu@ubc.ca",{"name":29,"role":26,"phone":10,"phoneExt":10,"email":10},{"name":54,"role":55,"phone":10,"phoneExt":10,"email":10},"Russell O'Connor, MD","SUB_INVESTIGATOR",{"name":57,"role":55,"phone":10,"phoneExt":10,"email":10},"Erin Brown, MD",{"name":59,"role":55,"phone":10,"phoneExt":10,"email":10},"Chris Doherty, MD",{"name":61,"role":55,"phone":10,"phoneExt":10,"email":10},"Amy Hanlan, MD",{"facility":63,"status":36,"city":64,"state":65,"zip":66,"country":40,"countryCode":41,"cosmosGeoPoint":67,"geoPoint":71,"contacts":72},"QEII Health Sciences Centre","Halifax","Nova Scotia","B3H 3A7",{"type":43,"coordinates":68},[69,70],-63.57688,44.64269,{"lat":70,"lon":69},[73,75],{"name":74,"role":30,"phone":10,"phoneExt":10,"email":10},"Emily Krauss",{"name":76,"role":26,"phone":10,"phoneExt":10,"email":10},"Emily Krauss, MD, MSc",{"facility":78,"status":36,"city":79,"state":80,"zip":81,"country":40,"countryCode":41,"cosmosGeoPoint":82,"geoPoint":86,"contacts":87},"Kingston Health Sciences Centre","Kingston","Ontario","K7L 5G2",{"type":43,"coordinates":83},[84,85],-76.48098,44.22976,{"lat":85,"lon":84},[88,90],{"name":89,"role":30,"phone":10,"phoneExt":10,"email":10},"Michael Hendry, MD, MSc",{"name":89,"role":26,"phone":10,"phoneExt":10,"email":10},{"facility":92,"status":36,"city":93,"state":80,"zip":94,"country":40,"countryCode":41,"cosmosGeoPoint":95,"geoPoint":99,"contacts":100},"Sunnybrook Health Sciences Centre","Toronto","M4N 3M5",{"type":43,"coordinates":96},[97,98],-79.39864,43.70643,{"lat":98,"lon":97},[101,103],{"name":102,"role":30,"phone":10,"phoneExt":10,"email":10},"Jana Dengler, MD, MASc",{"name":102,"role":26,"phone":10,"phoneExt":10,"email":10},{"type":26,"investigatorFullName":105,"investigatorTitle":106,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Michael Berger","Clinical Assistant Professor",[108,110,112,114],{"name":109,"class":6},"Queen's University",{"name":111,"class":6},"Dalhousie University",{"name":113,"class":6},"University of Toronto",{"name":115,"class":6},"Wings for Life","100488290","nerve-transfer-surgery-to-restore-upper-limb-function-after-cervical-spinal-cord-injury-100488290",false,"NCT05638191","Nerve Transfer Surgery to Restore Upper-limb Function After Cervical Spinal Cord Injury","Inclusion Criteria:\n\n* Traumatic, motor-complete cervical SCI (AIS A or B)\n* Male or female, ages 18-70\n* Consent and plan to undergo nerve transfer to restore grasp function in at least one limb\n* Motor grade 4-5 at C5\n* Motor grade 0-1 at C8\u002FT1\n* Injury duration within 6 months at the time of surgery\n* English-speaking and cognitively intact\n* Able to provide informed written consent\n* Able to attend and comply with the testing protocols\n\nExclusion Criteria:\n\n* Inability or unwillingness to participate in post-operative rehabilitation (in person or virtual)\n* Secondary complication of SCI (e.g., intractable neuropathic pain, edema, contracture) or major medical comorbidity (e.g., traumatic brain injury) that would independently influence response to surgery or ability to participate in rehabilitation","ALL","18 Years","70 Years",{"count":126,"type":127},40,"ESTIMATED","2 Years","OBSERVATIONAL","The goal of this prospective, open-label cohort study is to assess functional outcomes in individuals with cervical spinal cord injury who have undergone nerve transfer surgery to restore upper limb function. The main questions it aims to answer are:\n\n* Does nerve transfer improve hand function in individuals with cervical spinal cord injury?\n* What factors are associated with functional improvement following nerve transfer? Researchers will compare functional outcomes at 24 months post-surgery to 1) baseline outcomes and 2) individuals with cervical spinal cord injury who did not undergo nerve transfer.\n\nParticipants who have received nerve transfer surgery as part of their regular medical care will complete functional hand tests, electrodiagnostic assessments, and questionnaires on independence and mood every 3 months for 24 months after surgery.",[132,133,134,135,136,137,138,139],"Spinal Cord Injury","Spinal Cord Injury at C5-C7 Level","SCI - Spinal Cord Injury","Upper Extremity Paralysis","Upper Extremity Dysfunction","Tetraplegia","Upper Extremity Paresis","Cervical Spinal Cord Injury",[141,142,143,144,145,146,147],"spinal cord injury","upper extremity nerve transfer","nerve transfer","SCI","nerve reconstruction","quadriplegia","paresis","2026-05-27",{"date":150,"type":151},"2026-05-29","ACTUAL",{"date":153,"type":151},"2021-06-03",{"date":155,"type":127},"2028-01",{"name":5,"class":6},4]