[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100552346":3},{"organization":4,"armGroups":7,"interventions":23,"overallOfficials":34,"centralContacts":39,"locations":10,"responsibleParty":44,"collaborators":10,"id":48,"slug":49,"hasResults":50,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":56,"sex":57,"minAge":58,"maxAge":59,"enrollmentInfo":60,"targetDuration":10,"studyType":63,"phases":10,"briefSummary":64,"conditions":65,"keywords":10,"overallStatus":67,"whyStopped":10,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":10},{"fullName":5,"class":6},"LanZhou University","OTHER",[8,15,19],{"label":9,"type":10,"description":11,"interventionNames":12},"CD",null,"Crohn's disease",[13,14],"Radiation: Magnetic resonance imaging scanning","Drug: FMT Protocol",{"label":16,"type":10,"description":17,"interventionNames":18},"UC","ulcerative colitis",[13,14],{"label":20,"type":10,"description":21,"interventionNames":22},"HC","healthy controls",[13],[24,29],{"type":25,"name":26,"description":27,"armGroupLabels":28,"otherNames":10},"RADIATION","Magnetic resonance imaging scanning","Perform brain diffusion imaging, magnetic resonance spectroscopy, and functional magnetic resonance imaging scans on all individuals",[9,20,16],{"type":30,"name":31,"description":32,"armGroupLabels":33,"otherNames":10},"DRUG","FMT Protocol","Treatment of disease groups (UC and CD) using prepared fecal microbiota transplantation solution",[9,16],[35],{"name":36,"affiliation":37,"role":38},"Jun Wang, Doctor","The Second Hospital & Clinical Medical School, Lanzhou University","STUDY_CHAIR",[40],{"name":36,"role":41,"phone":42,"phoneExt":10,"email":43},"CONTACT","+8618298366202","wangj20@lzu.edu.cn",{"type":45,"investigatorFullName":46,"investigatorTitle":47,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Jun Wang","Principal Investigator","100552346","neural-circuit-mechanism-of-inflammatory-bowel-disease-combined-with-depression-100552346",false,"NCT06471894","Neural Circuit Mechanism of Inflammatory Bowel Disease Combined With Depression","Study on the Neural Circuit Mechanism of Regulating GABA by Gut Microbiota in Inflammatory Bowel Disease Combined With Depression","NCMOIBDCWD","Inclusion Criteria:\n\naged 18-65 years right-handed active disease (CDAI score ≥150, Mayo score \\>2).\n\nExclusion Criteria:\n\nprevious brain surgery those with severe and unstable physical diseases those with contraindications for MRI who cannot tolerate long-duration MRI examinations.",true,"ALL","18 Years","65 Years",{"count":61,"type":62},100,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to understand the effects of gut microbiota dysbiosis treatment in patients with inflammatory bowel disease (IBD) combined with depression. The main question it aims to answer is:\n\nDoes fecal microbiota transplantation (FMT) improve depression symptoms in IBD patients by altering GABA levels in the medial prefrontal cortex?\n\nParticipants already undergoing fecal microbiota transplantation (FMT) as part of their regular medical care for IBD and comorbid depression will undergo regular assessments of GABA levels, gut microbiota, and depression symptoms for the duration of the study.",[66],"Inflammatory Bowel Diseases","NOT_YET_RECRUITING","2024-06-23",{"date":70,"type":71},"2024-06-25","ACTUAL",{"date":73,"type":62},"2024-07-01",{"date":75,"type":62},"2027-12-01",{"name":5,"class":6}]